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Multi-omic profiling reveals age-related immune dynamics in healthy adults

mercredi 29 octobre 2025 par Qiuyu Gong, Mehul Sharma, Marla C. Glass, Emma L. Kuan, Aishwarya Chander, Mansi Singh, Lucas T. Graybuck, Zachary J. Thomson, Christian M. LaFrance, Samir Rachid Zaim, Tao Peng, Lauren Y. Okada, Palak C. Genge, Katherine E. Henderson, Elisabeth M. Dornisch, Erik D. Layton, Peter J. Wittig, Alexander T. Heubeck, Nelson M. Mukuka, Julian Reading, Garrett Strawn, Teminijesu Titus-Adewunmi, Kathleen Abadie, Charles R. Roll, Veronica Hernandez, Vaishnavi Parthasarathy, Tyanna J. Stuckey, Blessing Musgrove, Elliott Swanson, Cara Lord, Morgan D. A. Weiss, Cole G. Phalen, Regina R. Mettey, Kevin J. Lee, John B. Johanneson, Erin K. Kawelo, Jessica Garber, Upaasana Krishnan, Megan Smithmyer, E. John Wherry, Laura A. Vella, Sarah E. Henrickson, Mackenzie S. Kopp, Adam K. Savage, Lynne A. Becker, Paul Meijer, Ernest M. Coffey, Jorg J. Goronzy, Mikael Sigvardsson, Cate Speake, Thomas F. Bumol, Ananda W. Goldrath, Troy R. Torgerson, Xiao-jun Li, Peter J. Skene, Jane H. Buckner, Claire E. Gustafson

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09686-5This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to (...)

Nature

Origins of chromosome instability unveiled by coupled imaging and genomics

mercredi 29 octobre 2025 par Marco Raffaele Cosenza, Alice Gaiatto, Bü?ra Erarslan Uysal, Álvaro Andrades, Nina Luisa Sautter, Marina Simunovic, Michael Adrian Jendrusch, Sonia Zumalave, Tobias Rausch, Aliaksandr Halavatyi, Eva-Maria Geissen, Joshua Lucas Eigenmann, Thomas Weber, Patrick Hasenfeld, Eva Benito, Catherine Stober, Isidro Cortes-Ciriano, Andreas E. Kulozik, Rainer Pepperkok, Jan O. Korbel

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09632-5Coupling live-cell imaging, machine learning and genomic sequencing, the MAGIC platform enables investigation of the cellular context, mutation rates and triggers of spontaneous chromosomal abnormality formation, shedding (...)

Nature

Technological pathways for cost-effective steel decarbonization

mercredi 29 octobre 2025 par Xinyi Wu, Jing Meng, Xi Liang, Laixiang Sun, D’Maris Coffman, Andreas Kontoleon, Dabo Guan

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09658-9A model has been developed to identify the least-cost technology pathway for global individual iron and steel plants over 2020–2050 in alignment with national carbon-neutrality (...)

Nature

Magnetotelluric evidence for a melt-rich magmatic reservoir beneath Mayotte

mercredi 29 octobre 2025 par Pierre Wawrzyniak, Fabrice Gaillard, Sophie Hautot, Juan Andujar, Pascal Tarits, Laurent Arbaret, Samuel Guegan, David Sifré, Jean-François D’Eu, Jacques Deparis, Anne Lemoine, Isabelle Thinon, Sheldon Warden, Frédéric Dubois

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09625-4Magnetotelluric data provide evidence of a large melt-rich magmatic reservoir beneath Mayotte island that might be connected to the system that fed the large submarine eruption of Fani Maoré in (...)

Nature

Multiple LDLR family members act as entry receptors for yellow fever virus

mercredi 29 octobre 2025 par Zhenlu Chong, Sean Hui, Xueer Qiu, Sathvik Palakurty, Alan Sariol, Tomasz Kaszuba, Michael N. Nguyen, Pengfei Li, Saravanan Raju, Paige D. Hall, Christopher A. Nelson, Israel Baltazar-Perez, David A. Price, Paul W. Rothlauf, James E. Crowe, Sean P. J. Whelan, Daisy W. Leung, Gaya K. Amarasinghe, Adam L. Bailey, Daved H. Fremont, Michael S. Diamond

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09689-2The low-density lipoprotein receptor family members LRP1, LRP4 and VLDLR are entry receptors for yellow fever virus.

Nature

Energy flows reveal declining ecosystem functions by animals across Africa

mercredi 29 octobre 2025 par Ty Loft, Imma Oliveras Menor, Nicola Stevens, Robert Beyer, Hayley S. Clements, Luca Santini, Seth Thomas, Joseph A. Tobias, Yadvinder Malhi

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09660-1An ecosystem energetics approach, quantifying trophic energy flows across species, offers a unified framework for linking animal biodiversity loss to changes in ecosystem function and Earth system (...)

Nature

Mechanism of conductance control and neurosteroid binding in NMDA receptors

mercredi 29 octobre 2025 par Hyunook Kang, Ruben Steigerwald, Elijah Z. Ullman, Max Epstein, Srinu Paladugu, Dennis C. Liotta, Stephen F. Traynelis, Hiro Furukawa

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09695-4Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate (...)

Nature

Ultrasound-driven programmable artificial muscles

mercredi 29 octobre 2025 par Zhan Shi, Zhiyuan Zhang, Justus Schnermann, Stephan C. F. Neuhauss, Nitesh Nama, Raphael Wittkowski, Daniel Ahmed

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09650-3A soft artificial muscle with programmable actuation is achieved using microbubble arrays and targeted ultrasound activation, with potential applications in soft robotics, wearable technologies, haptics and biomedical (...)

Nature

Sensory expectations shape neural population dynamics in motor circuits

mercredi 29 octobre 2025 par Jonathan A. Michaels, Mehrdad Kashefi, Jack Zheng, Olivier Codol, Jeffrey Weiler, Rhonda Kersten, Jonathan C. Lau, Paul L. Gribble, Jörn Diedrichsen, J. Andrew Pruszynski

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09690-9Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the efficiency of movement (...)

Nature

Helicase-mediated mechanism of SSU processome maturation and disassembly

mercredi 29 octobre 2025 par Olga Buzovetsky, Sebastian Klinge

Nature, Published online: 29 October 2025; doi:10.1038/s41586-025-09688-3Structural studies of 16 native yeast ribosomal small subunit processome structures provide insights into the mechanisms governing the transformation into a pre-40S (...)

Nature