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Dynamic fibroblast–immune interactions shape recovery after brain injury

mercredi 3 septembre 2025 par Nathan A. Ewing-Crystal, Nicholas M. Mroz, Amara Larpthaveesarp, Carlos O. Lizama, Remy Pennington, Pailin Chiaranunt, Jason I. Dennis, Anthony A. Chang, Eric Dean Merrill, Sofia E. Caryotakis, Nikhita Kirthivasan, Leon Teo, Tatsuya Tsukui, Aditya Katewa, Gabriel L. McKinsey, Sophia C. K. Nelson, Agnieszka Ciesielska, Nicole C. Lummis, Lucija Pintari?, Madelene W. Dahlgren, Amha Atakilit, Helena Paidassi, Saket Jain, Xiaodan Liu, Duan Xu, Manish K. Aghi, James A. Bourne, Jeanne T. Paz, Richard Daneman, Fernando F. Gonzalez, Dean Sheppard, Anna V. Molofsky, Thomas D. Arnold, Ari B. Molofsky

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09449-2Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and (...)

Nature

One mother for two species via obligate cross-species cloning in ants

mercredi 3 septembre 2025 par Y. Juvé, C. Lutrat, A. Ha, A. Weyna, E. Lauroua, A. C. Afonso Silva, C. Roux, E. Schifani, C. Galkowski, C. Lebas, R. Allio, I. Stoyanov, N. Galtier, B. C. Schlick-Steiner, F. M. Steiner, D. Baas, B. Kaufmann, J. Romiguier

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09425-wIn a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct (...)

Nature

Multiple overlapping binding sites determine transcription factor occupancy

mercredi 3 septembre 2025 par Shubham Khetan, Brent S. Carroll, Martha L. Bulyk

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09472-3A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create overlapping (...)

Nature

Infrastructure deficits and informal settlements in sub-Saharan Africa

mercredi 3 septembre 2025 par Luís M. A. Bettencourt, Nicholas Marchio

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09465-2A new network approach maps every street block in sub-Saharan Africa using high-resolution building and street data, pinpointing infrastructure needs and revealing development gradients from neighbourhoods to cities and (...)

Nature

Amygdala–liver signalling orchestrates glycaemic responses to stress

mercredi 3 septembre 2025 par J. R. E. Carty, K. Devarakonda, R. M. O’Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R. F. Hampton, R. Li, Y. Qiu, S. Petri, A. Shtekler, A. Rajbhandari, K. Conner, M. Bayne, D. Garibay, J. Martin, V. Lehmann, L. Wang, K. Beaumont, I. Kurland, G. C. Yuan, P. J. Kenny, S. A. Stanley

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09420-1Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independently of adrenal and (...)

Nature

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target

mercredi 3 septembre 2025 par Sanna N. Masud, Anchal Srivastava, Patricia Mero, Victoria Saba Echezarreta, Eve Anderson, Lennard van Buren, Jiarun Wei, David Thomson Taylor, Adrian Granda Farias, Nicholas Mikolajewicz, Angela Shaw, Brandon M. Murareanu, Michelle Lohbihler, Olivia Sniezek Carney, Simon van Heeringen, Linda Clijsters, Olga Sizova, Jeroen van Ameijde, Freya Nye, Andrea Habsid, Lucy Nedyalkova, Laura McDonald, Craig Simpson, Leanne Wybenga-Groot, Kevin R. Brown, Nhi Nho, Radu M. Suciu, Katherine Chan, Amy H. Y. Tong, Frédéric M. Vaz, Bastiaan Evers, Robert Lesurf, Tanya Papaz, Lauryl M. J. Nutter, Stephanie Protze, Maximilian Billmann, Michael Costanzo, Brenda J. Andrews, Chad L. Myers, Seema Mital, Hilary Vernon, Thijn R. Brummelkamp, Charles Boone, Ian C. Scott, Micah J. Niphakis, Douglas Strathdee, Sebastian M. B. Nijman, Vincent A. Blomen, Jason Moffat

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09373-5The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth (...)

Nature

DNA2 enables growth by restricting recombination-restarted replication

mercredi 3 septembre 2025 par Jessica J. R. Hudson, Rowin Appanah, David Jones, Kathryn Davidson, Alice M. Budden, Alina Vaitsiankova, Kok-Lung Chan, Keith W. Caldecott, Antony M. Carr, Ulrich Rass

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09470-5DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, highlighting its (...)

Nature

Latent resistance mechanisms of steel truss bridges after critical failures

mercredi 3 septembre 2025 par Juan C. Reyes-Suárez, Manuel Buitrago, Brais Barros, Safae Mammeri, Nirvan Makoond, Carlos Lázaro, Belén Riveiro, Jose M. Adam

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09300-8Experimental tests and computational simulations of a scaled-down specimen of a real steel truss bridge identify and characterize the latent resistance mechanisms following critical failures, demonstrating how loads (...)

Nature

'How is this possible?' — two species birthed by one mother

mercredi 3 septembre 2025 par Nick Petri? Howe

Nature, Published online: 03 September 2025; doi:10.1038/d41586-025-02834-xTwo brother ants defy species borders, by sharing the same mother despite being genetically different species.

Nature