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Spatial joint profiling of DNA methylome and transcriptome in tissues

mercredi 3 septembre 2025 par Chin Nien Lee, Hongxiang Fu, Angelysia Cardilla, Wanding Zhou, Yanxiang Deng

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09478-xDNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription interact to shape cell identity and (...)

Nature

A circuit that integrates drive state and social contact to gate mating

mercredi 3 septembre 2025 par Lindsey D. Salay, Doris Y. Tsao, David J. Anderson

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09327-xAnalyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive (...)

Nature

Single-cell transcriptomic and genomic changes in the ageing human brain

mercredi 3 septembre 2025 par Ailsa M. Jeffries, Tianxiong Yu, Jennifer S. Ziegenfuss, Allie K. Tolles, Christina E. Baer, Cesar Bautista Sotelo, Yerin Kim, Zhiping Weng, Michael A. Lodato

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09435-8Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the (...)

Nature

Divergent evolutionary strategies pre-empt tissue collision in gastrulation

mercredi 3 septembre 2025 par Bipasha Dey, Verena Kaul, Girish Kale, Maily Scorcelletti, Michiko Takeda, Yu-Chiun Wang, Steffen Lemke

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09447-4Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit (...)

Nature

Brain-wide representations of prior information in mouse decision-making

mercredi 3 septembre 2025 par Charles Findling, Felix Hubert, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, E. Kelly Buchanan, Sebastian Bruijns, Matteo Carandini, Joana A. Catarino, Gaelle A. Chapuis, Anne K. Churchland, Yang Dan, Felicia Davatolhagh, Eric E. J. DeWitt, Tatiana A. Engel, Michele Fabbri, Mayo A. Faulkner, Ila Rani Fiete, Laura Freitas-Silva, Berk Gerçek, Kenneth D. Harris, Michael Häusser, Sonja B. Hofer, Fei Hu, Julia M. Huntenburg, Anup Khanal, Chris Krasniak, Christopher Langdon, Christopher A. Langfield, Peter E. Latham, Petrina Y. P. Lau, Zach Mainen, Guido T. Meijer, Nathaniel J. Miska, Thomas D. Mrsic-Flogel, Jean-Paul Noel, Kai Nylund, Alejandro Pan-Vazquez, Liam Paninski, Jonathan Pillow, Cyrille Rossant, Noam Roth, Rylan Schaeffer, Michael Schartner, Yanliang Shi, Karolina Z. Socha, Nicholas A. Steinmetz, Karel Svoboda, Charline Tessereau, Anne E. Urai, Miles J. Wells, Steven Jon West, Matthew R. Whiteway, Olivier Winter, Ilana B. Witten, Anthony Zador, Yizi Zhang, Peter Dayan, Alexandre Pouget

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09226-1Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Nature

Analog optical computer for AI inference and combinatorial optimization

mercredi 3 septembre 2025 par Kirill P. Kalinin, Jannes Gladrow, Jiaqi Chu, James H. Clegg, Daniel Cletheroe, Douglas J. Kelly, Babak Rahmani, Grace Brennan, Burcu Canakci, Fabian Falck, Michael Hansen, Jim Kleewein, Heiner Kremer, Greg O’Shea, Lucinda Pickup, Saravan Rajmohan, Ant Rowstron, Victor Ruhle, Lee Braine, Shrirang Khedekar, Natalia G. Berloff, Christos Gkantsidis, Francesca Parmigiani, Hitesh Ballani

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09430-zAn analog optical computer that combines analog electronics, three-dimensional optics, and an iterative architecture accelerates artificial intelligence inference and combinatorial optimization in a single platform, (...)

Nature

A brain-wide map of neural activity during complex behaviour

mercredi 3 septembre 2025 par Leenoy Meshulam, Dora Angelaki, Julius Benson, Isaiah McRoberts, Jean-Paul Noel, Jaime Arlandis, Niccolò Bonacchi, Kcenia Bougrova, Joana A. Catarino, Fanny Cazettes, Davide Crombie, Eric EJ DeWitt, Laura Freitas-Silva, Inês C. Laranjeira, Zachary F. Mainen, Guido T. Meijer, Pranav Rai, Georg Raiser, Florian Rau, Michael M. Schartner, Olivier Winter, Anne E. Urai, Valeria Aguillon-Rodriguez, Cristian Soitu, Anthony M. Zador, Christopher S. Krasniak, Yang Dan, Fei Hu, Brandon Benson, Surya Ganguli, Luigi Acerbi, Gaelle A. Chapuis, Charles Findling, Berk Gercek, Felix Huber, Alexandre Pouget, Hailey Barrell, Dan Birman, Kim Miller, Kai Nylund, Noam Roth, Nicholas A. Steinmetz, Matthew Tucker, Kenneth Yang, Ila Rani Fiete, Ari Liu, Rylan Schaeffer, Anne K. Churchland, Felicia Davatolhagh, Anup Khanal, Maxwell Melin, Masayoshi Murakami, Sophie Denève, Ivan Gordeliy, Mandana Ahmadi, Jaweria Amjad, Naoki Hiratani, Sanjukta Krishnagopal, Peter Latham, Alberto Pezzotta, Zekai Xu, Kush Banga, Jai Bhagat, Mayo Faulkner, Kenneth D. Harris, Michael Krumin, Samuel Picard, Carolina Quadrado, Cyrille Rossant, Miles J. Wells, Lauren E. Wool, Matteo Carandini, Agnès Landemard, Karolina Z. Socha, Sebastian A. Bruijns, Peter Dayan, Julia M. Huntenburg, Debottam Kundu, Farideh Oloomi, Charline Tessereau, Zoe C. Ashwood, Tatiana Engel, Robert Fetcho, Laura M. Haetzel, Christopher Langdon, Brenna McMannon, Zeinab Mohammadi, Alejandro Pan Vazquez, Jonathan W. Pillow, Nicholas A. Roy, Yanliang Shi, Ilana B. Witten, Robert Campbell, Naureen Ghani, Sonja B. Hofer, Hernando Martinez-Vergara, Nathaniel J. Miska, Thomas Mrsic-Flogel, Steven J. West, Yaxuan Yang, Karel Svoboda, Marsa Taheri, Michael Häusser, Petrina Y. P. Lau, Amalia Makri-Cottington, Sabrina Perrenoud, Larry Abbot, Hannah M. Bayer, Julien Boussard, E. Kelly Buchanan, Michele Fabbri, Cole Hurwitz, Christopher Langfield, Hyun Dong Lee, Catalin Mitelut, Liam Paninski, Kamron Saniee, Erdem Varol, Shuqi Wang, Matthew R. Whiteway, Charles Windolf, Han Yu, Yizi Zhang, Daniel Birman, Kcénia Bougrova, Tatiana A. Engel, Berk Gerçek, Félix Hubert, Thomas D. Mrsic-Flogel, Alejandro Pan-Vazquez, Michael Schartner

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09235-0The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in (...)

Nature

A prudent planetary limit for geologic carbon storage

mercredi 3 septembre 2025 par Matthew J. Gidden, Siddharth Joshi, John J. Armitage, Alina-Berenice Christ, Miranda Boettcher, Elina Brutschin, Alexandre C. Köberle, Keywan Riahi, Hans Joachim Schellnhuber, Carl-Friedrich Schleussner, Joeri Rogelj

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09423-yA risk-based, spatially explicit analysis of carbon storage in sedimentary basins establishes a prudent planetary limit of around 1,460 Gt of geological carbon storage, which requires making explicit decisions on (...)

Nature

An Evolutionary 'Big Bang' Explains Why Snakes Come in So Many Strange Varieties

vendredi 23 février 2024 par Jack Tamisiea — Biology, Animals, Evolution

Snakes saw a burst of adaptation about 128 million years ago that led to them exploding in diversity and evolving up to three times faster than lizards

Scientific American