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A surprising way to make heat in an unexpected part of fat cells

mercredi 17 septembre 2025

Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-02962-4Organelles called peroxisomes have been found to have a role in heat generation in fat tissue, and use a mechanism independent of the known heat-producing protein UCP1. The process involves the synthesis and degradation (...)

Nature

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

mercredi 17 septembre 2025 par Xuejing Liu, Anyuan He, Dongliang Lu, Donghua Hu, Min Tan, Abenezer Abere, Parniyan Goodarzi, Bilal Ahmad, Brian Kleiboeker, Brian N. Finck, Mohamed Zayed, Katsuhiko Funai, Jonathan R. Brestoff, Ali Javaheri, Patricia Weisensee, Bettina Mittendorfer, Fong-Fu Hsu, Paul P. Van Veldhoven, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09517-7A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue (...)

Nature

Co-option of an ancestral cloacal regulatory landscape during digit evolution

mercredi 17 septembre 2025 par Aurélie Hintermann, Christopher C. Bolt, M. Brent Hawkins, Guillaume Valentin, Lucille Lopez-Delisle, Madeline M. Ryan, Sandra Gitto, Paula Barrera Gómez, Bénédicte Mascrez, Thomas A. Mansour, Tetsuya Nakamura, Matthew P. Harris, Neil H. Shubin, Denis Duboule

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09548-0The regulatory landscape controlling Hoxd gene expression in tetrapod digit development was probably co-opted from a pre-existing cloacal regulatory mechanism, as evidenced by the effects of genetic deletion experiments (...)

Nature

Learning the natural history of human disease with generative transformers

mercredi 17 septembre 2025 par Artem Shmatko, Alexander Wolfgang Jung, Kumar Gaurav, Søren Brunak, Laust Hvas Mortensen, Ewan Birney, Tom Fitzgerald, Moritz Gerstung

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09529-3Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never seen actual (...)

Nature

Delegation to artificial intelligence can increase dishonest behaviour

mercredi 17 septembre 2025 par Nils Köbis, Zoe Rahwan, Raluca Rilla, Bramantyo Ibrahim Supriyatno, Clara Bersch, Tamer Ajaj, Jean-François Bonnefon, Iyad Rahwan

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09505-xPeople cheat more when they delegate tasks to artificial intelligence, and large language models are more likely than humans to comply with unethical instructions—a risk that can be minimized by introducing prohibitive, (...)

Nature

Structural basis for mTORC1 activation on the lysosomal membrane

mercredi 17 septembre 2025 par Zhicheng Cui, Alessandra Esposito, Gennaro Napolitano, Andrea Ballabio, James H. Hurley

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09545-3Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in (...)

Nature

Reduced Atlantic reef growth past 2 °C warming amplifies sea-level impacts

mercredi 17 septembre 2025 par Chris T. Perry, Didier M. de Bakker, Alice E. Webb, Steeve Comeau, Ben P. Harvey, Christopher E. Cornwall, Lorenzo Alvarez-Filip, Esmeralda Pérez-Cervantes, John Morris, Ian C. Enochs, Lauren T. Toth, Aaron O’Dea, Erin M. Dillon, Erik H. Meesters, William F. Precht

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09439-4An analysis of coral reefs in the tropical western Atlantic suggests that nearly all will be eroding by 2100 if global warming exceeds 2 °C, which will worsen the effects of sea-level (...)

Nature

High-density soft bioelectronic fibres for multimodal sensing and stimulation

mercredi 17 septembre 2025 par Muhammad Khatib, Eric Tianjiao Zhao, Shiyuan Wei, Jaeho Park, Alex Abramson, Estelle Spear Bishop, Anne-Laure Thomas, Chih-Hsin Chen, Pamela Emengo, Chengyi Xu, Ryan Hamnett, Samuel E. Root, Lei Yuan, Matthias J. Wurdack, Tomasz Zaluska, Yeongjun Lee, Kostas Parkatzidis, Weilai Yu, Dorine Chakhtoura, Kyun Kyu Kim, Donglai Zhong, Yuya Nishio, Chuanzhen Zhao, Can Wu, Yuanwen Jiang, Anqi Zhang, Jinxing Li, Weichen Wang, Fereshteh Salimi-Jazi, Talha A. Rafeeqi, Nofar Mintz Hemed, Jeffrey B.-H. Tok, Xiang Qian, Xiaoke Chen, Julia A. Kaltschmidt, James C. Y. Dunn, Zhenan Bao

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09481-2High-density multimodal soft bioelectronic fibres provide a platform for minimally invasive implantable electronics, where diverse sensing and stimulation functionalities can be effectively (...)

Nature

Selective presynaptic inhibition of leg proprioception in behaving Drosophila

mercredi 17 septembre 2025 par Chris J. Dallmann, Yichen Luo, Sweta Agrawal, Akira Mamiya, Grant M. Chou, Andrew Cook, Anne Sustar, Bingni W. Brunton, John C. Tuthill

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09554-2A study in Drosophila has identified a neural circuit that selectively suppress movement-encoding proprioceptors during self-generated movements such as walking and (...)

Nature

Myeloperoxidase transforms chromatin into neutrophil extracellular traps

mercredi 17 septembre 2025 par Garth Lawrence Burn, Tobias Raisch, Sebastian Tacke, Moritz Winkler, Daniel Prumbaum, Stephanie Thee, Niclas Gimber, Stefan Raunser, Arturo Zychlinsky

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09523-9Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs (...)

Nature