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Identification of broadly tumour-reactive ?? TCRs from multiple myeloma

mercredi 16 septembre 2026 par Michael St. Paul, Liam D. Hendrikse, Fan Ying, Bryan E. Snow, Ping Luo, Simone Helke, Logan K. Smith, Arwa Hilal, Dor D. Abelman, Nisha Ramamurthy, Hayley Nault, Ellen N. Wei, Matthew J. Gold, Chantal Tobin, Scott C. Lien, Yi Liu, Wenjing Zhou, Xin Zhang, Dat Nguyen, Oluwatobi Agbede, Stephanie Pedersen, Jenna Eagles, Mary E. Saunders, Thorsten Berger, Andrew Wakeham, David S. Scott, Dalam Ly, Cecilia Bonolo de Campos, Guanghao Liang, Chunxing Zheng, Wesley V. Wilson, Esther Masih-Khan, Darrell White, Arleigh McCurdy, Martha L. Louzada, Rami Kotb, Michael P. Chu, Stephen Parkin, Donna Reece, Engin Gul, Rodger Tiedemann, Trevor J. Pugh, Naoto Hirano, Pamela S. Ohashi, A. Keith Stewart, Suzanne Trudel, Tak W. Mak

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11055-9A machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion of this cell population can be used as a biomarker of therapeutic (...)

Nature

Cohesin reshapes replication fork contacts to aid fork slowing and reversal

mercredi 16 septembre 2026 par Daniel González-Acosta, Daniel Giménez-Llorente, Melani Rodrigues, Moses Aouami, Orhi Barroso-Gomila, Javier Muñoz, Ana Cuadrado, Ana Losada, Massimo Lopes

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome (...)

Nature

Daily briefing: Reading for pleasure linked to big brain benefits

mardi 15 septembre 2026 par Flora Graham

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02924-4Evidence that reading for fun is related to structural brain changes, improved mental health and reduced risk of cognitive decline. Plus, go prospecting for clean-burning hydrogen gas underground and discover the oldest (...)

Nature

‘Stomach bugs’ send protective immune cells rushing from gut to brain

mardi 15 septembre 2026 par Gemma Conroy

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02891-wVoyaging gut-derived immune cells ‘remember’ past stomach infections in mice.

Nature

Underground hydrogen could spur a green-energy revolution — if companies can find it

mardi 15 septembre 2026 par James Mitchell Crow

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02850-5Firms are racing to drill for hydrogen in hopes of finding a dirt-cheap green-energy source.

Nature

Cities and countryside are intimately linked — green initiatives must recognize that

mardi 15 septembre 2026 par Yansui Liu, Xinxin Huang

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02853-2Urban areas depend on resources from the land that surrounds them. Managing regions in their entirety is the best way to avoid rural decline.

Nature

A wake-up call: diversify global research funding

mardi 15 septembre 2026 par Huixue Zhang, Shiyu Wang

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02904-8A wake-up call: diversify global research funding

Nature

Why Nepal floods resulted in a disaster even after satellites spotted danger

mardi 15 septembre 2026 par Rajeev Bhattarai

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02907-5Why Nepal floods resulted in a disaster even after satellites spotted danger

Nature

The geometric genius of René Descartes

mardi 15 septembre 2026

Nature, Published online: 15 September 2026; doi:10.1038/d41586-026-02723-xThe achievements of a visionary mathematician, and a trip to the National Air and Space Museum in Washington DC, in this week’s pick from the Nature archive.

Nature