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ABCA7 variants impact phosphatidylcholine and mitochondria in neurons

mercredi 10 septembre 2025 par Djuna von Maydell, Shannon E. Wright, Ping-Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, Guillaume Leclerc, Gloria Suella Menchaca, Gwyneth Welch, Agnese Graziosi, Noelle Leary, George Samaan, Manolis Kellis, Li-Huei Tsai

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09520-yLoss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human (...)

Nature

Fluctuating DNA methylation tracks cancer evolution at clinical scale

mercredi 10 septembre 2025 par Calum Gabbutt, Martí Duran-Ferrer, Heather E. Grant, Diego Mallo, Ferran Nadeu, Jacob Househam, Neus Villamor, Madlen Müller, Simon Heath, Emanuele Raineri, Olga Krali, Jessica Nordlund, Thorsten Zenz, Ivo G. Gut, Elias Campo, Armando Lopez-Guillermo, Jude Fitzgibbon, Chris P. Barnes, Darryl Shibata, José I. Martin-Subero, Trevor A. Graham

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09374-4Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Nature

Stabilizing effect of amino acids on protein and colloidal dispersions

mercredi 10 septembre 2025 par Ting Mao, Xufeng Xu, Pamina M. Winkler, Cécilia Siri, Ekaterina Poliukhina, Paulo Jacob Silva, Nan Xu, Yu Hu, Karim Al Zahabi, Rémi La Polla, Zhi Luo, Quy Ong, Alfredo Alexander-Katz, Francesco Stellacci

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09506-wAmino acids possess a new and broad colloidal property: they stabilize patchy nanoscale colloids, such as proteins, by adsorbing onto their surfaces through weak (...)

Nature

Programmable antisense oligomers for phage functional genomics

mercredi 10 septembre 2025 par Milan Gerovac, Leandro Buhlmann, Yan Zhu, Svetlana Ðurica-Miti?, Valentin Rech, Samuel Carien, Tom Gräfenhan, Linda Popella, Jörg Vogel

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09499-6Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagation of the (...)

Nature

The emergence of globular clusters and globular-cluster-like dwarfs

mercredi 10 septembre 2025 par Ethan D. Taylor, Justin I. Read, Matthew D. A. Orkney, Stacy Y. Kim, Andrew Pontzen, Oscar Agertz, Martin P. Rey, Eric P. Andersson, Michelle L. M. Collins, Robert M. Yates

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09494-xThe results from a state-of-the-art suite of hydrodynamical cosmological zoom-in simulations show how globular clusters naturally emerge in the Standard Cosmology and also reveal the existence of a new class of object (...)

Nature

Human gastroids to model regional patterning in early stomach development

mercredi 10 septembre 2025 par Xia Li, Feng Lin, Qiqi Cui, Shiyu Sun, Shixin Li, Yue Wang, Yiting Wang, Jianbo Bai, Shiyi Liu, Jia Guo, Yizhao Han, Meiru Zhang, Tie Chang, Yifan Zheng, Jianlin Liu, Longqi Liu, Leyun Wang, Jianping Fu, Xin Liu, Bing Bai, Yue Shao

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09508-8Neural tissue is a key signalling centre for fundic–antral patterning in development of gastric organoids featuring asymmetric PDX1 patterning.

Nature

The oldest known lepidosaur and origins of lepidosaur feeding adaptations

mercredi 10 septembre 2025 par Daniel Marke, David I. Whiteside, Thitiwoot Sethapanichsakul, Robert A. Coram, Vincent Fernandez, Alexander Liptak, Elis Newham, Michael J. Benton

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09496-9A rhynchocephalian skeleton around 3–7 million years older than the oldest currently known lepidosaur fossil provides important insight into the origin of lizards and (...)

Nature

Long-range PM_2.5 pollution and health impacts from the 2023 Canadian wildfires

mercredi 10 septembre 2025 par Qiang Zhang, Yuexuanzi Wang, Qingyang Xiao, Guannan Geng, Steven J. Davis, Xiaodong Liu, Jin Yang, Jiajun Liu, Wenyu Huang, Changpei He, Binhe Luo, Randall V. Martin, Michael Brauer, James T. Randerson, Kebin He

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09482-1A modelling study based on satellite observations, machine learning and a chemical transport model quantifies the global and regional exposure to particulate-matter pollution and the human health impacts related to the (...)

Nature

Jelly-filled garment keeps wearers cool when heat and humidity soar

mercredi 10 septembre 2025

Nature, Published online: 10 September 2025; doi:10.1038/d41586-025-02875-2Lightweight, battery-powered shirt could maintain skin at a comfortable temperature for hours.

Nature

Feeling the heat: fossil-fuel producers linked to dozens of heatwaves

mercredi 10 septembre 2025 par Benjamin Thompson, Shamini Bundell

Nature, Published online: 10 September 2025; doi:10.1038/d41586-025-02938-4Attribution study suggests major energy producers play an outsized role in causing extreme heatwaves — plus, the scientists fighting back against US funding (...)

Nature