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Structural basis of cytokine-mediated activation of ALK family receptors

mercredi 13 octobre 2021 par Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J. Fernando Bazan, Akihide Yoshimi, Savvas N. Savvides
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03959-5Structural studies of the complex of anaplastic lymphoma kinase and leukocyte tyrosine kinase and their activating cytokines identify unique architectural features of the complex, and provide a novel mechanistic paradigm (...)

The cellular environment shapes the nuclear pore complex architecture

mercredi 13 octobre 2021 par Anthony P. Schuller, Matthias Wojtynek, David Mankus, Meltem Tatli, Rafael Kronenberg-Tenga, Saroj G. Regmi, Phat V. Dip, Abigail K. R. Lytton-Jean, Edward J. Brignole, Mary Dasso, Karsten Weis, Ohad Medalia, Thomas U. Schwartz
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03985-3Structure of human nuclear pore complex in its cellular environment reveals a substantially dilated central channel and shows that its nucleoplasmic and cytoplasmic rings restrict channel dimensions and create membrane (...)

A two-step hormone-signalling mechanism that drives physical activity

mercredi 13 octobre 2021 par Stephanie L. Padilla
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02725-xIn mice, the ovarian hormone oestradiol sensitizes neurons in a brain region called the hypothalamus to a melanocortin hormone that signals an energy surplus. Their dual activation increases physical (...)

Venus might never have been habitable

mercredi 13 octobre 2021 par James F. Kasting, Chester E. Harman
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02720-2A sophisticated climate model suggests that liquid-water oceans never formed on Venus, and that some planets outside the Solar System that were thought to be habitable might not (...)

‘I hope you die’: how the COVID pandemic unleashed attacks on scientists

mercredi 13 octobre 2021 par Bianca Nogrady
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02741-xDozens of researchers tell Nature they have received death threats, or threats of physical or sexual violence.

Leprosy in wild chimpanzees

mercredi 13 octobre 2021 par Kimberley J. Hockings, Benjamin Mubemba, Charlotte Avanzi, Kamilla Pleh, Ariane Düx, Elena Bersacola, Joana Bessa, Marina Ramon, Sonja Metzger, Livia V. Patrono, Jenny E. Jaffe, Andrej Benjak, Camille Bonneaud, Philippe Busso, Emmanuel Couacy-Hymann, Moussa Gado, Sebastien Gagneux, Roch C. Johnson, Mamoudou Kodio, Joshua Lynton-Jenkins, Irina Morozova, Kerstin Mätz-Rensing, Aissa Regalla, Abílio R. Said, Verena J. Schuenemann, Samba O. Sow, John S. Spencer, Markus Ulrich, Hyacinthe Zoubi, Stewart T. Cole, Roman M. Wittig, Sebastien Calvignac-Spencer, Fabian H. Leendertz
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03968-4Monitoring of western chimpanzee populations in Guinea-Bissau and Côte d’Ivoire reveals the presence of rare and different genotypes of Mycobacterium leprae, suggesting greater circulation in wild animals than previously (...)

Vaccines and Delta, Moon volcanism and an NIH departure

mercredi 13 octobre 2021
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02759-1The latest science news, in brief.

Nobel-winning ‘natural experiments’ approach made economics more robust

mercredi 13 octobre 2021 par Philip Ball
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02799-7Joshua Angrist, Guido Imbens and David Card share the prize for finding a way to identify cause and effect in social science.

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis

mercredi 13 octobre 2021 par Shenbin Liu, Zhifu Wang, Yangshuai Su, Lu Qi, Wei Yang, Mingzhou Fu, Xianghong Jing, Yanqing Wang, Qiufu Ma
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-04001-4Neuroanatomical findings demonstrate why electroactupuncture at only specific acupoints can drive the vagal–adrenal axis and treat inflammation in mice.

Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3

mercredi 13 octobre 2021 par Bingting Ma, Cuiqing Huang, Jun Ma, Ye Xiang, Xinzheng Zhang
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03909-1The cryo-electron microscopy structure of domain 1 of the LDLRAD3 receptor in complex with virus-like particles of Venezuelan equine encephalitis virus (VEEV) provides insights into the assembly and entry of VEEV and other (...)

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