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Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells

mercredi 1er juillet 2026 par Neil Savage, Shan Grewal, Muhammad Vaseem Shaikh, Franz J. Zemp, Dillon Mckenna, Nicholas Mikolajewicz, Hinda Najem, Joanna Pyczek, Jiuran Wei, Mohamed A. B. Taleb, Lucas C. Asselstine, Alisha Anand, Shawn C. Chafe, Kui Zhai, William T. Maich, Chirayu R. Chokshi, Hardikkumar Patel, Tiegan E. Korman, Minomi Subapanditha, Zoya Tabunshchyk, Nazanin Tatari, Petar Miletic, David Chen, Sebastian Pacheco, Abdelsimar T. Omar, Bill Wang, Hong Han, Jennifer A. Chan, Kevin R. Brown, Chitra Venugopal, Thomas Kislinger, Amy B. Heimberger, Jason Moffat, Douglas J. Mahoney, Sheila K. Singh

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10641-1Integrated multi-omic profiling of glioblastoma reveals GPNMB as a shared antigen in tumour cells and the surrounding microenvironment, and GPNMB-targeted chimeric antigen receptor T cells demonstrate therapeutic activity in (...)

Nature

Tin perovskite transistors stabilized through volatile coordination

mercredi 1er juillet 2026 par Geonwoong Park, Dong Hyeon Lee, Youjin Reo, Wonryeol Yang, Soohwan Yoo, Wantae Park, Hyeyeon Jung, Hyesun Kim, Sungjae Cho, Mingoo Kwon, Sunmin Ryu, Liping Du, Ao Liu, Ji-Sang Park, Huihui Zhu, Yong-Young Noh

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10714-1A volatile-assisted coordination strategy regulates surface defect chemistry and self-doping, thus stabilizing the stoichiometry of tin perovskite semiconductors, resulting in transistors that can maintain stable operation (...)

Nature

Hadean bridgmanite in the source of a present-day ocean island

mercredi 1er juillet 2026 par Claudine Israel, Catherine Chauvel, Edward Inglis, Hui Chen, Cécile Hébert, James Badro

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10719-wNew high-precision neodymium isotope data measured on recently erupted lavas from the submarine Fani Maoré volcano in the Comoros archipelago allow the identification of heterogeneities dating back to Earth’s earliest (...)

Nature

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC

mercredi 1er juillet 2026 par Yiming Peng-Winkler, Xiao-Zheng Liu, Sanne M. L. Verheul, Charlotte Girondel, Sebastian Igelmann, Sara Marie Rotter, Michail Doukas, Ming Liu, Anke Vandekeere, Mélanie Planque, Juan Fernández-García, Sébastien Tabariès, Marta Buetas-Arcas, Sandra Martínez-Martín, Florian Döbbe, Margherita Demicco, Ines Vermeire, Janine Theile, Johannes Ceuppens, Jonas Haesevoets, Emma Tobarra-López, Dorien Broekaert, Johannes Georg Bode, Tom Luedde, Peter Vermeulen, Daniele V. F. Tauriello, Raquel Perez-Lopez, Steve Stegen, Laura Soucek, Tiago De Oliveira, Lena-Christin Conradi, Peter M. Siegel, Cornelis Verhoef, Sarah-Maria Fendt

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10686-2Liver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen (...)

Nature

Connecting single-cell transcriptomes to projectomes in the mouse visual cortex

mercredi 1er juillet 2026 par Staci A. Sorensen, Nathan W. Gouwens, Yun Wang, Matt Mallory, Agata Budzillo, Rachel Dalley, Brian R. Lee, Olga Gliko, Hsien-chi Kuo, Xiuli Kuang, Rusty Mann, Leila Ahmadinia, Lauren Alfiler, Fahimeh Baftizadeh, Katherine S. Baker, Sarah Bannick, Darren Bertagnolli, Kris Bickley, Phil Bohn, Jasmine Bomben, Chris Bowman, Gabriella Boyer, Krissy Brouner, Dillan Brown, Alex Cahoon, Natalie Chen, Chao Chen, Kai Chen, Maggie Chvilicek, Forrest Collman, Tanya L. Daigle, Tim Dawes, Rebecca de Frates, Nick Dee, Maxwell DePartee, Tom Egdorf, Laila El-Hifnawi, Rachel Enstrom, Luke Esposito, Colin Farrell, Rohan Gala, Clare Gamlin, Amanda Gary, Andrew Glomb, Olena Gerasymchuk, Jeff Goldy, Hong Gu, Kristen Hadley, Mike Hawrylycz, Alex Henry, Dijon Hill, Karla E. Hirokawa, Zili Huang, Katelyn Johnson, Zoe Juneau, Sara Kebede, Lisa Kim, Lauren Kruse, Changkyu Lee, Arielle L. Leon, Phil Lesnar, Quinn Lheureux, Anan Li, Yaoyao Li, Elizabeth Liang, Katie Link, Michelle Maxwell, Medea McGraw, Delissa A. McMillen, Alice Mukora, Lindsay Ng, Thomas Ochoa, Aaron Oldre, Daniel Park, Christina Alice Pom, Zoran Popovich, Lydia Potekhina, Ram Rajanbabu, Shea Ransford, Melissa R. Reding, Augustin Ruiz, David Sandman, Martin Schroedter, Josh Sevigny, Lyudmila Shulga, La’Akea Siverts, Cliff R. Slaughterbeck, Kimberly A. Smith, Michelle Stoecklin, Josef Sulc, Susan M. Sunkin, Michael Tieu, Jonathan T. Ting, Jessica Trinh, Ramel Velasco, Sara Vargas, Dave Vumbaco, Miranda Walker, Micheal Wang, Adrian Wanner, Jack Waters, Mirah Wells, Grace Williams, Julia A. Wilson, Wei Xiong, Ed S. Lein, Jim Berg, Brian E. Kalmbach, Shenqin Yao, Hui Gong, Qingming Luo, Quanxin Wang, Lydia Ng, Uygar Sümbül, Zizhen Yao, Tim Jarsky, Bosiljka Tasic, Hongkui Zeng

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10424-8In the mouse visual cortex, multimodal cell-type definitions, gene expression patterns and cell location predict long-range projection targets of excitatory neurons, linking transcriptomic identity with morphological, (...)

Nature

Targeted enzyme discovery using metal-coordination mining

mercredi 1er juillet 2026 par Ioannis Kipouros, Michelle C. Y. Chang

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10716-zA methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical (...)

Nature

Identification of cross-stage, cross-species malaria CD8⁺ T cell antigens

mercredi 1er juillet 2026 par Camila R. R. Barbosa, Luna B. de Lacerda, Paulo J. G. Bettencourt, David Morrow, Dhelio B. Pereira, Maya Aleshnick, Julie L. Mitchell, Nicholas C. Poulton, Cristopher Gomes, Lídia P. B. Cordeiro, Kadia Doumbia, Christina Ntalla, Charles Arama, Zezhou Zhao, Guilherme C. Maia, Gregório G. Almeida, Marie Rose Schrimpf, Thalia F. Hart, Derek Haumpy, Beatriz C. Medeiros-Rodrigues, Camila M. Costa, Annalisa Nicastri, Roxanne M. Gilbride, John B. Schell, Payton Kirtley, Lis R. V. Antonelli, Gaurav D. Gaiha, Scott G. Hansen, Judy Lieberman, Ricardo T. Gazzinelli, Moussa Niangaly, John Woodford, Joel Goldberg, Klaus Früh, Silvia Portugal, Patrick E. Duffy, Nicola Ternette, Brandon Wilder, Adrian V. S. Hill, Caroline Junqueira

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10730-1An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of the parasite’s life cycle, with possible applications in the (...)

Nature

A secreted endosymbiont protein essential for colonizing host cells

mercredi 1er juillet 2026 par Gerald P. Maeda, Allen Z. Xue, Ethan W. Yu, Aadhunik Sundar, Derrick L. Kamp, J. Elijah Powell, Thomas E. Smith, Nancy A. Moran

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10711-4SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera (...)

Nature

Replication-stress-induced chromatin loops protect fork stability

mercredi 1er juillet 2026 par Vincent Gaggioli, Kaustav Sengupta, Ashutosh Choudhury, Joanna Paulson, Raviprasad Kuthethur, Collin Bakker, Jialun Li, Calvin S. Y. Lo, Alex Whale, Jeroen van den Berg, Leire Asua Intxausti, Noelia Gil-Lanza, Iván Galván-Femenía, Eleni Maria Manolika, Sangavi Eswaran, Hina N. Khan, Estel Ferré, Gregorie Stik, Alexander van Oudenaarden, Argyris Papantonis, Jonathan Houseley, Sriram Sridharan, Arnab Ray Chaudhuri, Aleix Bayona-Feliu, Nitika Taneja

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10695-1Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

Nature

Isomeric multi-hydrogen-bonding enables blue perovskite LEDs

mercredi 1er juillet 2026 par Yuanzhi Wang, Chengxi Zhang, Yingguo Yang, Lingmei Kong, Bin Zhao, Zirui Liu, Pu Du, Dongyuan Han, Mengjia Cen, Lin Wang, Sheng Wang, Yanjun Liu, Lyudmila Turyanska, Andrew Bruhacs, Ning Wang, Xuyong Yang

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10723-0Hydrogen-bonding networks engineered with isomeric molecules enable stable, saturated blue perovskite LEDs with record external quantum efficiencies up to 22.0%, advancing high-performance full-colour display (...)

Nature