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SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

mercredi 12 novembre 2025 par Hyunjin Noh, Zeena Hashem, Elena Boms, Ayaz Najafov

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09741-1CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a therapeutic (...)

Nature

How much protein do you really need? What the science says

mercredi 12 novembre 2025 par Mariana Lenharo

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03632-1Fitness influencers promote super-high-protein diets, but studies show there’s only so much the body can use.

Nature

GREGoR: accelerating genomics for rare diseases

mercredi 12 novembre 2025 par Moez Dawood, Ben Heavner, Marsha M. Wheeler, Rachel A. Ungar, Jonathan LoTempio, Laurens Wiel, Seth Berger, Jonathan A. Bernstein, Jessica X. Chong, Emmanuèle C. Délot, Evan E. Eichler, James R. Lupski, Ali Shojaie, Michael E. Talkowski, Alex H. Wagner, Chia-Lin Wei, Christopher Wellington, Matthew T. Wheeler, Aashish Adhikari, Kinga M. Bujakowska, Ali Crawford, Aimée Dudley, Kelly D. Farwell Hagman, Yang I. Li, Jill E. Moore, Aaron R. Quinlan, Bo Xia, S. Stephen Yi, Claudia M. B. Carvalho, Richard A. Gibbs, Casey A. Gifford, Susanne May, Danny E. Miller, Heidi L. Rehm, Kaitlin E. Samocha, Fritz J. Sedlazeck, Eric Vilain, Anne O’Donnell-Luria, Jennifer E. Posey, Lisa H. Chadwick, Michael J. Bamshad, Stephen B. Montgomery, Hatoon Al Ali, Elizabeth G. Atkinson, Sairam Behera, Shaghayegh T. Beheshti, Eric Boerwinkle, Tugce Bozkurt-Yozgatli, Daniel G. Calame, Ivan Chinn, Zeynep H. Coban-Akdemir, Karen J. Coveler, Zain Dardas, Harsha Doddapaneni, Haowei Du, Ruizhi Duan, Iman Egab, Jawid Fatih, Mira Gandhi, Brandon Garcia, Nikhita Gogate, Christopher M. Grochowski, Jianhong Hu, Minal Jamsandekar, Shalini N. Jhangiani, Angad Jolly, Parneet Kaur, Ahmed K. Saad, Jesse M. Levine, Richard A. Lewis, Yidan Li, Pengfei Liu, Medhat Mahmoud, Dana Marafi, Tadahiro Mitani, Chloe Munderloh, Donna Muzny, Sebastian Ochoa, Piyush Panchal, Shruti Pande, Davut Pehlivan, Archana Rai, Edgar Andres Rivera-Munoz, Aniko Sabo, Evette Scott, Vernon Reid Sutton, Kimberly Walker, Lauren Westerfield, Jiaoyang Xu, Bo Yuan, Xinchang Zheng, Siwaar Abouhala, K. D. Ahlquist, Mutaz Amin, Christina Austin-Tse, Samantha M. Baxter, Benjamin Blankenmeister, Philip M. Boone, Harrison Brand, Colleen Carlston, Celine de Esch, Stephanie DiTroia, Michael Duyzend, Vijay Ganesh, Kiran Garimella, Carmen Glaze, Emily Groopman, Sanna Gudmundsson, Stacey Hall, Yongqing Huang, Julia Klugherz, Katie Larsson, Arthur S. Lee, Gabrielle Lemire, Jialan Ma, Daniel MacArthur, Brian Mangilog, Daniel Marten, Eva Martinez, Olfa Messaoud, Chloe Mighton, Mariana Moyses, Ashana Neale, Emily O’Heir, Melanie C. O’Leary, Ikeoluwa Osei-Owusu, Lynn Pais, Alicia Pham, Lindsay Romo, Kathryn Russell, Monica Salani, Kaitlin Samocha, Alba Sanchis-Juan, Jillian Serrano, Gulalai Shah, Moriel Singer-Berk, Mugdha Singh, Hana Snow, Kayla Socarras, Sarah L. Stenton, Jui-Cheng Tai, Grace VanNoy, Ben Weisburd, Michael Wilson, Monica Wojcik, Isaac Wong, Rachita Yadav, Emily Alsentzer, Taylor M. Arriaga, Euan A. Ashley, Themistocles Assimes, Gill Bejerano, Devon Bonner, Denver Bradley, Jennefer Carter, Clarisa Chavez Martinez, Ziwei Chen, Salil Deshpande, Sara Emami, Ivy Evergreen, Page Goddard, John Gorzynski, William Greenleaf, Rodrigo Guarischi-Sousa, Caitlin Harrington, Sohaib Hassan, Tanner D. Jensen, David Jimenez-Morales, Christopher Jin, Aimee Juan, Jessica Kain, Laura Keehan, Anshul Kundaje, Soumya Kundu, Samuel Lancaster, Shruti Marwaha, Dena R. Matalon, Lauren Meador, Hector Rodrigo Mendez, Alexander Miller, Matthew B. Neu, Thuy-mi P. Nguyen, Jonathan Nguyen, Jeren D. Olsen, Evin M. Padhi, Paul Petrowski, Astaria D. Podesta, Elizabeth Porter, Wanqiong Qiao, Thomas Quertermous, Chloe M. Reuter, Oriane Rubio, Stuart A. Scott, Riya Sinha, Kevin S. Smith, Michael P. Snyder, Brigitte Stark, Suchitra Sudarshan, Raquel L. Summers, Christina G. Tise, Philip Tsao, Isabella Voutos, Juliana M. Walrod, Ziming Weng, Frank Wong, Yao Yang, Jiye Yu, Jimmy Zhen, Miguel Almalvez, Light Auriga, Rebekah Barrick, Sami Belhadj, Krista Bluske, Leandros Boukas, Andrea J. Cohen, Ya Cui, Ivan De Dios, Meghan Delaney, John Harting, Yun-Hua Hsiao, Rachid Karam, Charles Hadley King, Arthur Ko, Wei Li, Bojan Losic, Georgia Pitsava, Changrui Xiao, Kailyn Anderson, Peter Anderson, Sabrina Best, Elizabeth E. Blue, Kati J. Buckingham, Silvia Casadei, Yong-Han Hank Cheng, Colleen P. Davis, Sophia B. Gibson, William W. Gordon, Jonas Gustafson, William T. Harvey, Martha Horike-Pyne, Gail P. Jarvik, Annelise Y. Mah-Som, Colby T. Marvin, F. Kumara Mastrorosa, Sean R. McGee, Heather C. Mefford, Karynne Patterson, Matthew Richardson, Adriana E. Sedeño Cortés, Joshua D. Smith, Olivia M. Sommerland, Lea M. Starita, Andrew B. Stergachis, Elliott G. Swanson, Jeffrey Weiss, Qian Yi, Christina Zakarian, Miranda P. Zalusky, Emily Bonkowski, Sarah Conner, Matthew P. Conomos, Stephanie M. Gogarten, Sarah C. Nelson, Sheryl Payne, Jaime Prosser, Guanghao Qi, Adrienne M. Stilp, Catherine C. Tong, Quenna Wong, Sara Currin, Gabrielle C. Villard

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09613-8The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

Nature

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

mercredi 12 novembre 2025 par Fengxiang Wang, Cuiji Sun, Tianshu William Wu, Yuting Fu, Yujing Fan, Shuchang Zhao, Kaiyin Huang, Zijian Pan, Yang Lu, Jingrong Regina Han, Shikai Jia, Lizhou Zeng, Sheng Zhang, Ting Chen, Shaowei An, Shuang Susie Meng, Xun Guo, Weizhe Li, Heyuan Lian, Xiaoting Sun, Jin Hu, Chuanzhen Yang, Shan Feng, Pengfei Li, Liyuan Du, Xiaodong Liu, Kiryl D. Piatkevich, Yilong Zou

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09734-0Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification (...)

Nature

Extreme rainfall poses the biggest risk to Mumbai’s most vulnerable people

mercredi 12 novembre 2025 par Subimal Ghosh

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03453-2An assessment of death rates in India’s coastal megacity of Mumbai reveals the impact of rain, high tides and flooding. Climate change will probably exacerbate the (...)

Nature

Global greenhouse-gas emissions are still rising: when will they peak?

mercredi 12 novembre 2025 par Jeff Tollefson

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03618-zScientists say emissions could begin to decline in the next several years. What happens in China could determine when.

Nature

Can UK science really spawn a $1-trillion company?

mercredi 12 novembre 2025 par David Adam

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03700-6The British government wants the country to be home to a supersized tech firm within the next decade.

Nature

Mathematicians put AI model AlphaProof to the test

mercredi 12 novembre 2025 par Talia Ringer

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03585-5Mathematicians use computational tools to prove theorems. An AI model that is trained to use these tools might accelerate mathematical discovery.

Nature

Influential list of highly cited researchers now shuts out more scientists: here’s why

mercredi 12 novembre 2025 par Nicola Jones

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03691-4Rule change weeds out many who co-author papers with others linked to suspicious practices.

Nature

Material system enhances superconducting qubits

mercredi 12 novembre 2025

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03644-xIn the development of large-scale quantum processors, material improvements yield rapid progress because they can be readily translated to many devices and platforms. This work shows that, if they are built from tantalum (...)

Nature