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Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation

mercredi 4 février 2026 par Katarina Pfeifer, Devon Van Cura, Kelvin J. Y. Wu, Emily P. Balskus

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10079-xAn approach to discover reactive diazo-based metabolites by capture based on their reactivity coupled to mass spectrometry revealed two previously unknown diazo-containing compounds produced by the human lung pathogen (...)

Nature

Efficient near-telomere-to-telomere assembly of nanopore simplex reads

mercredi 4 février 2026 par Haoyu Cheng, Han Qu, Sean McKenzie, Katherine R. Lawrence, Rhydian Windsor, Mike Vella, Peter J. Park, Heng Li

Nature, Published online: 04 February 2026; doi:10.1038/s41586-026-10105-6A genome assembly method called hifiasm (ONT) allows the assembly of chromosomes from telomere to telomere without the need for ultra-long reads, and outperforms conventional methods on most evaluation (...)

Nature

Regulatory grammar in human promoters uncovered by MPRA-based deep learning

mercredi 4 février 2026 par Lucía Barbadilla-Martínez, Noud Klaassen, Vinícius H. Franceschini-Santos, Jérémie Breda, Hatice Yücel, Miguel Hernández-Quiles, Tijs van Lieshout, Carlos G. Urzua Traslaviña, Minh Chau Luong Boi, Maryam Akbarzadeh, Celia Hermana-Garcia-Agullo, Sebastian Gregoricchio, Marcel de Haas, Roy Straver, Sarah Derks, Wilbert Zwart, Emile Voest, Lude Franke, Michiel Vermeulen, Jeroen de Ridder, Bas van Steensel

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10093-zPARM is a deep-learning model trained on data from massively parallel reporter assays to help predict promoter activity in different human cell types, design synthetic promoters and identify key features of regulatory (...)

Nature

Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias

mercredi 4 février 2026 par Henrik Zetterberg, Barbara B. Bendlin

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10018-wImproved technologies facilitate the detection of molecules linked to neurodegenerative brain changes at very low concentrations in the blood, complementing the clinical evaluation of suspected neurodegenerative (...)

Nature

PtdIns(3,5)P₂ is an endogenous ligand of STING in innate immune signalling

mercredi 4 février 2026 par Jay Xiaojun Tan, Bo Lv, Jie Li, Tuo Li, Fenghe Du, Xiang Chen, Xuewu Zhang, Xiao-chen Bai, Zhijian J. Chen

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10084-0Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.

Nature

Atmospheric H₂ variability over the past 1,100 years

mercredi 4 février 2026 par John D. Patterson, Murat Aydin, Miranda H. Miranda, Eric S. Saltzman

Nature, Published online: 04 February 2026; doi:10.1038/s41586-026-10099-1Analysis of the atmospheric H2 variability over the past millennium suggests that the sensitivity of H2 to climate change should be considered in estimates of the radiative consequences of rising anthropogenic H2 (...)

Nature

Large-scale analogue quantum simulation using atom dot arrays

mercredi 4 février 2026 par M. B. Donnelly, Y. Chung, R. Garreis, S. Plugge, D. Pye, M. Kiczynski, J. Támara-Isaza, M. M. Munia, S. Sutherland, B. Voisin, L. Kranz, Y. L. Hsueh, A. M. Saffat-Ee Huq, C. R. Myers, R. Rahman, J. G. Keizer, S. K. Gorman, M. Y. Simmons

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10053-7A new platform comprising large-scale 2D arrays of quantum dots patterned with sub-nanometre precision, with each quantum dot defined by tens of phosphorus atoms doped into silicon, allows for analogue simulation of (...)

Nature

Discovery Learning predicts battery cycle life from minimal experiments

mercredi 4 février 2026 par Jiawei Zhang, Yifei Zhang, Baozhao Yi, Yao Ren, Qi Jiao, Hanyu Bai, Weiran Jiang, Ziyou Song

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-09951-7Discovery Learning, a machine learning approach integrating active learning, physics-guided learning and zero-shot learning into a human-like reasoning loop, is described for predicting the battery cycle life of new (...)

Nature

Bacterial immune activation via supramolecular assembly with phage triggers

mercredi 4 février 2026 par Tong Zhang, Yifei Lyu, Christina R. Beck, Naseer Iqbal, Renee Barbosa, Alireza Ghanbarpour, Michael T. Laub

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10060-8An antiphage defence system has an activation mechanism that relies on the sensing of phage-encoded proteins that enforce geometry crucial to activation and are not typically present in non-infected (...)

Nature

Measuring spin correlation between quarks during QCD confinement

mercredi 4 février 2026 par B. E. Aboona, J. Adam, L. Adamczyk, I. Aggarwal, M. M. Aggarwal, Z. Ahammed, A. K. Alshammri, E. C. Aschenauer, S. Aslam, J. Atchison, V. Bairathi, X. Bao, P. Barik, K. Barish, S. Behera, R. Bellwied, P. Bhagat, A. Bhasin, S. Bhatta, S. R. Bhosale, J. Bielcik, J. Bielcikova, J. D. Brandenburg, C. Broodo, X. Z. Cai, H. Caines, M. Calderó, D. Cebra, J. Ceska, I. Chakaberia, P. Chaloupka, Y. S. Chang, Z. Chang, A. Chatterjee, D. Chen, J. H. Chen, Q. Chen, W. Chen, Z. Chen, J. Cheng, Y. Cheng, W. Christie, X. Chu, S. Corey, H. J. Crawford, M. Csanád, G. Dale-Gau, A. Das, D. De Souza Lemos, I. M. Deppner, A. Deshpande, A. Dhamija, A. Dimri, P. Dixit, X. Dong, J. L. Drachenberg, E. Duckworth, J. C. Dunlop, Y. S. El-Feky, J. Engelage, G. Eppley, S. Esumi, O. Evdokimov, O. Eyser, B. Fan, R. Fatemi, S. Fazio, H. Feng, Y. Feng, E. Finch, Y. Fisyak, F. A. Flor, C. Fu, T. Fu, C. A. Gagliardi, T. Galatyuk, T. Gao, Y. Gao, G. Garcia, F. Geurts, A. Gibson, A. Giri, K. Gopal, X. Gou, D. Grosnick, A. Gu, J. Gu, A. Gupta, W. Guryn, A. Hamed, R. J. Hamilton, J. Han, X. Han, S. Harabasz, M. D. Harasty, J. W. Harris, H. Harrison-Smith, L. B. Havener, X. H. He, Y. He, N. Herrmann, L. Holub, C. Hu, Q. Hu, Y. Hu, H. Huang, H. Z. Huang, S. L. Huang, T. Huang, Y. Huang, M. Isshiki, W. W. Jacobs, A. Jalotra, C. Jena, A. Jentsch, Y. Ji, J. Jia, X. Jiang, C. Jin, Y. Jin, N. Jindal, X. Ju, E. G. Judd, S. Kabana, D. Kalinkin, J. Kang, K. Kang, A. R. Kanuganti, D. Kapukchyan, K. Kauder, D. Keane, M. Kesler, A. Khanal, Y. V. Khyzhniak, D. P. Kiko?a, J. Kim, D. Kincses, I. Kisel, A. Kiselev, A. G. Knospe, J. Ko?a?, B. Korodi, L. K. Kosarzewski, L. Kumar, M. C. Labonte, R. Lacey, J. M. Landgraf, C. Larson, J. Lauret, A. Lebedev, J. H. Lee, Y. H. Leung, C. Li, D. Li, H-S. Li, H. Li, W. Li, X. Li, Y. Li, Z. Li, X. Liang, R. Licenik, T. Lin, Y. Lin, M. A. Lisa, C. Liu, G. Liu, H. Liu, L. Liu, Z. Liu, T. Ljubicic, O. Lomicky, E. M. Loyd, T. Lu, J. Luo, X. F. Luo, L. Ma, R. Ma, Y. G. Ma, N. Magdy, D. Mallick, R. Manikandhan, C. Markert, O. Matonoha, K. Mi, S. Mioduszewski, B. Mohanty, B. Mondal, M. M. Mondal, I. Mooney, J. Mrazkova, M. I. Nagy, C. J. Naim, A. S. Nain, J. D. Nam, M. Nasim, H. Nasrulloh, J. M. Nelson, M. Nie, G. Nigmatkulov, T. Niida, T. Nonaka, G. Odyniec, A. Ogawa, S. Oh, K. Okubo, B. S. Page, S. Pal, A. Pandav, A. Panday, A. K. Pandey, T. Pani, A. Paul, S. Paul, D. Pawlowska, C. Perkins, S. Ping, J. Pluta, B. R. Pokhrel, I. D. Ponce Pinto, M. Posik, E. Pottebaum, S. Prodhan, T. L. Protzman, A. Prozorov, V. Prozorova, N. K. Pruthi, M. Przybycien, J. Putschke, Y. Qi, Z. Qin, H. Qiu, C. Racz, S. K. Radhakrishnan, A. Rana, R. L. Ray, R. Reed, C. W. Robertson, M. Robotkova, M. A. Rosales Aguilar, D. Roy, P. Roy Chowdhury, L. Ruan, A. K. Sahoo, N. R. Sahoo, H. Sako, S. Salur, S. S. Sambyal, J. K. Sandhu, S. Sato, B. C. Schaefer, N. Schmitz, F-J. Seck, J. Seger, R. Seto, P. Seyboth, N. Shah, P. V. Shanmuganathan, T. Shao, M. Sharma, N. Sharma, R. Sharma, S. R. Sharma, A. I. Sheikh, D. Shen, D. Y. Shen, K. Shen, S. Shi, Y. Shi, E. Shulga, F. Si, J. Singh, S. Singha, P. Sinha, M. J. Skoby, N. Smirnov, Y. Söhngen, Y. Song, T. D. S. Stanislaus, M. Stefaniak, Y. Su, M. Sumbera, X. Sun, Y. Sun, B. Surrow, M. Svoboda, Z. W. Sweger, A. C. Tamis, A. H. Tang, Z. Tang, T. Tarnowsky, J. H. Thomas, A. R. Timmins, D. Tlusty, D. Torres Valladares, S. Trentalange, P. Tribedy, S. K. Tripathy, T. Truhlar, B. A. Trzeciak, O. D. Tsai, C. Y. Tsang, Z. Tu, J. E. Tyler, T. Ullrich, D. G. Underwood, G. Van Buren, J. Vanek, I. Vassiliev, F. Videbæk, S. A. Voloshin, F. Wang, G. Wang, J. S. Wang, J. Wang, K. Wang, X. Wang, Y. Wang, Z. Wang, Z. Y. Wang, A. J. Watroba, J. C. Webb, P. C. Weidenkaff, G. D. Westfall, D. Wielanek, H. Wieman, G. Wilks, S. W. Wissink, R. Witt, C. P. Wong, J. Wu, X. Wu, B. Xi, Y. Xiao, Z. G. Xiao, G. Xie, W. Xie, H. Xu, N. Xu, Q. H. Xu, Y. Xu, Z. Xu, G. Yan, Z. Yan, C. Yang, Q. Yang, S. Yang, Y. Yang, Z. Ye, L. Yi, Y. Yu, H. Zbroszczyk, W. Zha, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, W. Zhang, X. Zhang, Y. Zhang, Z. Zhang, F. Zhao, J. Zhao, S. Zhou, Y. Zhou, X. Zhu, M. Zurek, M. Zyzak

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-09920-0The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in $$\Lambda \bar\Lambda $$ Λ Λ ¯ hyperon pairs inherited from virtual spin-correlated (...)

Nature