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Triplets electrically turn on insulating lanthanide-doped nanoparticles

mercredi 19 novembre 2025 par Zhongzheng Yu, Yunzhou Deng, Junzhi Ye, Lars van Turnhout, Tianjun Liu, Alasdair Tew, Rakesh Arul, Simon Dowland, Yuqi Sun, Xinjuan Li, Linjie Dai, Yang Lu, Caterina Ducati, Jeremy J. Baumberg, Richard H. Friend, Robert L. Z. Hoye, Akshay Rao

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09601-yTo turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical excitation pathway coupling them to organic optical molecules to form nanohybrids is described, enabling tunable (...)

Nature

A skin-permeable polymer for non-invasive transdermal insulin delivery

mercredi 19 novembre 2025 par Qiuyu Wei, Zhi He, Zifan Li, Zhuxian Zhou, Ying Piao, Jianxiang Huang, Yu Geng, Runnan Zhang, Yaqi Fu, Jiayi Ye, Yue Yuan, Haoru Zhu, Jiaheng Zeng, Yan Zhang, Quan Zhou, Mingyu Xu, Shiqun Shao, Jianbin Tang, Jiajia Xiang, Rongjun Chen, Ruhong Zhou, Youqing Shen

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09729-xThe fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protein- and peptide-based (...)

Nature

Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing

mercredi 19 novembre 2025 par Zidan Yang, Miho Inagaki, Charles R. Gerfen, Lorenzo Fontolan, Hidehiko K. Inagaki

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09778-2How the mouse frontal cortex and striatum interact to implement integrator dynamics controlling movement timing is explored.

Nature

Hepatic zonation determines tumorigenic potential of mutant ?-catenin

mercredi 19 novembre 2025 par Alexander Raven, Kathryn Gilroy, Hu Jin, Joseph A. Waldron, Holly Leslie, June Munro, Holly Hall, Rachel A. Ridgway, Catriona A. Ford, Doga C. Gulhan, Nikola Vlahov, Megan L. Mills, Andrew Hartley, Eve Anderson, Sheila Bryson, Nathalie Sphyris, Miryam Müller, Stephanie May, Barbara Cadden, Colin Nixon, Scott H. Waddell, Rachel Guest, Luke Boulter, Nick Barker, Hans Clevers, Hao Zhu, Johanna Ivaska, Douglas Strathdee, Crispin J. Miller, Nigel B. Jamieson, Martin Bushell, Peter J. Park, Thomas G. Bird, Owen J. Sansom

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09733-1Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.

Nature

Repulsions instruct synaptic partner matching in an olfactory circuit

mercredi 19 novembre 2025 par Zhuoran Li, Cheng Lyu, Chuanyun Xu, Ying Hu, David J. Luginbuhl, Asaf B. Caspi-Lebovic, Jessica M. Priest, Engin Özkan, Liqun Luo

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09768-4Transcriptomic screening identifies pairs of cell-surface proteins that mediate repulsive interactions between axons and dendrites of non-cognate partner neurons, thereby contributing to correct synaptic partner (...)

Nature

Structural basis of regulated N-glycosylation at the secretory translocon

mercredi 19 novembre 2025 par Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J. Keenan

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09756-8The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC134-bound translocon is described, revealing how the nascent chain remodels the translocon to control N-glycosylation by (...)

Nature

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples

mercredi 19 novembre 2025 par Sofía Ibáñez-Molero, Johanna Veldman, Juan Simon Nieto, Joleen J. H. Traets, Austin George, Kelly Hoefakker, Anita Karomi, Rolf Harkes, Bram van den Broek, Su Min Pack, Liselotte Tas, Nils L. Visser, Susan E. van Hal-van Veen, Paula Alóndiga-Mérida, Maartje Alkemade, Iris M. Seignette, Renaud Tissier, Marja Nieuwland, Martijn van Baalen, Joanna Po?niak, Erik Mul, Simon Tol, Sofia Stenqvist, Lisa M. Nilsson, Jonas A. Nilsson, John B. A. G. Haanen, Winan J. van Houdt, Daniel S. Peeper

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09754-wTumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical (...)

Nature

Semantic design of functional de novo genes from a genomic language model

mercredi 19 novembre 2025 par Aditi T. Merchant, Samuel H. King, Eric Nguyen, Brian L. Hie

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09749-7By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined activities, whose (...)

Nature

ZAK activation at the collided ribosome

mercredi 19 novembre 2025 par Vienna L. Huso, Shuangshuang Niu, Marco A. Catipovic, James A. Saba, Timo Denk, Eugene Park, Jingdong Cheng, Otto Berninghausen, Thomas Becker, Rachel Green, Roland Beckmann

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09772-8The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Nature

Prime editing-installed suppressor tRNAs for disease-agnostic genome editing

mercredi 19 novembre 2025 par Sarah E. Pierce, Steven Erwood, Keyede Oye, Meirui An, Nicholas Krasnow, Emily Zhang, Aditya Raguram, Davis Seelig, Mark J. Osborn, David R. Liu

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09732-2A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop (...)

Nature