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Controlling pyramidal nitrogen chirality by asymmetric organocatalysis

mercredi 12 novembre 2025 par San Wu, Pengquan Chen, Meng Duan, Peng-Ying Jiang, Qingyang Zhou, Shao-Hua Xiang, K. N. Houk, Bin Tan

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09607-6An asymmetric organocatalysis strategy is used to control pyramidal nitrogen chirality and to synthesize the enantioselective N-chloroaziridines with a configurationally stable nitrogen stereogenic (...)

Nature

In situ structural mechanism of epothilone-B-induced CNS axon regeneration

mercredi 12 novembre 2025 par Satish Bodakuntla, Kenichiro Taira, Yurika Yamada, Pelayo Alvarez-Brecht, A. King Cada, Nirakar Basnet, Rui Zhang, Antonio Martinez-Sanchez, Christian Biertümpfel, Naoko Mizuno

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09654-zA combined cryo-electron tomography and cryo-electron microscopy pipeline was developed to inflict axonal damage and monitor the cellular response induced by epothilone B, revealing that microtubule polymerization at and (...)

Nature

Ecology and spread of the North American H5N1 epizootic

mercredi 12 novembre 2025 par Lambodhar Damodaran, Anna S. Jaeger, Louise H. Moncla

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09737-xThe panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primarily (...)

Nature

Estimation and mapping of the missing heritability of human phenotypes

mercredi 12 novembre 2025 par Pierrick Wainschtein, Yuanxiang Zhang, Jeremy Schwartzentruber, Irfahan Kassam, Julia Sidorenko, Petko P. Fiziev, Huanwei Wang, Jeremy McRae, Richard Border, Noah Zaitlen, Sriram Sankararaman, Michael E. Goddard, Jian Zeng, Peter M. Visscher, Kyle Kai-How Farh, Loic Yengo

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09720-6WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 complex traits and (...)

Nature

Spatial fibroblast niches define Crohn’s fistulae

mercredi 12 novembre 2025 par Colleen McGregor, Xiao Qin, Marta Jagielowicz, Tarun Gupta, Zinan Yin, Verena Lentsch, David Fawkner-Corbett, Vy Wien Lai, Paula Gomez Castro, Esther Bridges, Chloe Hyun-Jung Lee, Huei-Wen Chuang, Lei Deng, Anna Aulicino, Renuka Teague, Sorayya Moradi, Jun Sung Park, Jeongmin Woo, Kexin Xu, Ruchi Tandon, Nicole Cianci, Jan Bornschein, Ling-Pei Ho, Paulina Siejka-Zielinska, Zoe Christoforidou, Sarah Hill, Johannes Lehmann, Rhea Kujawa, Paola Vargas Gutierrez, Carol Cheng, Maria Greco, Katherine Baker, Mark Bignell, Bruce George, Eve Fryer, Michael Vieth, Agne Antanaviciute, Alison Simmons

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09744-ySpatial transcriptomic analysis of cells in intestinal fistulae of patients with Crohn’s disease reveals the existence of specialized fistula-associated cell states with distinct signalling profiles and extracellular (...)

Nature

Florigen activation complex forms via multifaceted assembly in Arabidopsis

mercredi 12 novembre 2025 par He Gao, Na Ding, Yuang Wu, Dongli Yu, Shi-Zhao Zhou, Sara Christina Stolze, Coral Vincent, Gabriel Rodríguez Maroto, Pedro de los Reyes, Anne Harzen, Martina Cerise, Vítor da Silveira Falavigna, Ertong Li, Ton Timmers, Ulla Neumann, Hirofumi Nakagami, Jin-Yong Hu, Jijie Chai, George Coupland

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09704-6In flowering plants, DNA–FD–14-3-3 recruits FT to the florigen activation complex both through DNA–FT interactions and by reducing liquid phase condensation of FD protein, which promotes dimerization, leading to FT (...)

Nature

The contribution of rock strength to soil production

mercredi 12 novembre 2025 par Emily C. Geyman, David A. Paige, Michael P. Lamb

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09751-zFindings from a tectonically active mountain range show that soil production is driven by bottom-up rock weakening rather than by soil thickness, challenging long-held top-down (...)

Nature

Mortality impacts of rainfall and sea-level rise in a developing megacity

mercredi 12 novembre 2025 par Tom Bearpark, Ashwin Rode, Archana Patankar

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09730-4High-resolution rainfall, tide and mortaility data are used to quantify the impact of rainfall and flooding on urban health in Mumbai, India, revealing an order-of-magnitude discrepency between observed and officially (...)

Nature

Aligning machine and human visual representations across abstraction levels

mercredi 12 novembre 2025 par Lukas Muttenthaler, Klaus Greff, Frieda Born, Bernhard Spitzer, Simon Kornblith, Michael C. Mozer, Klaus-Robert Müller, Thomas Unterthiner, Andrew K. Lampinen

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09631-6Aligning foundation models with human judgments enables them to more accurately approximate human behaviour and uncertainty across various levels of visual abstraction, while additionally improving their generalization (...)

Nature

Photoinduced twist and untwist of moiré superlattices

mercredi 12 novembre 2025 par Cameron J. R. Duncan, Amalya C. Johnson, Indrajit Maity, Angel Rubio, Matthew Gordon, Adam C. Bartnik, Michael Kaemingk, William H. Li, Matthew B. Andorf, Chad A. Pennington, Ivan V. Bazarov, Mark W. Tate, David A. Muller, Julia Thom-Levy, Sol. M. Gruner, Aaron M. Lindenberg, Jared M. Maxson, Fang Liu

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09707-3Femtosecond photoexcitation drives a coherent twist–untwist motion of the moiré superlattice in 2° and 57° twisted WSe2/MoSe2 heterobilayers.

Nature