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Mechanical release of homogenous proteins from supramolecular gels

mardi 16 juillet 2024 par Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07580-0A stiff hydrogel gel is presented that encapsulates and stabilizes proteins without additives or excipients and uses mechanical strain to release them, offering low-cost and versatile delivery of (...)

Nature

Clonal inactivation of TERT impairs stem cell competition

mardi 16 juillet 2024 par Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces, Patrick Neuhöfer, Victoria M. Gillespie, Peggie Cheung, Julia A. Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y. Chang, Steven E. Artandi

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07700-wStudies in mice show that telomerase reverse transcriptase (TERT) has a role in enhancing stem cell competition that is independent of its reverse transcriptase activity, and promotes chromatin accessibility and activity of (...)

Nature

Sources of gene expression variation in a globally diverse human cohort

mardi 16 juillet 2024 par Dylan J. Taylor, Surya B. Chhetri, Michael G. Tassia, Arjun Biddanda, Stephanie M. Yan, Genevieve L. Wojcik, Alexis Battle, Rajiv C. McCoy

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07708-2A new open-access RNA sequencing dataset, MAGE, of 731 individuals across geographically diverse human populations provides a valuable resource to study genetic diversity and evolution and expands the capacity to identify new (...)

Nature

Sunlight-powered sustained flight of an ultralight micro aerial vehicle

mardi 16 juillet 2024 par Wei Shen, Jinzhe Peng, Rui Ma, Jiaqing Wu, Jingyi Li, Zhiwei Liu, Jiaming Leng, Xiaojun Yan, Mingjing Qi

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07609-4Solar-powered, untethered, sustained flight of an ultralight micro aerial vehicle under natural sunlight conditions is achieved using an electrostatic-driven propulsion system with a high lift-to-power (...)

Nature

Tubulin code eraser CCP5 binds branch glutamates by substrate deformation

mardi 16 juillet 2024 par Jiayi Chen, Elena A. Zehr, James M. Gruschus, Agnieszka Szyk, Yanjie Liu, Martin E. Tanner, Nico Tjandra, Antonina Roll-Mecak

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07699-0Cryo-electron microscopy and X-ray structures of the glutamylation eraser CCP5 in complexes with glutamylated microtubules and tubulin tails show that the substrate backbone adopts a bent conformation that presents the branch (...)

Nature

Psilocybin desynchronizes the human brain

mardi 16 juillet 2024 par Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay, Evan M. Gordon, Timothy O. Laumann, T. Rick Reneau, Nicholas V. Metcalf, Ravi V. Chacko, Caterina Gratton, Christine Horan, Samuel R. Krimmel, Joshua S. Shimony, Julie A. Schweiger, Dean F. Wong, David A. Bender, Kristen M. Scheidter, Forrest I. Whiting, Jonah A. Padawer-Curry, Russell T. Shinohara, Yong Chen, Julia Moser, Essa Yacoub, Steven M. Nelson, Luca Vizioli, Damien A. Fair, Eric J. Lenze, Robin Carhart-Harris, Charles L. Raison, Marcus E. Raichle, Abraham Z. Snyder, Ginger E. Nicol, Nico U. F. Dosenbach

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07624-5Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disrupt functional (...)

Nature

A eukaryotic-like ubiquitination system in bacterial antiviral defence

mardi 16 juillet 2024 par Lydia R. Chambers, Qiaozhen Ye, Jiaxi Cai, Minheng Gong, Hannah E. Ledvina, Huilin Zhou, Aaron T. Whiteley, Raymond T. Suhandynata, Kevin D. Corbett

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07730-4A study reports the structure and molecular mechanism of the Bil anti-phage defence system, demonstrating that it is the closest prokaryotic homologue of canonical eukaryotic ubiquitination (...)

Nature

Identification of plant transcriptional activation domains

mardi 16 juillet 2024 par Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J. Emenecker, John A. Bryant Jr., Tyler M. Lee, Katelyn Sageman-Furnas, Edward G. Wilkinson, Sunita Pathak, Sanjana R. Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R. Clay Wright, Alex S. Holehouse, Max V. Staller, Rosangela Sozzani, Lucia C. Strader

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07707-3A high-throughput yeast-based assay is used to identify more than 1,500 activation domains (ADs) in Arabidopsis transcription factors, and a deep learning approach applied to this dataset can predict AD activity on the basis (...)

Nature

Position-dependent function of human sequence-specific transcription factors

mardi 16 juillet 2024 par Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz, Christopher Benner

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07662-zThe effect of transcription factor binding on transcription initiation is dependent on the position of the transcription factor binding site.

Nature

An engineered enzyme embedded into PLA to make self-biodegradable plastic

mardi 16 juillet 2024 par M. Guicherd, M. Ben Khaled, M. Guéroult, J. Nomme, M. Dalibey, F. Grimaud, P. Alvarez, E. Kamionka, S. Gavalda, M. Noël, M. Vuillemin, E. Amillastre, D. Labourdette, G. Cioci, V. Tournier, V. Kitpreechavanich, P. Dubois, I. André, S. Duquesne, A. Marty

Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07709-1Embedding of a new engineered thermostable hydrolase into polymer materials enables the production of biodegradable and home-compostable plastics suitable for industrial packaging (...)

Nature