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Mazdutide versus placebo in Chinese adults with type 2 diabetes

mercredi 17 décembre 2025 par Dalong Zhu, Jiajun Zhao, Hanqing Cai, Xuan Chu, Shuangling Xiu, Chengwei Song, Zhifeng Cheng, Hongyi Cao, Hongwei Jiang, Lili Zhang, Haifang Wang, Bimin Shi, Yanbing Li, Ming Liu, Bo Feng, Fengtai Xue, Huan Deng, Haoyu Li, Li Li, Yue Li, Qingyang Ma, Lei Qian

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10026-wMazdutide versus placebo in Chinese adults with type 2 diabetes

Nature

How the Romans built their empire of concrete

mercredi 17 décembre 2025

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04080-7A unique archaeological site at Pompeii, Italy, reveals the secrets of peculiarly durable Roman building materials.

Nature

Biobanks reveal genetic complexity in human evolution

mercredi 17 décembre 2025

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-04079-0Tiny genetic variations between humans, Neanderthals and Denisovans might not be all they were cracked up to be.

Nature

Is bird flu the next pandemic? The science so far

mercredi 17 décembre 2025

Nature, Published online: 17 December 2025; doi:10.1038/d41586-025-03777-zKey mutations and animal spread could raise the risk to humans.

Nature

Transient hepatic reconstitution of trophic factors enhances aged immunity

mercredi 17 décembre 2025 par Mirco J. Friedrich, Julie Pham, Jiakun Tian, Hongyu Chen, Jiahao Huang, Niklas Kehl, Sophia Liu, Blake Lash, Fei Chen, Xiao Wang, Rhiannon K. Macrae, Feng Zhang

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09873-4Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.

Nature

Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis

mercredi 17 décembre 2025 par Sarajo K. Mohanta, Li Peng, Yuanfang Li, Shu Lu, Ting Sun, Lorenzo Carnevale, Marialuisa Perrotta, Zhe Ma, Benjamin Förstera, Karen Stanic, Chuankai Zhang, Xi Zhang, Piotr Szczepaniak, Mariaelvy Bianchini, Borhan R. Saeed, Raimondo Carnevale, Desheng Hu, Ryszard Nosalski, Fabio Pallante, Michael Beer, Donato Santovito, Ali Ertürk, Thomas C. Mettenleiter, Barbara G. Klupp, Remco T. A. Megens, Sabine Steffens, Jaroslav Pelisek, Hans-Henning Eckstein, Robert Kleemann, Livia Habenicht, Ziad Mallat, Jean-Baptiste Michel, Jürgen Bernhagen, Martin Dichgans, Giuseppe D’Agostino, Tomasz J. Guzik, Peder S. Olofsson, Changjun Yin, Christian Weber, Giuseppe Lembo, Daniela Carnevale, Andreas J. R. Habenicht

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-10043-9Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis

Nature

Gene-specific selective sweeps are pervasive across human gut microbiomes

mercredi 17 décembre 2025 par Richard Wolff, Nandita R. Garud

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09798-yDevelopment and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to meet (...)

Nature

GTP release-selective agonists prolong opioid analgesic efficacy

mercredi 17 décembre 2025 par Edward L. Stahl, Matthew A. Swanson, Vuong Q. Dang, Michael D. Cameron, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09880-5Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing (...)

Nature

Programmable 200 GOPS Hopfield-inspired photonic Ising machine

mercredi 17 décembre 2025 par Nayem Al-Kayed, Charles St-Arnault, Hugh Morison, A. Aadhi, Chaoran Huang, Alexander N. Tait, David V. Plant, Bhavin J. Shastri

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09838-7An architecture inspired by Hopfield networks based on a programmable, stable, room-temperature optoelectronic oscillator-based photonics Ising machine is introduced that can be used to efficiently address optimization (...)

Nature

An integrated view of the structure and function of the human 4D nucleome

mercredi 17 décembre 2025 par Job Dekker, Betul Akgol Oksuz, Yang Zhang, Ye Wang, Miriam K. Minsk, Shuzhen Kuang, Liyan Yang, Johan H. Gibcus, Nils Krietenstein, Oliver J. Rando, Jie Xu, Derek H. Janssens, Steven Henikoff, Alexander Kukalev, Willemin Andréa, Warren Winick-Ng, Rieke Kempfer, Ana Pombo, Miao Yu, Pradeep Kumar, Liguo Zhang, Andrew S. Belmont, Takayo Sasaki, Tom van Schaik, Laura Brueckner, Daan Peric-Hupkes, Bas van Steensel, Ping Wang, Haoxi Chai, Minji Kim, Yijun Ruan, Ran Zhang, Sofia A. Quinodoz, Prashant Bhat, Mitchell Guttman, Wenxin Zhao, Shu Chien, Yuan Liu, Sergey V. Venev, Dariusz Plewczynski, Ibai Irastorza Azcarate, Dominik Szabó, Christoph J. Thieme, Teresa Szczepi?ska, Mateusz Chili?ski, Kaustav Sengupta, Mattia Conte, Andrea Esposito, Alex Abraham, Ruochi Zhang, Yuchuan Wang, Xingzhao Wen, Qiuyang Wu, Yang Yang, Jie Liu, Lorenzo Boninsegna, Asli Yildirim, Yuxiang Zhan, Andrea Maria Chiariello, Simona Bianco, Lindsay Lee, Ming Hu, Yun Li, R. Jordan Barnett, Ashley L. Cook, Daniel J. Emerson, Claire Marchal, Peiyao Zhao, Peter J. Park, Burak H. Alver, Andrew J. Schroeder, Rahi Navelkar, Clara Bakker, William Ronchetti, Shannon Ehmsen, Alexander D. Veit, Nils Gehlenborg, Ting Wang, Daofeng Li, Xiaotao Wang, Mario Nicodemi, Bing Ren, Sheng Zhong, Jennifer E. Phillips-Cremins, David M. Gilbert, Katherine S. Pollard, Frank Alber, Jian Ma, William S. Noble, Feng Yue

Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09890-3The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of (...)

Nature