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3D-printed micro ion trap technology for quantum information applications

mercredi 3 septembre 2025 par Shuqi Xu, Xiaoxing Xia, Qian Yu, Abhinav Parakh, Sumanta Khan, Eli Megidish, Bingran You, Boerge Hemmerling, Andrew Jayich, Kristin Beck, Juergen Biener, Hartmut Häffner
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09474-1High-resolution 3D printing technology making use of two-photon polymerization instead of traditional machining is described, allowing low-cost and scalable production of large arrays of high-quality 3D Paul (...)

Adaptive and context-aware volumetric printing

mercredi 3 septembre 2025 par Sammy Florczak, Gabriel Größbacher, Davide Ribezzi, Alessia Longoni, Marième Gueye, Estée Grandidier, Jos Malda, Riccardo Levato
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09436-7A new approach combining 3D imaging, computer vision and parametric modelling, named GRACE, is introduced, enabling adaptive and context-aware 3D printing of structures around features ranging from cellular to (...)

Training of physical neural networks

mercredi 3 septembre 2025 par Ali Momeni, Babak Rahmani, Benjamin Scellier, Logan G. Wright, Peter L. McMahon, Clara C. Wanjura, Yuhang Li, Anas Skalli, Natalia G. Berloff, Tatsuhiro Onodera, Ilker Oguz, Francesco Morichetti, Philipp del Hougne, Manuel Le Gallo, Abu Sebastian, Azalia Mirhoseini, Cheng Zhang, Danijela Markovi?, Daniel Brunner, Christophe Moser, Sylvain Gigan, Florian Marquardt, Aydogan Ozcan, Julie Grollier, Andrea J. Liu, Demetri Psaltis, Andrea Alù, Romain Fleury
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09384-2Methods to train physical neural networks, such as backpropagation-based and backpropagation-free approaches, are explored to allow scaling up of artificial intelligence models far beyond present small-scale laboratory (...)

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2

mercredi 3 septembre 2025 par Benjamin Vollmer, Henriette Ebel, Renate Rees, Julia Nentwig, Thomas Mulvaney, Jürgen Schünemann, Jens Krull, Maya Topf, Dirk Görlich, Kay Grünewald
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09438-5A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and an attractive avenue (...)

Patterned invagination prevents mechanical instability during gastrulation

mercredi 3 septembre 2025 par Bruno C. Vellutini, Marina B. Cuenca, Abhijeet Krishna, Alicja Sza?apak, Carl D. Modes, Pavel Tomancak
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09480-3In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphogenetic innovations in (...)

Brain-wide representations of prior information in mouse decision-making

mercredi 3 septembre 2025 par Charles Findling, Felix Hubert, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, E. Kelly Buchanan, Sebastian Bruijns, Matteo Carandini, Joana A. Catarino, Gaelle A. Chapuis, Anne K. Churchland, Yang Dan, Felicia Davatolhagh, Eric E. J. DeWitt, Tatiana A. Engel, Michele Fabbri, Mayo A. Faulkner, Ila Rani Fiete, Laura Freitas-Silva, Berk Gerçek, Kenneth D. Harris, Michael Häusser, Sonja B. Hofer, Fei Hu, Julia M. Huntenburg, Anup Khanal, Chris Krasniak, Christopher Langdon, Christopher A. Langfield, Peter E. Latham, Petrina Y. P. Lau, Zach Mainen, Guido T. Meijer, Nathaniel J. Miska, Thomas D. Mrsic-Flogel, Jean-Paul Noel, Kai Nylund, Alejandro Pan-Vazquez, Liam Paninski, Jonathan Pillow, Cyrille Rossant, Noam Roth, Rylan Schaeffer, Michael Schartner, Yanliang Shi, Karolina Z. Socha, Nicholas A. Steinmetz, Karel Svoboda, Charline Tessereau, Anne E. Urai, Miles J. Wells, Steven Jon West, Matthew R. Whiteway, Olivier Winter, Ilana B. Witten, Anthony Zador, Yizi Zhang, Peter Dayan, Alexandre Pouget
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09226-1Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Spatial joint profiling of DNA methylome and transcriptome in tissues

mercredi 3 septembre 2025 par Chin Nien Lee, Hongxiang Fu, Angelysia Cardilla, Wanding Zhou, Yanxiang Deng
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09478-xDNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription interact to shape cell identity and (...)

A circuit that integrates drive state and social contact to gate mating

mercredi 3 septembre 2025 par Lindsey D. Salay, Doris Y. Tsao, David J. Anderson
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09327-xAnalyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive (...)

Single-cell transcriptomic and genomic changes in the ageing human brain

mercredi 3 septembre 2025 par Ailsa M. Jeffries, Tianxiong Yu, Jennifer S. Ziegenfuss, Allie K. Tolles, Christina E. Baer, Cesar Bautista Sotelo, Yerin Kim, Zhiping Weng, Michael A. Lodato
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09435-8Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the (...)

Divergent evolutionary strategies pre-empt tissue collision in gastrulation

mercredi 3 septembre 2025 par Bipasha Dey, Verena Kaul, Girish Kale, Maily Scorcelletti, Michiko Takeda, Yu-Chiun Wang, Steffen Lemke
Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09447-4Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit (...)

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