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Fasting boosts breast cancer therapy efficacy via glucocorticoid activation

mercredi 10 décembre 2025 par Nuno Padrão, Tesa M. Severson, Sebastian Gregoricchio, Ana Guijarro, Catrin Lutz, Daniel Taranto, Stefan Hutten, Francesca Ligorio, Angelica Persia, Merel Roest, Joyce Sanders, Ji-Ying Song, Sara Pires-Oliveira, Maria Donaldson Collier, Hugo Horlings, Livia Pisciotta, Filippo de Braud, Claudio Vernieri, Leila Akkari, Jos Jonkers, Alessio Nencioni, Irene Caffa, Wilbert Zwart

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09869-0Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting to reduce harmful (...)

Nature

Neanderthals mastered fire — 400,000 years ago

mercredi 10 décembre 2025 par Nick Petri? Howe, Anne Marie Conlon

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-04059-4Archaeological evidence makes a compelling case for Neanderthal-created fires 400,000 years ago in Suffolk, UK — plus, how chatbots can sway the opinions of (...)

Nature

Exposing a silent cancer

mercredi 10 décembre 2025 par Rachel Nuwer

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03942-4Pancreatic cancer is one of the deadliest malignancies, and it is increasingly occurring in young people — especially women. An uptick in research funding is a welcome development in the push to transform (...)

Nature

Will young universities set the pace in the age of AI?

mercredi 10 décembre 2025 par Bec Crew

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03949-xWhy some institutions are betting on technology to stay relevant.

Nature

Glimmers of hope for a deadly disease

mercredi 10 décembre 2025 par Shraddha Chakradhar

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03941-5New models, efforts for early detection and better therapies may help change pancreatic cancer’s aggressive course.

Nature

China is leading the world on AI governance: other countries must engage

mercredi 10 décembre 2025

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03972-yThe nation’s regulators are attempting to match the rapid pace at which AI is evolving. That needs to become a global initiative.

Nature

Is your brain tired? Researchers are discovering the roots of mental fatigue

mercredi 10 décembre 2025 par Lynne Peeples

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03974-wBetter ways to measure cognitive exhaustion could point to treatments for long COVID and other debilitating disorders.

Nature

Hot droughts in the Amazon provide a window to a future hypertropical climate

mercredi 10 décembre 2025 par Jeffrey Q. Chambers, Adriano José Nogueira Lima, Gilberto Pastorello, Bruno Oliva Gimenez, Lin Meng, Lee A. Dyer, Yanlei Feng, Cristina Santos da Silva, Regison Costa de Oliveira, Anna Weber, Charlie Koven, Robinson Negrón-Juárez, Gustavo C. Spanner, Tatiana D. Gaui, Clarissa G. Fontes, Alessandro C. de Araújo, Nate McDowell, Ruby Leung, Daniel Magnabosco Marra, Jeffrey Warren, Daisy Celestina Souza, Cynthia Wright, Kolby Jardine, Marcos Longo, Chonggang Xu, Paul V. A. Fine, Rosie A. Fisher, Javier Tomasella, Joaquim dos Santos, Niro Higuchi

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09728-yThirty years of forest demographic data, combined with recent ecophysiological measurements, reveal that intense Amazon droughts sharply increase tree mortality once soil moisture falls below a threshold, and that these (...)

Nature

A direct role for a mitochondrial targeting sequence in signalling stress

mercredi 10 décembre 2025 par Zixuan Yuan, Megan Balzarini, Marina Volpe, Madeleine Goldstein, Tony Shengzhe Peng, Elizabeth Hui, Nancy Neng Fang, Waleed S. Albihlal, Melika Hajimohammadi, Kevin Wei, Calvin K. Yip, Folkert J. van Werven, Thibault Mayor, Hilla Weidberg

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09834-xCells can sense mitochondrial damage through signalling via an unimported mitochondrial targeting sequence.

Nature

Neutrophils preserve energy storage in sympathetically activated adipocytes

mercredi 10 décembre 2025 par Seunghwan Son, Cindy Xu, Haipeng Fu, Churaibhon Wisessaowapak, Joseph M. Valentine, Garam An, Janice Jang, Maddox Dinh, Yang Dai, Weiwei Fan, Ruth T. Yu, Michael Downes, Wei Ying, Yuliya Skorobogatko, Ronald M. Evans, Alan R. Saltiel

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09839-6Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.

Nature