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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair

mercredi 1er avril 2026 par Wenlong Xia, Laura Morcom, Zhaoyang Xu, I-Ling Lu, Qing Wang, Kimberly K. Hoi, Mingming Wei, Keying Zhu, Gregory Jordan, Xiao-Yan Tang, Julio Gonzalez-Maya, Vanesa S. Mattera, Sophia M. Panigrahi, Riki Kawaguchi, Ben Emery, Santos J. Franco, Daniel H. Geschwind, Brian Popko, David H. Rowitch, Stephen P. J. Fancy

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during (...)

Nature

Investigating the replicability of the social and behavioural sciences

mercredi 1er avril 2026 par Andrew H. Tyner, Anna Lou Abatayo, Mason Daley, Samuel Field, Nicholas Fox, Noah A. Haber, Krystal M. Hahn, Melissa Kline Struhl, Brinna Mawhinney, Olivia Miske, Priya Silverstein, Courtney K. Soderberg, Theresa Stankov, Ahmed Abbasi, Christopher L. Aberson, Balazs Aczel, Matúš Adamkovi?, Nihan Albayrak, Peter J. Allen, Michael Andreychik, Eli Awtrey, Erick Axxe, Flavio Azevedo, Miles D. Bader, Bence Bago, James Bailey, Marjan Bakker, Gabriel Banik, George C. Banks, Ernest Baskin, Anatolia Batruch, Annika Beatteay, Sophie M. Behr, Nicholas Berente, Zachariah Berry, J?drzej Bia?kowski, Bojana Bodroža, Laura Boeschoten, Miklos Bognar, Christian Bokhove, Diane Bonfiglio, Robin Bouwman, Timothy F. Brady, Scott R. Braithwaite, Gabriel Briceño Jiménez, Cameron Brick, Traci Bricka, Roman Briker, Annette N. Brown, Gordon D. A. Brown, Robbie C. M. van Aert, Kathryn Caldwell, Sara Capitan, Tabaré Capitán, Jesse Chandler, Tessa Charles, Christopher R. Chartier, Rahul Chawdhary, Kent Jason Cheng, William J. Chopik, Bruce Clark, Victoria E. Colvin, C. Cozette Comer, Giulio Costantini, Tom Coupé, Jamie Cummins, Aneta Czernatowicz-Kukuczka, Joshua de Leeuw, David Dobolyi, James N. Druckman, Jianhua Duan, Marin Dujmovi?, Daniel J. Dunleavy, Patrick K. Durkee, Cécile Emery, Kevin M. Esterling, Thomas R. Evans, Anna Fedor, Belén Fernández-Castilla, Nathan Fiala, James G. Field, Nathan Fong, Miguel A. Fonseca, Alexandra L. J. Freeman, Jeremy Freese, Sandra J. Geiger, Jing Geng, Laura M. Getz, Linda Marjoleine Geven, Ilka Helene Gleibs, Donna Pamella Gonzales, Janaki Gooty, Amélie Gourdon-Kanhukamwe, Cristina Greculescu, Siobhán M. Griffin, Lusine Grigoryan, Martina Grunow, Nicholas Gunby, Braeden Hall, Paul H. P. Hanel, Erin E. Hannon, Sam Harper, Marco Jürgen Held, Louis Hickman, Nathan C. Higgins, Svenja Hippel, Sven Hoeppner, Sanghyun Hong, Thomas J. Hostler, Michael Inzlicht, Kamil Izydorczak, Bastian Jaeger, Kristin Jankowsky, Johannes Jarke-Neuert, Matthew Jensen, Biljana Joki?, Daniel Jolles, Phillip Jolly, Angela M. Jones, Marie Juanchich, Pavol Ka?már, Hansika Kapoor, Andjela Keljanovic, Samjhana Koirala, Marta Ko?czy?ska, Dimitra Kouroupaki, Ulrich Kühnen, Michelangelo Landgrave, Michael J. Larson, Lyonel Laulié, Alice C. E. Lawrence, Joel M. Le Forestier, Katelin E. Leahy, Sungmok Lee, Jared Leslie, Savannah C. Lewis, Christopher Limnios, Hause Lin, An-Chiao Liu, John Wills Lloyd, Elliot A. Ludvig, Dermot Lynott, Jordan MacDonald, Peter Mallik, Daniel J. Mallinson, Daniele Marinazzo, Corinna S. Martarelli, Joshua Matacotta, Andrew McBride, Cillian McHugh, Gail McMillan, Esteban Méndez, Mitchell Metzger, Michalis P. Michaelides, Johannes Michalak, Leticia Micheli, Jeremy K. Miller, Marina Milyavskaya, Daniel C. Molden, Ambar G. Monjaras, David Moreau, Audrey Morrow, Cristóbal Moya, Liad Mudrik, Laetitia B. Mulder, Katie A. Munt, Arijit Nandi, Kathryn Nason, Carolin Nast, Gideon Nave, Heinrich H. Nax, Florian Neubauer, Phuong Linh L. Nguyen, Austin Lee Nichols, Gustav Nilsonne, Ernest O’Boyle, Jule Oettinghaus, Jeewon Oh, Adoril Oshana, Thomas Ostermann, Rachel P. Ostrowski, Abiola Oyebanjo, Radoslaw Panczak, Jamie Patrianakos, Ignacio Pavez, Yuri G. Pavlov, Sofia Persson, Marco Perugini, Kim Peters, Constant Pieters, Vladimir Ponizovskiy, Nathaniel D. Porter, Jason M. Prenoveau, Danka Puri?, Mariah F. Purol, Arathy Puthillam, Kimberly A. Quinn, Marco Ramljak, W. Robert Reed, Michaela Ritchie, Margaret Ritzau, Sean Patrick Roche, Romina Rodela, Jan Philipp Röer, Ivan Ropovik, Jacob Rothschild, Justine Saal, Hani Safadi, Jason Samaha, Mary Sanchez, Soorya Sankaran, David Santos, Amanda C. Sargent, Marian Sauter, Kathleen Schmidt, Landon Schnabel, Amber N. Schroeder, Sebastian W. Schuetz, Brendan A. Schuetze, Michael Schulte-Mecklenbeck, Astrid Schütz, Eric L. Sevigny, Ellie Shackleton, Richard M. Shafranek, Samuel Shaki, Shishir Shakya, Miroslav Sirota, Matthew Ryan Sisco, Maksim M. Sitnikov, L. Robert Slevc, Laura Smalarz, Colin Tucker Smith, Joel S. Snyder, Nicolas Sommet, Fatih Sonmez, Barbara A. Spellman, Natalia Stanulewicz-Buckley, George Stock, Chris N. H. Street, Eirik Strømland, Tina Sundelin, Moin Syed, Anna Szabelska, Barnabas Szaszi, Ewa Szumowska, Anirudh Tagat, Susanne Täuber, Louis Tay, Stuti Thapa, Jason Thatcher, Domna Tsaklakidou, Lars Tummers, Elise Turkovich, Melba Verra Tutor, Karolina Urbanska, Anna Elisabeth van ’t Veer, Marcel van Assen, Niels van de Ven, Ruben van den Goorbergh, Elisabeth Julie Vargo, Leigh Ann Vaughn, Simine Vazire, Jentien M. Vermeulen, Diem Thi Hong Vo, Victor Volkman, Eric-Jan Wagenmakers, Deliah Wagner, Lukasz Walasek, Frank Walter, Lara Warmelink, Liuqing Wei, Marie Isabelle Weißflog, Nicholas Weller, Aaron L. Wichman, Jonathan Wilbiks, Jamal R. Williams, Kelly Wolfe, Finnian Wort, Ryan Wright, Jesper N. Wulff, Xindong Xue, Veronica X. Yan, Yuzhi Yang, Sangsuk Yoon, Iris Žeželj, Yinxian Zhang, Ignazio Ziano, Cristina Zogmaister, Zorana Zupan, Rolf A. Zwaan, Brian A. Nosek, Timothy M. Errington

Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-yA large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original (...)

Nature

Evidence of the pair-instability gap from black-hole masses

mercredi 1er avril 2026 par Hui Tong, Maya Fishbach, Eric Thrane, Matthew Mould, Thomas A. Callister, Amanda M. Farah, Nir Guttman, Sharan Banagiri, Daniel Beltran-Martinez, Ben Farr, Shanika Galaudage, Jaxen Godfrey, Jack Heinzel, Marios Kalomenopoulos, Simona J. Miller, Aditya Vijaykumar

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary (...)

Nature

Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome

mercredi 1er avril 2026 par Jianping Liu, Jing Zhao, Jiayang Gao, Kun Zhao, Yaoyao Han, Jing Yang, Zefei Li, Jianyu Ye, Ziyu Sun, Fengyi Wang, Xinyi Liu, Zekai Li, Siyu Ji, Bo Liu, Cong Liu, Yixiao Zhang, Junying Yuan, James J. Chou

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB (...)

Nature

Moiré engineering of Cooper-pair density modulation states

mercredi 1er avril 2026 par Zihao Wang, Bing Xia, Stephen Paolini, Zi-Jie Yan, Pu Xiao, Jiatao Song, Veer Gowda, Hongtao Rong, Di Xiao, Xiaodong Xu, Weida Wu, Ziqiang Wang, Cui-Zu Chang

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10325-wResearchers created a moiré superlattice in Sb2Te3/FeTe bilayers, producing spatially modulated superconducting gaps directly imaged with Josephson scanning tunnelling microscopy and spectroscopy, tunable by replacing Sb2Te3 (...)

Nature

Investigating the reproducibility of the social and behavioural sciences

mercredi 1er avril 2026 par Olivia Miske, Anna Lou Abatayo, Mason Daley, Mirka Dirzo, Nicholas Fox, Noah Haber, Krystal M. Hahn, Melissa Kline Struhl, Brinna Mawhinney, Priya Silverstein, Theresa Stankov, Andrew H. Tyner, Matúš Adamkovi?, Shilaan Alzahawi, Saule Anafinova, Eli Awtrey, Erick Axxe, James Bailey, Bert N. Bakker, Akshaya Balaji, Gabriel Banik, František Bartoš, Henk Berkman, Zachariah Berry, Felix S. Bethke, Timothy F. Brady, Nate Breznau, Sara Capitan, Tabaré Capitán, Laura Caquelin, Kent Jason Cheng, William J. Chopik, Gwen-Jiro Clochard, Tom Coupé, Jamie Cummins, Elif Gizem Demirag Burak, Jianhua Duan, Kevin M. Esterling, Thomas R. Evans, Nathan Fiala, James Field, Victor Gay, Jing Geng, Johanna Gereke, Ilka Helene Gleibs, Amélie Gourdon-Kanhukamwe, Dmitry Grigoryev, Nicholas Gunby, Paul H. P. Hanel, Sanghyun Hong, Sean Dae Houlihan, Nick Huntington-Klein, Kamil Izydorczak, Kristin Jankowsky, Kai Jonas, Pavol Ka?már, Hansika Kapoor, Sebastian Karcher, Marta Ko?czy?ska, David Kretschmer, Ljiljana Lazarevic, Katelin E. Leahy, Jessica C. Lee, Christopher Limnios, An-Chiao Liu, John Wills Lloyd, Ruben Lopez-Nicolas, Nigel Mantou Lou, Richard E. Lucas, Maximilian Maier, Daniel J. Mallinson, Marcel Marton?ik, Michael C. McCall, Nikita Mehta, Esteban Méndez, Johannes Michalak, Daniel C. Molden, Faisal Mushtaq, Claudia Neuendorf, Austin Lee Nichols, Gustav Nilsonne, Ernest O’Boyle, Jeewon Oh, Thomas Ostermann, Abiola Oyebanjo, Radoslaw Panczak, Yuri G. Pavlov, Zoran Pavlovi?, Noemi Peter, Kim Peters, Nathaniel D. Porter, Mariah Purol, Arathy Puthillam, Marco Ramljak, Arran T. Reader, W. Robert Reed, Jan Philipp Röer, Ivan Ropovik, Alexander O. Savi, Kathleen Schmidt, Landon Schnabel, Eric L. Sevigny, Samuel Shaki, Shishir Shakya, Andrew Soh, Angela Somo, Fatih Sonmez, Eirik Strømland, Jordan W. Suchow, Anna Szabelska, Anirudh Tagat, Melba Verra Tutor, Karolina Urbanska, Pieter Van Dessel, Elisabeth Julie Vargo, Diem Thi Hong Vo, Victor Volkman, Ke Wang, Aaron L. Wichman, Jamal R. Williams, Fabian Winter, Ferdinand Wintermantel, Nan Zhang, Ignazio Ziano, Cristina Zogmaister, Zorana Zupan, Brian A. Nosek, Timothy M. Errington

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers (...)

Nature

Substantial aircraft contrail formation at low soot emission levels

mercredi 1er avril 2026 par Christiane Voigt, Raphael Märkl, Daniel Sauer, Rebecca Dischl, Charles Renard, Katharina Seeliger, Fangqun Yu, Stefan Kaufmann, Tiziana Bräuer, Tina Jurkat-Witschas, Gauthier Le Chenadec, Julien Moreau, Emiliano Requena-Esteban, Nicolas Bonne, Margaux Vals, Amandine Roche, Joseph Zelina, Andreas Dörnbrack, Lisa Eirenschmalz, Christopher Heckl, Elisabeth Horst, Michael Lichtenstern, Andreas Marsing, Gregor Neumann, Anke Roiger, Monika Scheibe, Paul Stock, Andreas Giez, Georg Eckel, Patrick Le Clercq

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10286-0In-flight observations show that the use of lean-burn combustion succeeds in reducing soot emissions from aircraft—yet contrail ice crystals still form and nucleate on volatile (...)

Nature

A µ-opioid receptor superagonist analgesic with minimal adverse effects

mercredi 1er avril 2026 par Juan L. Gomez, Emilya N. Ventriglia, Zachary J. Frangos, Agnieszka Sulima, Michael J. Robertson, Michael D. Sacco, Reece C. Budinich, Ilinca M. Giosan, Tongzhen Xie, Oscar Solis, Anna E. Tischer, Jennifer M. Bossert, Kiera E. Caldwell, Hannah Bonbrest, Amelie Essmann, Zelai M. Garçon-Poca, Shinbe Choi, Michael R. Noya, Feonil Limiac, Ali Arce, Grant C. Glatfelter, Margaret Robinson, Li Chen, Angelina A. Mullarkey, Dain R. Brademan, Garrett Enten, William Dunne, César Quiroz, Ingrid Schoenborn, Chae Bin Lee, Rana Rais, Daniel P. Holt, Robert F. Dannals, Lei Shi, Ruth Hüttenhain, Sergi Ferré, Eugene Kiyatkin, Jordi Bonaventura, Yavin Shaham, Venetia Zachariou, Michael H. Baumann, Georgios Skiniotis, Kenner C. Rice, Michael Michaelides

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent (...)

Nature

Dopaminergic mechanisms of dynamical social specialization

mercredi 1er avril 2026 par C. Solié, A. Nicolson, R. Justo, Y. Layadi, B. Morin, C. Batifol, L. M. Reynolds, T. Le Borgne, S. L. Fayad, A. Gulmez, Y. Rodriguez Quevedo, J. Allegret-Vautrot, G. Centene Guglielmi, F. de Chaumont, S. Didienne, N. Debray, J.-P. Hardelin, B. Girard, A. Mourot, J. Naudé, C. Viollet, F. Marti, B. Delord, Ph. Faure

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10301-4Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving sex-divergent patterns (...)

Nature

Developmental organization of sensory and sympathetic ganglia

mercredi 1er avril 2026 par Keng Ioi Vong, Yanina D. Alvarez, Qingquan Zhang, Jiaming Weng, Geoffroy Noel, Scott T. Barton, Changuk Chung, Robyn Howarth, Naomi Meave, Fiza Jiwani, Sai B. Patarlapalli, Fenyong Yao, Fugui Zhu, Chelsea Barrows, Arzoo Patel, Jian Xiong Wang, Neil C. Chi, Stephen F. Kingsmore, Melanie D. White, Xiaoxu Yang, Joseph G. Gleeson

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic (...)

Nature