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Developmental xenocortication using human-derived organoids in mice

mercredi 16 septembre 2026 par Konstantin Kaganovsky, Kevin W. Kelley, Tilo Gschwind, Paul M. Harary, John Kochalka, Alexander D. White, Garikoitz Lerma-Usabiaga, Xiaoyu Chen, Omer Revah, Felicity Gore, Ayano Aoyama, Jennifer L. Shadrach, Se-Jin Yoon, Alfredo Valencia, Satoe Ogawa, Noah Reis, Hannes Vogel, Brian Wandell, Julia A. Kaltschmidt, Ivan Soltesz, Karl Deisseroth, Sergiu P. Pa?ca

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Nature

Mitochondrial fission factor senses and governs ferroptosis

mercredi 16 septembre 2026 par Songjun Dai, Xiaoyan Dai, Tingting Zhang, Yuanyuan Qi, Xinquan Yang, Pengfei Diao, Chaodong Ge, Wenxiang Huang, Jisheng Ran, Xueliang Yang, Peng Zhang, Keke Zheng, Ruijun Wang, Hong Qian, Kunxiao Zhang, Junbing Wu, Caiyun Fu, Qian Ba, Junxia Min, Fudi Wang, Qiang Zhang

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-content screening of ferroptosis-sensitizing compounds and the (...)

Nature

Development of a random background to understand ligand optimization

mercredi 16 septembre 2026 par Xinyu Xu, Olivier Mailhot, Galen J. Correy, Xi-Ping Huang, Joao M. Braz, Da Shi, Karthik Srinivasan, Kara Zielinski, Yuliia Holota, Yuliia Kuziv, Christos Iliopoulos-Tsoutsouvas, Nathan D. Levinzon, Yagmur U. Doruk, Moira M. Rachman, Morgan E. Diolaiti, Maisie G. V. Stevens, Fangyu Liu, Katie L. Holland, Harald Hübner, Jing Wang, Yujin Wu, Alan Ashworth, Alexandros Makriyannis, Yuqi Zhang, Yurii S. Moroz, Peter Gmeiner, Robert Abel, Aashish Manglik, Allan I. Basbaum, Bryan L. Roth, James S. Fraser, Brian K. Shoichet

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Nature

Reimagining research papers as interactive and reliable AI agents

mercredi 16 septembre 2026 par Jiacheng Miao, Joe R. Davis, Yaohui Zhang, Jonathan K. Pritchard, James Zou

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11044-yPaper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based tool-invoking systems that reproduce original results, answer (...)

Nature

Electroluminescent photoresists extending lithographic scaling to OLEDs

mercredi 16 septembre 2026 par Shao-Wei Lo, Sunil B. Shivarudraiah, Zhan-Hong Lin, Patrick Helbling, Lifei Song, Jiachen Wang, Miguel Nouman, Fuze Jiang, Gerrit Stemmler, Donato Maria Carretta, Mei-Nung Chen, Jiayi Zhu, Sudhir Kumar, Hua Wang, Andrew J. Christofferson, Yinyin Bao, Chih-Jen Shih

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11042-0Electroluminescent photoresists synthesized via atom transfer radical polymerization can be directly patterned by ultraviolet and electron-beam lithography, and used to fabricate monolithic, multicolour (...)

Nature

Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus

mercredi 16 septembre 2026 par I. Morawetz, T. Riebner, L. Toscani De Col, F. Schneider, N. Sempelmann, F. Schaden, M. Bartokos, G. A. Kazakov, S. Lahs, K. Beeks, B. Gerstenecker, A. Grüneis, M. Pimon, T. Schumm, V. Lal, G. Zitzer, V. Petrov, J. Tiedau, M. V. Okhapkin, E. Peik

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much more efficient way to build a highly stable and robust solid-state optical (...)

Nature

Mutational constraints on RSV F and its neutralization by antibodies

mercredi 16 septembre 2026 par Cassandra A. L. Simonich, Teagan E. McMahon, Gavin Juviler, Lucas Kampman, Helen Y. Chu, Jesse D. Bloom

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, to show how Fab potency and epitope specificity combine to determine the effects (...)

Nature

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

mercredi 16 septembre 2026 par Pushpa Itagi, Samantha L. Schuster, Sonali Arora, Thomas W. Persse, Jennifer A. Waters, Michael Yang, Alan Min, Pooja Chandra, Mohamed Adil, Patricia C. Galipeau, Dmytro Rudoy, Allie S. Kreitman, Yixin Lin, Minjeong Ko, Erolcan Sayar, Robert D. Patton, Lori Kollath, Abby Meis, Samuel Lindergren, Nathan Ji, Khursheed Ali, Hrishi Venkatesh, Cynthia L. Wladyka, A. Patrick McDeed, Claire B. Mills, Manasvita Vashisth, Jin Yeong Kim, Rosa Nadal, Jessica E. Hawley, Todd A. Yezefski, Sarah P. Psutka, John L. Gore, Daniel W. Lin, Peter S. Nelson, Heather H. Cheng, Michael T. Schweizer, Lawrence Fong, John K. Lee, Evan Y. Yu, Eva Corey, Colm Morrissey, Petros Grivas, Robert B. Montgomery, Jonathan L. Wright, Michael C. Haffner, Funda Vakar-Lopez, Omar Y. Mian, Hung-Ming Lam, Andrew C. Hsieh, Gavin Ha

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-zA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastatic bladder (...)

Nature

Topographic structure and function of locus coeruleus noradrenaline neurons

mercredi 16 septembre 2026 par Zhixiao Su, Polina Kosillo, Kanghoon Jung, Shuonan Chen, Mathew T. Summers, Alex Piet, Han Hou, Kenta M. Hagihara, Drew Friedmann, Olivia Ho-Shing, Matthew I. Becker, Thomas Chartrand, Xinxin Yin, Peter Grotz, Ella Hilton-VanOsdall, Margaret Lee, Rajvi Javeri, Samantha L. Tuggle, Naveen Ouellette, Holly Myers, Judith Baka, Camilo Laiton, Kaelin Wulf, John Rohde, Alessio P. Buccino, Cameron Arshadi, Di Wang, Sharmishtaa Seshamani, Sonya Vasquez, Carolyn M. Eng, Douglas R. Ollerenshaw, Nick Dee, Tamara Casper, Windy Ho, Matthew Jungert, Atlas Jordan, Elliot Phillips, Anish Bhaswanth Chakka, Kamiliam Nasirova, Krista Blake, Audrey McCutcheon, Megan Koch, Maria Camila Vergara, Kimberly A. Smith, Tim Jarsky, Nicholas Lusk, Mara C. P. Rue, Xiaoyin Chen, Joshua H. Siegle, Adam K. Glaser, Brian R. Lee, Karel Svoboda, Yoh Isogai, Jayaram V. Chandrashekar, Jeremiah Y. Cohen

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard of reward-predictive (...)

Nature

Overmassive black holes and little red dots naturally form in simulations

mercredi 16 septembre 2026 par Sunmyon Chon, Shingo Hirano, Tomoaki Ishiyama, Seok-Jun Chang, Volker Springel

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10985-8Observations from the JWST reveal an unexpectedly abundant population of little red dots and overmassive black holes in the early Universe, which are confirmed by their formation in fully cosmological (...)

Nature