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Amygdala–liver signalling orchestrates glycaemic responses to stress

mercredi 3 septembre 2025 par J. R. E. Carty, K. Devarakonda, R. M. O’Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R. F. Hampton, R. Li, Y. Qiu, S. Petri, A. Shtekler, A. Rajbhandari, K. Conner, M. Bayne, D. Garibay, J. Martin, V. Lehmann, L. Wang, K. Beaumont, I. Kurland, G. C. Yuan, P. J. Kenny, S. A. Stanley

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09420-1Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independently of adrenal and (...)

Nature

DNA2 enables growth by restricting recombination-restarted replication

mercredi 3 septembre 2025 par Jessica J. R. Hudson, Rowin Appanah, David Jones, Kathryn Davidson, Alice M. Budden, Alina Vaitsiankova, Kok-Lung Chan, Keith W. Caldecott, Antony M. Carr, Ulrich Rass

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09470-5DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, highlighting its (...)

Nature

Latent resistance mechanisms of steel truss bridges after critical failures

mercredi 3 septembre 2025 par Juan C. Reyes-Suárez, Manuel Buitrago, Brais Barros, Safae Mammeri, Nirvan Makoond, Carlos Lázaro, Belén Riveiro, Jose M. Adam

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09300-8Experimental tests and computational simulations of a scaled-down specimen of a real steel truss bridge identify and characterize the latent resistance mechanisms following critical failures, demonstrating how loads (...)

Nature

'How is this possible?' — two species birthed by one mother

mercredi 3 septembre 2025 par Nick Petri? Howe

Nature, Published online: 03 September 2025; doi:10.1038/d41586-025-02834-xTwo brother ants defy species borders, by sharing the same mother despite being genetically different species.

Nature

Tiny flier could soar through the mesosphere powered only by light

mercredi 3 septembre 2025 par Dan Fox

Nature, Published online: 03 September 2025; doi:10.1038/d41586-025-02676-7A quirk of physics lets light power flight in low pressure environments.

Nature

Two ants, two species, one mother

mercredi 3 septembre 2025 par Benjamin Thompson, Elizabeth Gibney

Nature, Published online: 03 September 2025; doi:10.1038/d41586-025-02835-wIberian harvester ants can produce males that are genetically different species — plus, new insights into preventing deadly bridge collapses.

Nature

Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition

mercredi 3 septembre 2025 par Xufei Zhou, Rucheng Diao, Xin Li, Christine A. Ziegler, Max J. Gramelspacher, Lydia Freddolino, Zhonggang Hou, Yan Zhang

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09577-9Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition

Nature

Commensal yeast promotes Salmonella Typhimurium virulence

mercredi 3 septembre 2025 par Kanchan Jaswal, Olivia A. Todd, Roberto C. Flores Audelo, William Santus, Saikat Paul, Ciera M. Duffy, Edward T. Eshoo III, Manmeet Singh, Jian Miao, David M. Underhill, Brian M. Peters, Judith Behnsen

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09415-yCommensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

Nature

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

mercredi 3 septembre 2025 par Alena Kozlova, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Stanislau Smirnou, Seul Kee Byeon, Christina Thapa, Xiaotong Sun, Kimberley Stephenson, Xiaojie Zhao, Brendan Jamison, Moorthi Ponnusamy, Xin He, Julie A. Schneider, Akhilesh Pandey, David A. Bennett, Zhiping P. Pang, Alan R. Sanders, Hugo J. Bellen, Gopal Thinakaran, Jubao Duan

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09486-xA PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

Nature

Supervised learning in DNA neural networks

mercredi 3 septembre 2025 par Kevin M. Cherry, Lulu Qian

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09479-wDNA molecules can be programmed to autonomously carry out supervised learning in vitro, with the system learning to perform pattern classification from molecular examples of inputs and desired (...)

Nature