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Prime assembly with linear DNA donors enables large genomic insertions

mercredi 29 avril 2026 par Bin Liu, Andrew Petti, Xuntao Zhou, Haoyang Cheng, Jenny Gao, Matthew Yee, Youwei Qiao, Yanjun Zhang, Lin Zhou, Scot A. Wolfe, Tingting Jiang, Erik J. Sontheimer, Wen Xue

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10460-4Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed (...)

Nature

Charge-dependent spectral softenings of primary cosmic rays below the knee

mercredi 29 avril 2026 par Francesca Alemanno, Qi An, Philipp Azzarello, Felicia-Carla-Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Hugo Boutin, Irene Cagnoli, Ming-Sheng Cai, Elisabetta Casilli, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Zi-Xuan Chen, Paul Coppin, Ming-Yang Cui, Tian-Shu Cui, Ivan De Mitri, Francesco de Palma, Adriano Di Giovanni, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, Jing-Lai Duan, Kai-Kai Duan, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Sara Fogliacco, Jennifer-Maria Frieden, Piergiorgio Fusco, Min Gao, Fabio Gargano, Essna Ghose, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Lu-Yao Jiang, Wei Jiang, Yao-Zu Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Bo Li, Manbing Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario-Nicola Mazziotta, Dan Mo, Yu Nie, Xiao-Yang Niu, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Enzo Putti-Garcia, Rui Qiao, Jia-Ning Rao, Yi Rong, Ritabrata Sarkar, Pierpaolo Savina, Andrea Serpolla, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Gui-Fu Wang, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Xiao-Lian Wang, Yan-Fang Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, Zheng Xiong, En-Heng Xu, Hai-Tao Xu, Jing Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Ming-Yu Yan, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Ya-Peng Zhang, Yi Zhang, Yong-Jie Zhang, Yong-Qiang Zhang, Yun-Long Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Xun Zhu, Yan Zhu

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10472-0The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% (...)

Nature

Uncertain dynamic response of mid-latitude winter precipitation

mercredi 29 avril 2026 par Lei Gu, Dominik L. Schumacher, Sebastian Sippel, Erich M. Fischer, Istvan Dunkl, Robin Noyelle, Jitendra Singh, Lorenzo Pierini, Reto Knutti

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10474-ySeparating the anthropogenic forced thermodynamic and dynamic components from internal variability in winter precipitation trends in the mid-latitudes shows that thermodynamic effects agree with models and observations but (...)

Nature

Higher-order interactions enhance the latitudinal tree diversity gradient

mercredi 29 avril 2026 par Yuanzhi Li, Junli Xiao, Yuan Jiang, Stuart Joseph Wright, Margaret M. Mayfield, Oscar Godoy, Alfonso Alonso, Kristina J. Anderson-Teixeira, Jennifer Baltzer, Joseph D. Birch, Pulchérie Bissiengou, Norman A. Bourg, Warren Brockelman, David F. R. P. Burslem, Min Cao, Keith Clay, Stuart J. Davies, Qingqing Du, Sisira Ediriweera, Anna Feistner, Edwino S. Fernando, Gregory S. Gilbert, Zhanqing Hao, Jan Holík, Mingxi Jiang, Guangze Jin, Daniel J. Johnson, Alexander S. Jones, Kamil Král, Andrew J. Larson, Buhang Li, Juyu Lian, Luxiang Lin, Feng Liu, Yu Liu, Zhili Liu, James A. Lutz, Keping Ma, Sean M. McMahon, William McShea, Hervé Roland Memiaghe, Xiangcheng Mi, Jonathan A. Myers, Musalmah Nasardin, Anuttara Nathalang, Michael J. O’Brien, Nestor Laurier Engone Obiang, Geoffrey Parker, Richard P. Phillips, Xiujuan Qiao, Haibao Ren, Glen Reynolds, Lillian Jennifer V. Rodriguez, Pavel Šamonil, Guochun Shen, Zufei Shu, Jessica Shue, Mark E. Swanson, Jill Thompson, María Uriarte, Xihua Wang, Xugao Wang, Youshi Wang, Tze Leong Yao, Wanhui Ye, Mingjian Yu, Minhua Zhang, Yan Zhu, Jess Zimmerman, Fangliang He, Chengjin Chu

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10434-6Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global forests, potentially explaining why this intricate phenomenon cannot be adequately explained by (...)

Nature

The past, present and future of de novo protein design

mercredi 29 avril 2026 par Wei Yang, Shunzhi Wang, Gyu Rie Lee, Jason Z. Zhang, Alexis Courbet, David Juergens, Xinru Wang, Thomas Schlichthaerle, Mohamad Abedi, Robert Ragotte, Linna An, Indrek Kalvet, Sam Pellock, Ljubica Mihaljevic, Cameron Glasscock, Arvind Pillai, Adam Broerman, Nathan Ennist, Ella Haefner, Nora McNamara-Bordewick, Ian Haydon, Lance Stewart, Gaurav Bhardwaj, David Baker

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10328-7A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.

Nature

GLP-1R–GIPR–PPAR?/?/? quintuple agonism corrects obesity and diabetes in mice

mercredi 29 avril 2026 par Daniela Liskiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin, Jonathan E. Campbell, Pietra Candela, Russell L. Castelino, Callum Coupland, Maxime Culot, W. Scott Dodson, Jonathan D. Douros, Hannes Embring, Annette Feuchtinger, Brian Finan, Cristina Garcia-Caceres, Xiao-Bing Gao, Fabien Gosselet, Gerald Grandl, Robert M. Gutgesell, Daniel T. Haas, Martin Jastroch, Ezgi Karaoglu, Pamela Kakimoto, Anna Cristina Kaltenbach, Michaela Keuper, Christine M. Kusminski, Danielle C. Leander, Arkadiusz Liskiewicz, Xue Liu, Gandhari Maity-Kumar, Sara Martinez Martinez, Stephanie A. Mowery, Ruben Nogueiras, Marshall Paisley, Diego Perez-Tilve, Patricia S. S. Petersen, Paul T. Pfluger, Sneha Prakash, Sabine Steffens, Alberto Cebrian-Serrano, Monica Tost, Jordan Wean, Christian Weber, Junichi Yoshida, Zachary Gerhart-Hines, Tamas L. Horvath, Philipp E. Scherer, Randy J. Seeley, Richard D. DiMarchi, Matthias H. Tschöp, Natalie Krahmer, Patrick J. Knerr, Timo D. Müller

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin (...)

Nature

Increase in wild animal consumption across Central Africa

mercredi 29 avril 2026 par Mattia Bessone, Daniel J. Ingram, Katharine Abernethy, Sylvanus Abua, Sophie Allebone-Webb, Daniela Antonacci, Riyong Kim, Stephanie Brittain, Daniel Cornelis, Diane Detoeuf, Charles A. Emogor, Julia E. Fa, Steffen Foerster, Davy Fonteyn, Maria Grande Vega, Chloe Hodgkinson, Amy Ickowitz, Cédric Thibaut Kamogne Tagne, Della Kemalasari, Noëlle Kümpel, Simon Lhoest, Germain Mavah, Rodrigue Guy Mouanda Niamba, Donald Midoko Iponga, Eleanor J. Milner-Gulland, Jonas Muhindo, Théodore Munyuli, Robert Nasi, Steeve Ngama, Jonas Nyumu, Justin Ombeni, John R. Poulsen, Dominic Rowland, Yahya Sampurna, François Sandrin, Malcolm Starkey, Caleb Tata, Julius C. Tieguhong, Nathalie van Vliet, Philippe Vigneron, Robin C. Whytock, Michelle Wieland, David Wilkie, Jasmin Willis, Juliet Wright, Lauren Coad

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10422-wWild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the recommended daily protein intake, compared with 13% and 6% for those living in towns and (...)

Nature

Cytoplasmic competition between separate parental pronuclei in zygotes

mercredi 29 avril 2026 par Hirohisa Kyogoku, Mitsusuke Tarama, Masahiro Matsuwaka, Tappei Mishina, Akihito Harada, Reiko Nakagawa, Mami Kumon, Yoshihiro Shimizu, Yasuyuki Ohkawa, Tatsuo Shibata, Azusa Inoue, Tomoya S. Kitajima

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10417-7Drug-based and manipulation-based strategies provide evidence of pronuclear competition for finite cytoplasmic resources between separate parental pronuclei in zygotes, suggesting a cell biological mechanism for the (...)

Nature

Training language models to be warm can reduce accuracy and increase sycophancy

mercredi 29 avril 2026 par Lujain Ibrahim, Franziska Sofia Hafner, Luc Rocher

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10410-0Experiments on five different language models show that training language models to produce warmer responses can undermine the accuracy of their output, especially when users express feelings of (...)

Nature

Engineering tough blood clots for rapid haemostasis and enhanced regeneration

mercredi 29 avril 2026 par Shuaibing Jiang, Guangyu Bao, Zhen Yang, Jing Wu, Xingwei Yang, Joo Eun June Kim, Roselyn Jiang, Ying Zhan, Alexander Nottegar, Yin Liu, Zu-hua Gao, Andrew Beckett, Anastasia Nijnik, Rong Long, Christian Kastrup, Jianyu Li

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10412-yEngineered blood clots using rapidly crosslinked red blood cells form within seconds, greatly improving toughness and adhesion while effectively stopping bleeding and enhancing tissue (...)

Nature