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AI-redesigned starting points and outcomes enhance protein evolution

mercredi 22 juillet 2026 par Nicholas A. Krasnow, Joy A. Xu, Emily Zhang, Gandhar K. Mahadeshwar, Y. Allen Tao, Julia McCreary, Colin F. Hemez, Logan E. Brown, Wei Jiang, David R. Liu

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10820-0A workflow using artificial intelligence-redesigned starting points to evolve enzymes with improved properties compared with those evolved from natural proteins is (...)

Nature

The planktonic microbiome of the Great Barrier Reef

mercredi 22 juillet 2026 par Steven Robbins, Marko Terzin, Katherine Dougan, Julian Zaugg, Sara C. Bell, Patrick W. Laffy, J. Pamela Engelberts, Kim-Anh Lê Cao, Renee K. Gruber, Nicole S. Webster, David G. Bourne, Philip Hugenholtz, Yun Kit Yeoh

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10778-zThe Great Barrier Reef Microbial Genomes Database compiles prokaryotic, viral and eukaryotic genomes from seawater collected from the Great Barrier Reef, providing a rich resource for the study of marine microbial communities (...)

Nature

A global molecular code for birth order and neuronal identity in Drosophila

mercredi 22 juillet 2026 par Sebastian Cachero, Myrto Mitletton, Isabella R. Beckett, Elizabeth C. Marin, Laia Serratosa Capdevila, Marina Gkantia, Jelly H. M. Soffers, Haluk Lacin, Gregory S. X. E. Jefferis, Erika Donà

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10797-wA high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal birth order and organizes neuronal (...)

Nature

Subnuclear genome compartmentalization controls bivalent chromatin activity

mercredi 22 juillet 2026 par Sajad Hamid Ahanger, Evan R. Semenza, Chujing Zhang, Eugene Gil, Mitchel A. Cole, Serena Huei-An Lu, Li Wang, Arnold R. Kriegstein, Daniel A. Lim

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10832-wKnowledge of the spatial location of a gene is necessary to understand its epigenomic regulation.

Nature

Non-Gaussian statistics of the order parameter across a phase transition

mercredi 22 juillet 2026 par Maxime Allemand, Géraud Dupuy, Paul Paquiez, Nicolas Dupuis, Adam Rançon, Tommaso Roscilde, Thomas Chalopin, David Clément

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10811-1Single-atom measurements show non-Gaussian order-parameter fluctuations and critical scaling across a continuous phase transition, highlighting the importance of full statistical distributions in understanding (...)

Nature

Imaging of nanoscale polar textures in quantum paraelectric SrTiO₃

mercredi 22 juillet 2026 par Yang Zhang, Suk Hyun Sung, Nishkarsh Agarwal, Maya Gates, Cong Li, Pu Yu, Robert Hovden, Ismail El Baggari

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10823-xCryo-STEM reveals that SrTiO3 forms periodic polar nanodomains below 105 K, but these fragment below 40 K, linking quantum paraelectricity to nanoscale polar ordering and (...)

Nature

Exceptional brain and ecological diversity in the earliest snakes

mercredi 22 juillet 2026 par Tiago R. Simões, Gabriela Sobral, Simone Macrì, Roy Ebel, Thiago S. Fachini, Agustín G. Martinelli, William R. Nava, Giovanna M. X. Paixão, Luis M. Chiappe, Nicolas Di-Poï, Annie S. Hsiou

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10809-9A well-preserved fossil snake from the Late Cretaceous of Brazil shows early ecological and brain shape disparity in the group.

Nature

Brown bullhead catfish melanoma represents a novel transmissible cancer

mercredi 22 juillet 2026 par Emily E. Curd, Samuel F. M. Hart, James Lubkowitz, Kirsten M. Tracy, Lucas Milazzo, Matthew Bodnar, Tom Jones, Mark J. Henderson, Peter Emerson, Julie A. Dragon

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10828-6Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible (...)

Nature

Semiconducting and magnetic lanthanide MXenes from intercalated halides

mercredi 22 juillet 2026 par Qian Fang, Liming Wang, Kai Chang, Hongxin Yang, Pu Yan, Kecheng Cao, Mian Li, Jianming Xue, Xiaoping Ouyang, Zhifang Chai, Qing Huang

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10802-2A bottom-up synthesis strategy creates lanthanide MXenes (Ln2CT2) that combine semiconducting behaviour with ferromagnetism, offering a promising new class of two-dimensional materials for spintronic (...)

Nature

Efficient and precise programmable DNA knock-in without double-strand breaks

mercredi 22 juillet 2026 par Yanmin Gao, Yu Ma, Kexin Yu, Yintian Liu, Buming Gu, Hao Tang, Wenjie Yan, Shuangshuang Yang, Jingran Su, Xindong Wang, Xin Ma, Xinming Wang, Fang Wang, Qingyang Li, Mengying Liu, Haifeng Wang

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted (...)

Nature