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Synthesizing scientific literature with retrieval-augmented language models

mercredi 4 février 2026 par Akari Asai, Jacqueline He, Rulin Shao, Weijia Shi, Amanpreet Singh, Joseph Chee Chang, Kyle Lo, Luca Soldaini, Sergey Feldman, Mike D’Arcy, David Wadden, Matt Latzke, Jenna Sparks, Jena D. Hwang, Varsha Kishore, Minyang Tian, Pan Ji, Shengyan Liu, Hao Tong, Bohao Wu, Yanyu Xiong, Luke Zettlemoyer, Graham Neubig, Daniel S. Weld, Doug Downey, Wen-tau Yih, Pang Wei Koh, Hannaneh Hajishirzi

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10072-4A specialized, open-source, retrieval-augmented language model is introduced for answering scientific queries and synthesizing literature, the responses of which are shown to be preferred by human evaluations over (...)

Nature

Signatures of fractional charges via anyon–trions in twisted MoTe₂

mercredi 4 février 2026 par Weijie Li, Christiano Wang Beach, Chaowei Hu, Takashi Taniguchi, Kenji Watanabe, Jiun-Haw Chu, Ataç Imamo?lu, Ting Cao, Di Xiao, Xiaodong Xu

Nature, Published online: 04 February 2026; doi:10.1038/s41586-026-10101-wFractionally charged excitations at zero magnetic field in twisted MoTe2 bilayers, a recently discovered fractional quantum anomalous Hall system, are observed via anyon-trions, excitonic complexes formed by binding a (...)

Nature

A pore-forming antiphage defence is activated by oligomeric phage proteins

mercredi 4 février 2026 par Pramalkumar H. Patel, Matthew R. McCarthy, Véronique L. Taylor, Gregory B. Cole, Chi Zhang, Matthew M. Edghill, Landon J. Getz, Beatrice C. M. Fung, Trevor F. Moraes, Alan R. Davidson, Michael J. Norris, Karen L. Maxwell

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10075-1Bacteria use diverse defence systems against phages, including a 164-residue prophage-encoded protein, Rip1, which senses conserved phage assembly rings to form membrane pores that block virion maturation and trigger (...)

Nature

Imaging a terahertz superfluid plasmon in a two-dimensional superconductor

mercredi 4 février 2026 par A. von Hoegen, T. Tai, C. J. Allington, M. Yeung, J. Pettine, M. H. Michael, E. Viñas Boström, X. Cui, K. Torres, A. E. Kossak, B. Lee, G. S. D. Beach, G. D. Gu, A. Rubio, P. Kim, N. Gedik

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10082-2Terahertz microspectroscopic imaging at subgap millielectronvolt energies of a two-dimensional superfluid plasmon in few-layer Bi2Sr2CaCu2O8+x is demonstrated, allowing the spatial resolution of its deeply subdiffractive (...)

Nature

Parkinson’s disease as a somato-cognitive action network disorder

mercredi 4 février 2026 par Jianxun Ren, Wei Zhang, Louisa Dahmani, Evan M. Gordon, Shenshen Li, Ying Zhou, Yang Long, Jianting Huang, Yafei Zhu, Ning Guo, Changqing Jiang, Feng Zhang, Yan Bai, Wei Wei, Yaping Wu, Alan Bush, Matteo Vissani, Luhua Wei, Carina R. Oehrn, Melanie A. Morrison, Ying Zhu, Chencheng Zhang, Qingyu Hu, Yilin Yin, Weigang Cui, Xiaoxuan Fu, Ping Zhang, Weiwei Wang, Gong-Jun Ji, Ji He, Kai Wang, Dongsheng Fan, Zhaoxia Wang, Teresa Kimberley, Simon Little, Philip A. Starr, Robert Mark Richardson, Luming Li, Meiyun Wang, Danhong Wang, Nico U. F. Dosenbach, Hesheng Liu

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10059-1The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor (...)

Nature

Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes

mercredi 4 février 2026 par Xueqing Zoe Zou, Fengyuan Hu, Haiyi Lou, Oliver S. Burren, Xiaoyin Li, Karyn Megy, Eleanor Wheeler, Qiang Wu, Santosh S. Atanur, Marcin Karpinski, Douglas Loesch, Zammy Fairhurst-Hunter, Sri V. V. Deevi, Erin Oerton, Sean Wen, Xiao Jiang, Cecilia Salvoro, Jonathan Mitchell, Abhishek Nag, Ben Hollis, Amanda O’Neill, Lauren Anderson-Dring, Mohammad Bohlooly-Y, Lisa Buvall, Sophia Cameron-Christie, Bram Prins, Suzanne Cohen, Regina F. Danielson, Andrew Davis, Wei Ding, Brian Dougherty, Manik Garg, Benjamin Georgi, Andrew Harper, Carolina Haefliger, Mårten Hammar, Richard N. Hanna, Ian Henry, Kousik Kundu, Zhongwu Lai, Mark Lal, Glenda Lassi, Yupu Liang, Margarida Lopes, Kieren Lythgow, Meeta Maisuria-Armer, Ruth March, Dorota Matelska, Rob Menzies, Erik Michaëlsson, Bill Mowrey, Daniel Muthas, Yoichiro Ohne, Benjamin Pullman, Sonja Hess, Arwa Raies, Anna Reznichenko, Xavier Romero Ros, Helen Stevens, Ioanna Tachmazidou, Coralie Viollet, Anna Walentinsson, Lily Wang, Qing-Dong Wang, Anna Cuomo, Daniel Elias Martin Herranz, Jared O’Connell, Jorge L. Del-Aguila, Anish Konkar, Benjamin Challis, Adam Platt, Tatiana Ort, James Garnett, Xiao-Rong Peng, Gabrielle Baumberg, Natalia Frydrych, Luca Stefanucci, Anna Szymaniak, Anna Maria Tsakiroglou, Rahul Sharma, Jen Harrow, Stewart MacArthur, Sebastian Wasilewski, Sean O’Dell, Lifeng Tian, Katherine R. Smith, Guillermo del Angel, Margarete Fabre, Ryan S. Dhindsa, Quanli Wang, Slavé Petrovski, Keren Carss

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10087-xA multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human (...)

Nature

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

mercredi 4 février 2026 par Haohan K. Wei, Chuyue D. Yu, Bo Hu, Xing Zeng, Hiroshi Ichise, Liang Li, Yu Wang, Ruiqi L. Wang, Ronald N. Germain, Rui B. Chang, Chengcheng Jin

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10028-8Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereby creating a immunologically (...)

Nature

Contemporaneous mobile- and stagnant-lid tectonics on the Hadean Earth

mercredi 4 février 2026 par John W. Valley, Tyler B. Blum, Kouki Kitajima, Kei Shimizu, Michael J. Spicuzza, Joseph P. Gonzalez, Noriko T. Kita, Ann M. Bauer, Stephan V. Sobolev, Charitra Jain, Aaron J. Cavosie, Alexander V. Sobolev

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10066-2Geochemical data from zircons show that subduction-like processes were operating contemporaneously with stagnant-lid-like processes at different locations as early as 4.4 billion years ago on the Hadean (...)

Nature

Single-molecule dynamics of the TRiC chaperonin system in vivo

mercredi 4 février 2026 par Rongqin Li, Niko Dalheimer, Martin B. D. Müller, F. Ulrich Hartl

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10073-3Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein (...)

Nature

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

mercredi 4 février 2026 par Siva Kumar Natarajan, Joanna Lum, James Haggerty Skeans, Minal Nenwani, Sanjana Eyunni, Mateus Mota, Jill M. Bayliss, Akash Deogharkar, Erin Taya Hamanishi, Matthew Pun, Stefan R. Sweha, Simon Hoffman, Eleanor Young, Qiuyang Zhang, Rijul Mehta, Olamide Animasahun, Pranav Narayanan, Sushanth Sunil, Abhijit Parolia, Peter Sajjakulnukit, Pooja Panwalkar, Robert Doherty, Madison Clausen, Derek Dang, Debra Hawes, Fusheng Yang, Mariarita Santi, Alexander R. Judkins, Yelena Wilson, Thomas Vigil, Andrea Franson, Richard M. Mortensen, Tatsuya Ozawa, Andrea Griesinger, Eric C. Holland, Nicholas K. Foreman, Kulandaimanuvel Antony Michealraj, Sameer Agnihotri, Michael Taylor, Richard J. Gilbertson, Carl Koschmann, Arul M. Chinnaiyan, Costas A. Lyssiotis, Deepak Nagrath, Sriram Venneti

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10005-1The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this (...)

Nature