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Molecular basis of polyadenylated RNA fate determination in the nucleus

mercredi 17 juin 2026 par Andrii Bugai, Ulrich Hohmann, Ana Lorenzo, Max Graf, Laura Fin, Jérôme O. Rouvière, Laszlo Tirian, Yuhui Dou, Marion Le Rest, Patrik Polák, Dennis Johnsen, Lis Jakobsen, Jens Skorstengaard Andersen, Julius Brennecke, Clemens Plaschka, Torben Heick Jensen

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10650-0Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to (...)

Nature

Rock weathering can counteract river CO₂ emissions induced by permafrost thaw

mercredi 17 juin 2026 par Liwei Zhang, Aaron Bufe, Joshua F. Dean, Gerard Rocher-Ros, Ryan A. Sponseller, Emily H. Stanley, Jan Karlsson, David E. Butman, Ran Liu, Lijun Hou, Jinzhi Ding, Shilong Piao, Xinghui Xia, Tom J. Battin

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10664-8Permafrost thaw on the Qinghai–Tibet Plateau increases rock-weathering rates while reducing river CO2 emissions, suggesting geological carbon fluxes may eventually outpace thaw-driven (...)

Nature

Cortical development dynamics across autism spectrum disorder mouse models

mercredi 17 juin 2026 par Lena A. Schwarz, Christoph P. Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, Bárbara Oliveira, Matteo Barel, Bernadette Basilico, Chaitanya Chintaluri, Sarah Gorkiewicz, Mohammad Goudarzi, Tereza Belinova, Stephan Reichl, Gintar? Sendžikait?, Satish Arcot Jayaram, Peter Koppensteiner, Christoph Sommer, Tim P. Vogels, Jörg Menche, Igor Adameyko, Peter V. Kharchenko, Christoph Bock, Gaia Novarino

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10679-1Using single-nucleus multi-omic sequencing, diverse autism spectrum disorder-linked gene mutations converge on transient, stage-specific disruptions in early brain development, and highlight sex-specific gene expression (...)

Nature

A blastoporal organizer in a ctenophore

mercredi 17 juin 2026 par Stanislav Kremnyov, Tatiana Lebedeva, Grigory Genikhovich, Andreas Hejnol

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10643-zExperiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transition to multicellularity (...)

Nature

Confined migration induces non-lethal DNA damage in developing neurons

mercredi 17 juin 2026 par Zhejing Zhang, Andres Canela, Junko Kurisu, Peilin Zou, Takumi Kawaue, Naotaka Nakazawa, Noriko Takeda, Mai Saeki, Masaki Utsunomiya, Merve Bilgic, Fumiyoshi Ishidate, Gianluca Grenci, Takahiro Furuta, Yusuke Kishi, Hiroyuki Sasanuma, Mineko Kengaku

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10648-8The migration of neurons in developing cerebral and cerebellar cortices is accompanied by massive DNA double-strand breaks due to mechanostress during passage through narrow interstitial (...)

Nature

A mosaic of whole-body representations on the human precentral gyrus

mercredi 17 juin 2026 par Darrel R. Deo, Elizaveta V. Okorokova, Anna L. Pritchard, Nick V. Hahn, Nicholas S. Card, Samuel R. Nason-Tomaszewski, Justin Jude, Thomas Hosman, Eun Young Choi, Deqiang Qiu, Yuguang Meng, Maitreyee Wairagkar, Claire Nicolas, Foram B. Kamdar, Carrina Iacobacci, Alexander Acosta, Leigh R. Hochberg, Sydney S. Cash, Ziv M. Williams, Daniel B. Rubin, David M. Brandman, Sergey D. Stavisky, Nicholas AuYong, Chethan Pandarinath, John E. Downey, Sliman J. Bensmaia, Jaimie M. Henderson, Francis R. Willett

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10653-xA comprehensive map of the human motor cortex at single-neuron resolution is described.

Nature

Spatial distribution of the proteome in the human body and in cancers

mercredi 17 juin 2026 par Liang Yue, Wenhao Jiang, Sainan Li, Meng Luo, Ning Fan, Xiaolu Zhan, Rui Sun, Honghan Cheng, Zhangzhi Xue, Tong Liu, Qianhe Zhou, Kexin Chen, Tian Lu, Fang Guo, Dongwei Li, Weigang Ge, Zongxiang Nie, Mengge Lyu, Jun A, Yingrui Wang, Yingdan Chen, Zhenhai Fu, Nan Xiang, Lu Li, Fengchao Yu, Guo Ci Teo, Alexey I. Nesvizhskii, Meng Wang, Michael P. Snyder, Ben C. Collins, Qi Xiao, Ruedi Aebersold, Fei Xu, Hui Yang, Sijia Zhang, Yi Han, Yi Zhu, Yong Ji, Yan Li, Tiannan Guo

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10660-yA spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of therapeutic targets and (...)

Nature

Lethal plague outbreaks in Lake Baikal hunter-gatherers 5,500 years ago

mercredi 17 juin 2026 par Ruairidh Macleod, Frederik V. Seersholm, Bianca De Sanctis, Angela Lieverse, Adrian Timpson, Rick Schulting, Jesper T. Stenderup, Charleen Gaunitz, Lasse Vinner, Olga Ivanovna Goriunova, Vladimir Ivanovich Bazaliiskii, Sergei V. Vasilyev, Erin Jessup, Yucheng Wang, Christopher Bronk Ramsey, Mark G. Thomas, Russell Corbett-Detig, Astrid K. N. Iversen, Andrzej W. Weber, Martin Sikora, Eske Willerslev

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10540-5Analyses of ancient DNA from hunter-gatherers near Lake Baikal in southeast Siberia around 5,500 years ago indicate that highly virulent Yersinia pestis emerged earlier than previously estimated, far from the next known cases (...)

Nature

Mapping the neuronal building blocks of human language with language models

mercredi 17 juin 2026 par Jing Cai, Yoav Kfir, Mohsen Jamali, Hesen Huang, Young Joon Kim, Sydney S. Cash, Ziv M. Williams

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10691-5Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the higher-order syntactic structure of (...)

Nature

CHPO coordinates chilling recovery and nitrogen use in rice

mercredi 17 juin 2026 par Jie Cao, Yunyuan Xu, Zhitao Li, Jingdan Han, Qian Qian, Song Ge, Hong Wang, Wei Luo, Kang Chong

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10682-6A rice gene, CHPO, links chilling resilience with nitrogen-use efficiency, revealing a domestication-shaped regulatory mechanism that could guide breeding of climate-resilient, sustainable rice (...)

Nature