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GABAergic neuron-to-glioma synapses in diffuse midline gliomas

mercredi 19 février 2025 par Tara Barron, Belgin Yalç?n, Minhui Su, Youkyeong Gloria Byun, Avishai Gavish, Kiarash Shamardani, Haojun Xu, Lijun Ni, Neeraj Soni, Vilina Mehta, Samin Maleki Jahan, Yoon Seok Kim, Kathryn R. Taylor, Michael B. Keough, Michael A. Quezada, Anna C. Geraghty, Rebecca Mancusi, Linh Thuy Vo, Enrique Herrera Castañeda, Pamelyn J. Woo, Claudia K. Petritsch, Hannes Vogel, Kai Kaila, Michelle Monje

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08579-3Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.

Nature

De novo design of transmembrane fluorescence-activating proteins

mercredi 19 février 2025 par Jingyi Zhu, Mingfu Liang, Ke Sun, Yu Wei, Ruiying Guo, Lijing Zhang, Junhui Shi, Dan Ma, Qi Hu, Gaoxingyu Huang, Peilong Lu

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08598-8A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.

Nature

Newfound bat virus that uses notorious receptor poses ‘spillover’ risk

mercredi 19 février 2025

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00503-7The virus is related to the pathogen that causes Middle East respiratory syndrome and capitalizes on the same ‘entry receptor’ used by SARS-CoV-2.

Nature

RNA neoantigen vaccines prime long-lived CD8⁺ T cells in pancreatic cancer

mercredi 19 février 2025 par Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson, Jayon Lihm, George Payne, Olga Lyudovyk, Luis A. Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M. Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yadav, Taha Merghoub, Jedd D. Wolchok, Olca Basturk, Mithat Gönen, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni Desai, Alice C. Wei, Michael I. D’Angelica, T. Peter Kingham, Kevin C. Soares, William R. Jarnagin, Jeffrey Drebin, Eileen M. O’Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D. Greenbaum, Vinod P. Balachandran

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08508-4In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of (...)

Nature

World and Human Action Models towards gameplay ideation

mercredi 19 février 2025 par Anssi Kanervisto, Dave Bignell, Linda Yilin Wen, Martin Grayson, Raluca Georgescu, Sergio Valcarcel Macua, Shan Zheng Tan, Tabish Rashid, Tim Pearce, Yuhan Cao, Abdelhak Lemkhenter, Chentian Jiang, Gavin Costello, Gunshi Gupta, Marko Tot, Shu Ishida, Tarun Gupta, Udit Arora, Ryen W. White, Sam Devlin, Cecily Morrison, Katja Hofmann

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08600-3A state-of-the-art generative artificial intelligence model of a video game is introduced to allow the support of human creative ideation, with the analysis of user study data highlighting three necessary capabilities, (...)

Nature

Mechanism for local attenuation of DNA replication at double-strand breaks

mercredi 19 février 2025 par Robin Sebastian, Eric G. Sun, Michael Fedkenheuer, Haiqing Fu, SeolKyoung Jung, Bhushan L. Thakur, Christophe E. Redon, Gianluca Pegoraro, Andy D. Tran, Jacob M. Gross, Sara Mosavarpour, Nana Afua Kusi, Anagh Ray, Anjali Dhall, Lorinc S. Pongor, Rafael Casellas, Mirit I. Aladjem

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08557-9DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA (...)

Nature

Sequence clustering confounds AlphaFold2

mercredi 19 février 2025 par Joseph W. Schafer, Myeongsang Lee, Devlina Chakravarty, Joseph F. Thole, Ethan A. Chen, Lauren L. Porter

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08267-2Sequence clustering confounds AlphaFold2

Nature

Insufficient evidence for natural selection associated with the Black Death

mercredi 19 février 2025 par Alison R. Barton, Cindy G. Santander, Pontus Skoglund, Ida Moltke, David Reich, Iain Mathieson

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08496-5Insufficient evidence for natural selection associated with the Black Death

Nature

Atlantic oceanic droughts do not threaten Asian water tower

mercredi 19 février 2025 par Yutong Zhao, Chaoyi Xu, Xiaoyu Yu, Yigang Liu, Xinhui Ji

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08357-1Atlantic oceanic droughts do not threaten Asian water tower

Nature

Author Correction: Seasonal advance of intense tropical cyclones in a warming climate

mercredi 19 février 2025 par Kaiyue Shan, Yanluan Lin, Pao-Shin Chu, Xiping Yu, Fengfei Song

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08691-yAuthor Correction: Seasonal advance of intense tropical cyclones in a warming climate

Nature