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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

mercredi 22 juillet 2026 par Lu Xue, Jiacheng Gui, Hainei Pan, Fan Wu, Shenghua Gao, Wenhua Kuang, Tiancai Chang, Zimu Li, Binqian Zou, Heyu Zhao, Mei Li, Min Zhou, Hongyu Yuan, Lijun Rong, Peng Gong, Jun He, Zengqin Deng, Manli Wang, Peng Zhan, Xinwen Chen, Xiaoli Xiong

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside (...)

Nature

CRISPR–Cas regulates expression of embedded anti-phage defence systems

mercredi 22 juillet 2026 par Xian Shu, Rui Wang, Xufei Zhou, Feiyue Cheng, Jiayue Ma, Zhihua Li, Xin Li, Tuozhan Wu, Aici Wu, Qiong Xue, Chao Liu, Huiwei Zhao, Xifeng Cao, Lin Wang, Shouyue Zhang, Yan Zhang, Ming Li

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial (...)

Nature

Non-epitaxial perovskite polariton laser diode operating under direct current

mercredi 22 juillet 2026 par Anatoly P. Pushkarev, Daria Khmelevskaia, Ivan A. Matchenya, Stepan A. Baryshev, Denis A. Sannikov, Alexey A. Ekgardt, Eduard I. Moiseev, Natalia V. Kryzhanovskaya, Alexey E. Zhukov, Dmitry V. Krasnikov, Alexandr A. Marunchenko, Alexey V. Yulin, Albert G. Nasibulin, Pavlos G. Lagoudakis

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10824-wBy integrating a solution-grown perovskite microplate with chemically inert single-walled carbon nanotube electrodes and embedding them into an optical microcavity, the new microdevices can achieve polariton lasing under a (...)

Nature

Prior therapy defines mutation profiles in childhood cancer at relapse

mercredi 22 juillet 2026 par Mehdi Layeghifard, Marcos Díaz-Gay, Erik N. Bergstrom, Mathepan J. Mahendralingam, Nicholas Light, Sasha Blay, Joshua O. Nash, Nathaniel D. Anderson, Jessica N. Au, Scott Davidson, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, S. M. Ashiqul Islam, Azhar Khandekar, Burçak Otlu, Ledia Brunga, Rawan Hammad, Shimaa Nassif, Nirav H. Thacker, Tara Feltham, Noemi A. Fuentes-Bolanos, Marie Wong-Erasmus, Max F. Levine, Katherine E. Miller, Neerav N. Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Sabrina Millson, Alexandra P. Zorzi, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew L. Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark J. Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, highlighting therapy-induced (...)

Nature

Structural basis of the RNA-editing cascade in trypanosome mitochondria

mercredi 22 juillet 2026 par Yun-Tao Liu, Andres F. Vacas, Jonathan Jih, Xiaojing Zhao, Clinton Yu, Jane K. J. Lee, Takuma Suematsu, Md Solayman, Hong Wang, Xiaorong Wang, Lan Huang, Liye Zhang, Inna Aphasizheva, Z. Hong Zhou, Ruslan Aphasizhev

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10831-xCryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine (...)

Nature

Insulator-free topological photonic multi-lane highways

mercredi 22 juillet 2026 par Xiaohan Cui, Ruo-Yang Zhang, Mudi Wang, Zi-Xuan Gao, Xiao-Dong Chen, Zhao-Qing Zhang, Yun Lai, C. T. Chan

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10817-9An insulator-free topological waveguide architecture comprising four inequivalent photonic valley half-semimetals arranged in a parallel, cyclic configuration and stacked very close to one another demonstrates robust, (...)

Nature

Planetary-mass exosatellite detected around the substellar companion of a star

mercredi 22 juillet 2026 par Kevin Hoy, Alice Zurlo, Pablo A Peña R, Jana Köhler, Silvano Desidera, Raffaele Gratton, Cecilia Lazzoni, Simon Petrus, Florian Rodler, Jonathan Smoker, Valentina D’Orazi, Ilaria Carleo, Ilaria Giovannini

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10751-wRadial velocity measurements provide evidence for a Jupiter-mass exosatellite orbiting the brown dwarf companion CD-35 2722 B, a promising detection of an exomoon-like (...)

Nature

A vector-based strategy for olfactory navigation in Drosophila

mercredi 22 juillet 2026 par Andrew F. Siliciano, Sun Minni, Chad Morton, Charles K. Dowell, Noelle B. Eghbali, Silas E. Busch, Juliana Y. Rhee, L. F. Abbott, Vanessa Ruta

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10827-7Using a virtual reality system, experiments in Drosophila show that flies use memory mechanisms to navigate along the boundary of an odour plume and track the source of a (...)

Nature

Precise DNA base editing using AlphaFold3-based contact modelling

mercredi 22 juillet 2026 par Haowei Meng, Zhixin Lei, Yongchang Yan, Liren Wang, Sihan Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang, Rongrong Liu, Gaohui Yang, Ruoyu Shen, Ruichu Gu, Xinyan Wang, Yiya Wang, Suiru Lu, Zhicong Lv, Bo He, Han Wen, Dali Li, Chengqi Yi

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10794-zContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

Nature

Tertiary lymphoid structures harbour stem-like tumour-specific T cells

mercredi 22 juillet 2026 par Alexander B. Afeyan, Adi Nagler, Chloe R. Tu, Gabriel Roberti De Oliveira, Berkay Simsek, Maxwell D. Seager, Nourhan El Ahmar, Haley E. Sax, Emma Lin, Amit Sud, Mehdi Borji, Cleo Forman, Sophia Liu, Patrick A. Ott, Toni K. Choueiri, Jennifer G. Abelin, Richard Burack, Shuqiang Li, Kenneth J. Livak, Svitlana Tyekucheva, Derin B. Keskin, Fei Chen, Michael B. Atkins, Jeremy M. Simon, Sabina Signoretti, Giacomo Oliveira, David A. Braun, Catherine J. Wu

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10808-wRenal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced terminal (...)

Nature