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Pervasive phosphorylation by phage T7 kinase disarms bacterial defences

mercredi 19 août 2026 par Tara Bartolec, Karin Mitosch, Clément Potel, Federico Corona, Alessio Ling Jie Yang, Nicolai Karcher, Mira Lea Burtscher, Alexandra Koumoutsi, Isabelle Becher, Lena Sarah Müller, Jacob Bobonis, Manjeet Kumar, Marco Galardini, Athanasios Typas, Mikhail M. Savitski

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10934-5The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.

Nature

A biased allosteric modulator is a molecular glue for ?₂AR dimerization

mercredi 19 août 2026 par Jiemin Shen, Teja Nikhil Peddada, Konstantin E. Komolov, Francesco De Pascali, Alexander M. Garces, Haoqing Wang, Muhammad Ehsan, Pil Seok Chae, Michael T. Lerch, Jeffrey L. Benovic, Jun Xu, Brian K. Kobilka

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10892-yAP-7-168, an optimized derivative of a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR), functions as a molecular glue to stabilize β2AR (...)

Nature

Virus deploys a ‘loose cannon’ enzyme to overpower bacterial defences

mercredi 19 août 2026

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02537-xViruses that infect bacteria must either evade or counter the defence systems of their host. The viral kinase enzyme T7K has been found to phosphorylate nearly all bacterial proteins, but its specificity for DNA-binding (...)

Nature

How do people live beyond 110? Abundance of cancer-killing cells might be key

mercredi 19 août 2026 par Katherine Bourzac

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02587-1Research on people 110 years and older reveals an immune system that continues to adapt.

Nature

Psychedelics tune the brain to the environment

mercredi 19 août 2026 par Stefan Borgwardt, Mihai Avram

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02377-9Rather than just scrambling neural activity, the psychedelic substance psilocybin also reorganizes brain dynamics so as to align with a person’s context and (...)

Nature

Rudolph A. Marcus obituary: theoretical chemist who explained how electrons jump between molecules

mercredi 19 août 2026 par Garnet Kin-Lic Chan, Kenneth H. Marcus

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02610-5His calculations explain the efficiency of batteries and solar cells.

Nature

AI tool lets researchers ‘vibe code’ in the quantum realm

mercredi 19 août 2026 par Davide Castelvecchi

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02495-4An autonomous AI agent can write and execute quantum computing code, but it sometimes needs a human touch.

Nature

Computational ‘gym’ trains AI models to control turbulence

mercredi 19 août 2026 par Clara M. Velte

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02375-xThe HydroGym computational environment teaches agents strategies for fluid-flow control that can be applied to scenarios they have not encountered before.

Nature

Human organoids that mimic brain development grown for years in lab

mercredi 19 août 2026 par Rachel Fieldhouse

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02585-3Models of how the brain changes over time could help researchers to understand how diseases affect the organ later in life.

Nature

Activity of solar-driven polymer catalysts unleashed to produce a potential green fuel

mercredi 19 août 2026 par Filip Podjaski

Nature, Published online: 19 August 2026; doi:10.1038/d41586-026-02373-zEngineering of polymer crystals has vastly increased the activity of these materials as catalysts for producing hydrogen fuel from water, using only sunlight.

Nature