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Palaeometabolomes yield biological and ecological profiles at early human sites

mercredi 17 décembre 2025 par Timothy G. Bromage, Christiane Denys, Christopher Lawrence De Jesus, Hediye Erdjument-Bromage, Ottmar Kullmer, Oliver Sandrock, Friedemann Schrenk, Marc D. McKee, Natalie Reznikov, Gail M. Ashley, Bin Hu, Sher B. Poudel, Antoine Souron, Daniel J. Buss, Eran Ittah, Jülide Kubat, Sasan Rabieh, Shoshana Yakar, Thomas A. Neubert

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09843-wMetabolic and proteomic profiles derived from fossilized skeletal remains of animals enable inferences regarding physiological health and disease as well as diet to provide reconstructions of ancient soil, vegetation and (...)

Nature

Astrocyte CCN1 stabilizes neural circuits in the adult brain

mercredi 17 décembre 2025 par Laura Sancho, Matthew M. Boisvert, Trinity Eddy, Jillybeth Burgado, Minerva Contreras, Lara Labarta-Bajo, Ellen Wang, Lisa Tatsumi, Nicola J. Allen

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09770-wNeural circuits in adult mouse visual cortex are stabilized by astrocytes, which secrete CCN1, resulting in reduced plasticity and increased maturation of multiple cell (...)

Nature

An 11-qubit atom processor in silicon

mercredi 17 décembre 2025 par Hermann Edlbauer, Junliang Wang, A. M. Saffat-Ee Huq, Ian Thorvaldson, Michael T. Jones, Saiful Haque Misha, William J. Pappas, Christian M. Moehle, Yu-Ling Hsueh, Henric Bornemann, Samuel K. Gorman, Yousun Chung, Joris G. Keizer, Ludwik Kranz, Michelle Y. Simmons

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09827-wAn 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art Bell-state fidelities of up to (...)

Nature

Visualizing interaction-driven restructuring of quantum Hall edge states

mercredi 17 décembre 2025 par Jiachen Yu, Haotan Han, Kristina G. Wolinski, Ruihua Fan, Amir S. Mohammadi, Tianle Wang, Taige Wang, Liam Cohen, Kenji Watanabe, Takashi Taniguchi, Andrea F. Young, Michael P. Zaletel, Ali Yazdani

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09858-3Scanning tunnelling microscopy is used to image pristine electrostatically defined quantum Hall edge states in graphene with high spatial resolution and demonstrate their interaction-driven (...)

Nature

The global hydrogen budget

mercredi 17 décembre 2025 par Zutao Ouyang, Robert B. Jackson, Marielle Saunois, Josep G. Canadell, Yuanhong Zhao, Catherine Morfopoulos, Paul B. Krummel, Prabir K. Patra, Glen P. Peters, Fraser Dennison, Thomas Gasser, Alexander T. Archibald, Vivek Arora, Gabriel Baudoin, Naveen Chandra, Philippe Ciais, Steven J. Davis, Sarah Feron, Fangzhou Guo, Didier Hauglustaine, Christopher D. Jones, Matthew W. Jones, Etsushi Kato, Daniel Kennedy, Jürgen Knauer, Sebastian Lienert, Danica Lombardozzi, Joe R. Melton, Julia E.M.S. Nabel, Michael O’Sullivan, Gabrielle Pétron, Benjamin Poulter, Joeri Rogelj, David Sandoval Calle, Pete Smith, Parvadha Suntharalingam, Hanqin Tian, Chenghao Wang, Andy Wiltshire

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09806-1Trends in global H2 sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

Nature

Prevalence of Alzheimer’s disease pathology in the community

mercredi 17 décembre 2025 par Dag Aarsland, Anita Lenora Sunde, Diego A. Tovar-Rios, Antoine Leuzy, Tormod Fladby, Henrik Zetterberg, Kaj Blennow, Kübra Tan, Giovanni De Santis, Yara Yakoub, Burak Arslan, Hanna Huber, Ilaria Pola, Lana Grötschel, Guglielmo Di Molfetta, Håvard K. Skjellegrind, Geir Selbaek, Nicholas J. Ashton

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09841-yThe prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.

Nature

Titan’s strong tidal dissipation precludes a subsurface ocean

mercredi 17 décembre 2025 par Flavio Petricca, Steven D. Vance, Marzia Parisi, Dustin Buccino, Gael Cascioli, Julie Castillo-Rogez, Brynna G. Downey, Francis Nimmo, Gabriel Tobie, Baptiste Journaux, Andrea Magnanini, Ula Jones, Mark Panning, Amirhossein Bagheri, Antonio Genova, Jonathan I. Lunine

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09818-xReanalysis of radiometric data from Cassini indicates that Titan does not contain a subsurface ocean, as strong tidal dissipation observed in its gravity field is not consistent with the presence of a liquid (...)

Nature

Human assembloids recapitulate periportal liver tissue in vitro

mercredi 17 décembre 2025 par Lei Yuan, Sagarika Dawka, Yohan Kim, Anke Liebert, Fabian Rost, Robert Arnes-Benito, Franziska Baenke, Christina Götz, David Long Hin Tsang, Andrea Schuhmann, Anna Shevchenko, Roberta Rezende de Castro, Seunghee Kim, Aleksandra Sljukic, Anna M. Dowbaj, Andrej Shevchenko, Daniel Seehofer, Dongho Choi, Georg Damm, Daniel E. Stange, Meritxell Huch

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09884-1Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid (...)

Nature

Spatiotemporal cellular map of the developing human reproductive tract

mercredi 17 décembre 2025 par Valentina Lorenzi, Cecilia Icoresi-Mazzeo, Charlotte Cassie, Nadav Yayon, Elias R. Ruiz-Morales, Carmen Sancho-Serra, Ryan Colligan, Frederick C. K. Wong, Magda Mare?ková, Elizabeth Tuck, Kenny Roberts, Tong Li, Marc-Antoine Jacques, James Ashcroft, Xiaoling He, Berta Crespo, Batuhan Cakir, Simon Murray, Yong Gu, Alexander V. Predeus, Martin Prete, Iva Kelava, Roger Barker, Luz Garcia-Alonso, John C. Marioni, Roser Vento-Tormo

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09875-2A detailed spatiotemporal roadmap of the human female and male reproductive tracts during key periods of sexual differentiation provides new cellular and molecular insights into how early axial gradients lead to specific (...)

Nature

Lesion-remote astrocytes govern microglia-mediated white matter repair

mercredi 17 décembre 2025 par Sarah McCallum, Keshav B. Suresh, Timothy S. Islam, Manish K. Tripathi, Ann W. Saustad, Oksana Shelest, Aditya Patil, David Lee, Brandon Kwon, Katherine Leitholf, Inga Yenokian, Sophia E. Shaka, Connor H. Beveridge, Palak Manchandra, Caitlin E. Randolph, Gordon P. Meares, Ranjan Dutta, Jasmine Plummer, Vinicius F. Calsavara, Riki Kawaguchi, Simon R. V. Knott, Gaurav Chopra, Joshua E. Burda

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09887-yAfter spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological (...)

Nature