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A first update on mapping the human genetic architecture of COVID-19

mercredi 3 août 2022 par Gita A. Pathak, Juha Karjalainen, Christine Stevens, Benjamin M. Neale, Mark Daly, Andrea Ganna, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Renato Polimanti, Nadia Harerimana, Matti Pirinen, Rachel G. Liao, Karolina Chwialkowska, Amy Trankiem, Mary K. Balaconis, Huy Nguyen, Matthew Solomonson, Kumar Veerapen, Brooke Wolford, Genevieve Roberts, Danny Park, Catherine A. Ball, Marie Coignet, Shannon McCurdy, Spencer Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Milos Pavlovic, Eurie L. Hong, Kristin Rand, Ahna Girshick, Harendra Guturu, Asher Haug Baltzell, Mari E. K. Niemi, Souad Rahmouni, Julien Guntz, Yves Beguin, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoit Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Stéphanie Gofflot, Sabine Claassen, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Léonard, Frederic Frippiat, Jean-Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Yasmine Belhaj, Bernard Lambermont, Tomoko Nakanishi, David R. Morrison, Vincent Mooser, J. Brent Richards, Guillaume Butler-Laporte, Vincenzo Forgetta, Rui Li, Biswarup Ghosh, Laetitia Laurent, Alexandre Belisle, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madeleine Durand, Erwin Schurr, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, Michaël Chassé, Daniel E. Kaufmann, G. Mark Lathrop, Darin Adra, Caroline Hayward, Joseph T. Glessner, Douglas M. Shaw, Archie Campbell, Marcela Morris, Hakon Hakonarson, David J. Porteous, Jennifer Below, Anne Richmond, Xiao Chang, Hannah Polikowski, Petty E. Lauren, Hung-Hsin Chen, Zhu Wanying, Chloe Fawns-Ritchie, Kari North, Joseph B. McCormick, Joseph R. Glessner, Christopher R. Gignoux, Stephen J. Wicks, Kristy Crooks, Kathleen C. Barnes, Michelle Daya, Jonathan Shortt, Nicholas Rafaels, Sameer Chavan, Paul R. H. J. Timmers, James F. Wilson, Albert Tenesa, Shona M. Kerr, Kenton D’Mellow, Doaa Shahin, Yasser M. El-Sherbiny, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M. Eltoukhy, Lindokuhle Nkambul, Tamer A. Elhadidy, Mohamed S. Abd Elghafar, Jehan J. El-Jawhari, Attia A. S. Mohamed, Marwa H. Elnagdy, Amr Samir, Mahmoud Abdel-Aziz, Walid T. Khafaga, Walaa M. El-Lawaty, Mohamed S. Torky, Mohamed R. El-shanshory, Amr M. Yassen, Mohamed A. F. Hegazy, Kamal Okasha, Mohammed A. Eid, Hanteera S. Moahmed, Carolina Medina-Gomez, M. Arfan Ikram, Andre G. Uitterlinden, Reedik Mägi, Lili Milani, Andres Metspalu, Triin Laisk, Kristi Läll, Maarja Lepamets, Tõnu Esko, Ene Reimann, Paul Naaber, Edward Laane, Jaana Pesukova, Pärt Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, Chiara Batini, Martin D. Tobin, Laura D. Venn, Paul H. Lee, Nick Shrine, Alexander T. Williams, Anna L. Guyatt, Catherine John, Richard J. Packer, Altaf Ali, Robert C. Free, Xueyang Wang, Louise V. Wain, Edward J. Hollox, Catherine E. Bee, Emma L. Adams, Aarno Palotie, Samuli Ripatti, Sanni Ruotsalainen, Kati Kristiansson, Sami Koskelainen, Markus Perola, Kati Donner, Katja Kivinen, Mari Kaunisto, Carlo Rivolta, Pierre-Yves Bochud, Stéphanie Bibert, Noémie Boillat, Semira Gonseth Nussle, Werner Albrich, Mathieu Quinodoz, Dhryata Kamdar, Noémie Suh, Dionysios Neofytos, Véronique Erard, Cathy Voide, R. Friolet, P. Vollenweider, J. L. Pagani, M. Oddo, F. Meyer zu Bentrup, A. Conen, O. Clerc, O. Marchetti, A. Guillet, C. Guyat-Jacques, S. Foucras, M. Rime, J. Chassot, M. Jaquet, R. Merlet Viollet, Y. Lannepoudenx, L. Portopena, P. Y. Bochud, F. Desgranges, P. Filippidis, B. Guéry, D. Haefliger, E. E. Kampouri, O. Manuel, A. Munting, M. Papadimitriou-Olivgeris, J. Regina, L. Rochat-Stettler, V. Suttels, E. Tadini, J. Tschopp, M. Van Singer, B. Viala, N. Boillat-Blanco, T. Brahier, O. Hügli, J. Y. Meuwly, O. Pantet, S. Gonseth Nussle, M. Bochud, V. D’Acremont, S. Estoppey Younes, W. C. Albrich, N. Suh, A. Cerny, L. O’Mahony, C. von Mering, M. Frischknecht, G-R. Kleger, M. Filipovic, C. R. Kahlert, H. Wozniak, T. Rochat Negro, J. Pugin, K. Bouras, C. Knapp, T. Egger, A. Perret, P. Montillier, C. di Bartolomeo, B. Barda, Rafael de Cid, Anna Carreras, Victor Moreno, Manolis Kogevinas, Iván Galván-Femenía, Natalia Blay, Xavier Farré, Lauro Sumoy, Beatriz Cortés, Josep Maria Mercader, Marta Guindo-Martinez, David Torrents, Judith Garcia-Aymerich, Gemma Castaño-Vinyals, Carlota Dobaño, Marco Gori, Alessandra Renieri, Francesca Mari, Mario Umberto Mondelli, Francesco Castelli, Massimo Vaghi, Stefano Rusconi, Francesca Montagnani, Elena Bargagli, Federico Franchi, Maria Antonietta Mazzei, Luca Cantarini, Danilo Tacconi, Marco Feri, Raffaele Scala, Genni Spargi, Cesira Nencioni, Maria Bandini, Gian Piero Caldarelli, Anna Canaccini, Agostino Ognibene, Antonella D’Arminio Monforte, Massimo Girardis, Andrea Antinori, Daniela Francisci, Elisabetta Schiaroli, Pier Giorgio Scotton, Sandro Panese, Renzo Scaggiante, Matteo Della Monica, Mario Capasso, Giuseppe Fiorentino, Marco Castori, Filippo Aucella, Antonio Di Biagio, Luca Masucci, Serafina Valente, Marco Mandalà, Patrizia Zucchi, Ferdinando Giannattasio, Domenico A. Coviello, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Marco Rizzi, Maria Teresa La Rovere, Simona Sarzi-Braga, Maurizio Bussotti, Sabrina Ravaglia, Rosangela Artuso, Antonio Perrella, Davide Romani, Paola Bergomi, Emanuele Catena, Antonella Vincenti, Claudio Ferri, Davide Grassi, Gloria Pessina, Mario Tumbarello, Massimo Di Pietro, Ravaglia Sabrina, Sauro Luchi, Simone Furini, Simona Dei, Elisa Benetti, Nicola Picchiotti, Maurizio Sanarico, Stefano Ceri, Pietro Pinoli, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Kristina Zguro, Katia Capitani, Marco Tanfoni, Chiara Fallerini, Sergio Daga, Margherita Baldassarri, Francesca Fava, Elisa Frullanti, Floriana Valentino, Gabriella Doddato, Annarita Giliberti, Rossella Tita, Sara Amitrano, Mirella Bruttini, Susanna Croci, Ilaria Meloni, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Giada Beligni, Andrea Tommasi, Laura Di Sarno, Maria Palmieri, Miriam Lucia Carriero, Diana Alaverdian, Stefano Busani, Raffaele Bruno, Marco Vecchia, Mary Ann Belli, Stefania Mantovani, Serena Ludovisi, Eugenia Quiros-Roldan, Melania Degli Antoni, Isabella Zanella, Matteo Siano, Arianna Emiliozzi, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana D’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Susanna Guerrini, Edoardo Conticini, Bruno Frediani, Chiara Spertilli, Alice Donati, Luca Guidelli, Marta Corridi, Leonardo Croci, Paolo Piacentini, Elena Desanctis, Silvia Cappelli, Agnese Verzuri, Valentina Anemoli, Alessandro Pancrazzi, Maria Lorubbio, Federica Gaia Miraglia, Sophie Venturelli, Andrea Cossarizza, Alessandra Vergori, Arianna Gabrieli, Agostino Riva, Francesco Paciosi, Francesca Andretta, Francesca Gatti, Saverio Giuseppe Parisi, Stefano Baratti, Carmelo Piscopo, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Massimo Carella, Giuseppe Merla, Gabriella Maria Squeo, Pamela Raggi, Carmen Marciano, Rita Perna, Matteo Bassetti, Maurizio Sanguinetti, Alessia Giorli, Lorenzo Salerni, Pierpaolo Parravicini, Elisabetta Menatti, Tullio Trotta, Gabriella Coiro, Fabio Lena, Enrico Martinelli, Sandro Mancarella, Chiara Gabbi, Franco Maggiolo, Diego Ripamonti, Tiziana Bachetti, Claudia Suardi, Gianfranco Parati, Giordano Bottà, Paolo Di Domenico, Ilaria Rancan, Francesco Bianchi, Riccardo Colombo, Chiara Barbieri, Donatella Acquilini, Elena Andreucci, Francesco Vladimiro Segala, Giusy Tiseo, Marco Falcone, Mirjam Lista, Monica Poscente, Oreste De Vivo, Paola Petrocelli, Alessandra Guarnaccia, Silvia Baroni, David A. van Heel, Karen A. Hunt, Richard C. Trembath, Qin Qin Huang, Hilary C. Martin, Dan Mason, Bhavi Trivedi, John Wright, Sarah Finer, Shaheen Akhtar, Mohammad Anwar, Elena Arciero, Samina Ashraf, Gerome Breen, Raymond Chung, Charles J. Curtis, Maharun Chowdhury, Grainne Colligan, Panos Deloukas, Ceri Durham, Chris Griffiths, Matt Hurles, Shapna Hussain, Kamrul Islam, Ahsan Khan, Amara Khan, Cath Lavery, Sang Hyuck Lee, Robin Lerner, Daniel MacArthur, Bev MacLaughlin, Hilary Martin, Shefa Miah, Bill Newman, Nishat Safa, Farah Tahmasebi, Christopher J. Griffiths, Albert V. Smith, Andrew P. Boughton, Kevin W. Li, Jonathon LeFaive, Aubrey Annis, Ahmadreza Niavarani, Rasoul Aliannejad, Bahareh Sharififard, Ali Amirsavadkouhi, Zeinab Naderpour, Hengameh Ansari Tadi, Afshar Etemadi Aleagha, Saeideh Ahmadi, Seyed Behrooz Mohseni Moghaddam, Alireza Adamsara, Morteza Saeedi, Hamed Abdollahi, Abdolmajid Hosseini, Pajaree Chariyavilaskul, Watsamon Jantarabenjakul, Nattiya Hirankarn, Monpat Chamnanphon, Thitima B. Suttichet, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Opass Putchareon, Pattama Torvorapanit, Thanyawee Puthanakit, Pintip Suchartlikitwong, Voraphoj Nilaratanakul, Pimpayao Sodsai, Ben M. Brumpton, Kristian Hveem, Cristen Willer, Wei Zhou, Tormod Rogne, Erik Solligard, Bjørn Olav Åsvold, Lude Franke, Marike Boezen, Patrick Deelen, Annique Claringbould, Esteban Lopera, Robert Warmerdam, Judith. M. Vonk, Irene van Blokland, Pauline Lanting, Anil P. S. Ori, Yen-Chen Anne Feng, Josep Mercader, Scott T. Weiss, Elizabeth W. Karlson, Jordan W. Smoller, Shawn N. Murphy, James B. Meigs, Ann E. Woolley, Robert C. Green, Emma F. Perez, Sebastian Zöllner, Jiongming Wang, Andrew Beck, Laura G. Sloofman, Steven Ascolillo, Robert P. Sebra, Brett L. Collins, Tess Levy, Joseph D. Buxbaum, Stuart C. Sealfon, Daniel M. Jordan, Ryan C. Thompson, Kyle Gettler, Kumardeep Chaudhary, Gillian M. Belbin, Michael Preuss, Clive Hoggart, Sam Choi, Slayton J. Underwood, Irene Salib, Bari Britvan, Katherine Keller, Lara Tang, Michael Peruggia, Liam L. Hiester, Kristi Niblo, Alexandra Aksentijevich, Alexander Labkowsky, Avromie Karp, Menachem Zlatopolsky, Marissa Zyndorf, Alexander W. Charney, Noam D. Beckmann, Eric E. Schadt, Noura S. Abul-Husn, Judy H. Cho, Yuval Itan, Eimear E. Kenny, Ruth J. F. Loos, Girish N. Nadkarni, Ron Do, Paul O’Reilly, Laura M. Huckins, Manuel A. R. Ferreira, Goncalo R. Abecasis, Joseph B. Leader, Michael N. Cantor, Anne E. Justice, Dave J. Carey, Geetha Chittoor, Navya Shilpa Josyula, Jack A. Kosmicki, Julie E. Horowitz, Aris Baras, Matthew C. Gass, Ashish Yadav, Tooraj Mirshahi, Jouke Jan Hottenga, Meike Bartels, Eco E. J. C. de geus, Michel M. G. Nivard, Anurag Verma, Marylyn D. Ritchie, Daniel Rader, Binglan Li, Shefali S. Verma, Anastasia Lucas, Yuki Bradford, Malak Abedalthagafi, Manal Alaamery, Abdulraheem Alshareef, Mona Sawaji, Salam Massadeh, Abdulaziz AlMalik, Saleh Alqahtani, Dona Baraka, Fawz Al Harthi, Ebtehal Alsolm, Leen Abu Safieh, Albandary M. Alowayn, Fatimah Alqubaishi, Amal Al Mutairi, Serghei Mangul, Mansour Almutairi, Nora Aljawini, Nour Albesher, Yaseen M. Arabi, Ebrahim S. Mahmoud, Amin K. Khattab, Roaa T. Halawani, Ziab Z. Alahmadey, Jehad K. Albakri, Walaa A. Felemban, Bandar A. Suliman, Rana Hasanato, Laila Al-Awdah, Jahad Alghamdi, Deema AlZahrani, Sameera AlJohani, Hani Al-Afghani, Nouf AlDhawi, Hadeel AlBardis, Sarah Alkwai, Moneera Alswailm, Faisal Almalki, Maha Albeladi, Iman Almohammed, Eman Barhoush, Anoud Albader, Sara Alotaibi, Bader Alghamdi, Junghyun Jung, Mohammad S. fawzy, May Alrashed, Hugo Zeberg, Lindo Nkambul, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Nicolas Tardif, Olav Rooyackers, Jonathan Grip, Tomislav Maricic, Øyvind Helgeland, Per Magnus, Lill-Iren S. Trogstad, Yunsung Lee, Jennifer R. Harris, Massimo Mangino, Tim D. Spector, Duncan Emma, Loukas Moutsianas, Mark J. Caulfield, Richard H. Scott, Athanasios Kousathanas, Dorota Pasko, Susan Walker, Alex Stuckey, Christopher A. Odhams, Daniel Rhodes, Tom Fowler, Augusto Rendon, Georgia Chan, Prabhu Arumugam, Konrad J. Karczewski, Alicia R. Martin, Daniel J. Wilson, Chris C. A. Spencer, Derrick W. Crook, David H. Wyllie, Anne Marie O’Connell, Elizabeth G. Atkinson, Kristin Tsuo, Nikolas Baya, Patrick Turley, Rahul Gupta, Raymond K. Walters, Duncan S. Palmer, Gopal Sarma, Nathan Cheng, Wenhan Lu, Claire Churchhouse, Jacqueline I. Goldstein, Daniel King, Cotton Seed, Mark J. Daly, Hilary Finucane, Sam Bryant, F. Kyle Satterstrom, Gavin Band, Sarah G. Earle, Shang-Kuan Lin, Nicolas Arning, Nils Koelling, Jacob Armstrong, Justine K. Rudkin, Shawneequa Callier, Caroline Cusick, Nicole Soranzo, Jing Hua Zhao, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Yan V. Sun, Jennifer E. Huffman, Kelly Cho, Christopher J. O’Donnell, Phil Tsao, J. Michael Gaziano, Gina Peloso, Yuk-Lam Ho, Sandra P. Smieszek, Christos Polymeropoulos, Vasilios Polymeropoulos, Mihael H. Polymeropoulos, Bartlomiej P. Przychodzen, Israel Fernandez-Cadenas, Anna M. Planas, Jordi Perez-Tur, Laia Llucià-Carol, Natalia Cullell, Elena Muiño, Jara Cárcel-Márquez, Marta L. DeDiego, Lara Lloret Iglesias, Alex Soriano, Veronica Rico, Daiana Agüero, Josep L. Bedini, Francisco Lozano, Carlos Domingo, Veronica Robles, Francisca Ruiz-Jaén, Leonardo Márquez, Juan Gomez, Eliecer Coto, Guillermo M. Albaiceta, Marta García-Clemente, David Dalmau, Maria J. Arranz, Beatriz Dietl, Alex Serra-Llovich, Pere Soler, Roger Colobrán, Andrea Martín-Nalda, Alba Parra Martínez, David Bernardo, Silvia Rojo, Aida Fiz-López, Elisa Arribas, Paloma de la Cal-Sabater, Tomás Segura, Esther González-Villa, Gemma Serrano-Heras, Joan Martí-Fàbregas, Elena Jiménez-Xarrié, Alicia de Felipe Mimbrera, Jaime Masjuan, Sebastian García-Madrona, Anna Domínguez-Mayoral, Joan Montaner Villalonga, Paloma Menéndez-Valladares, Daniel I. Chasman, Howard D. Sesso, JoAnn E. Manson, Julie E. Buring, Paul M. Ridker, Giulianini Franco, Lea Davis, Sulggi Lee, James Priest, Vijay G. Sankaran, David van Heel, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-04826-7A first update on mapping the human genetic architecture of COVID-19

A mitotic chromatin phase transition prevents perforation by microtubules

mercredi 3 août 2022 par Maximilian W. G. Schneider, Bryan A. Gibson, Shotaro Otsuka, Maximilian F. D. Spicer, Mina Petrovic, Claudia Blaukopf, Christoph C. H. Langer, Paul Batty, Thejaswi Nagaraju, Lynda K. Doolittle, Michael K. Rosen, Daniel W. Gerlich
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05027-yHistone deacetylation at the onset of mitosis induces a chromatin-intrinsic phase transition that endows chromosomes with the physical characteristics necessary for their precise movement during cell (...)

Premier balayage de la région centrale de la Voie Lactée en rayons gamma de très hautes énergies

mardi 2 août 2022 par Alain Redbran — Astrophysique
La collaboration H.E.S.S. a mené depuis plusieurs années une vaste campagne d'observations pour couvrir plusieurs centaines de parsecs autour du centre Galactique. Cette campagne d'observations...

Pourquoi certains oiseaux sont-ils plus intelligents que d'autres ?

mardi 2 août 2022 par Adrien Bernard — Vie et Terre
Si vous avez déjà vu un quiscale voler la nourriture sèche de votre chien ou un étourneau picorer un sac à ordures, vous pourriez penser que certains oiseaux ont appris à tirer parti de...

Heart disease after COVID: what the data say

mardi 2 août 2022 par Saima May Sidik
Nature, Published online: 02 August 2022; doi:10.1038/d41586-022-02074-3Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of (...)

Retractions are increasing, but not enough

mardi 2 août 2022 par Ivan Oransky
Nature, Published online: 02 August 2022; doi:10.1038/d41586-022-02071-6Retraction Watch has witnessed a retraction boom since its founding 12 years ago. But the scientific community must do much more.

Structures and mechanisms of the Arabidopsis auxin transporter PIN3

mardi 2 août 2022 par Nannan Su, Aiqin Zhu, Xin Tao, Zhong Jie Ding, Shenghai Chang, Fan Ye, Yan Zhang, Cheng Zhao, Qian Chen, Jiangqin Wang, Chen Yu Zhou, Yirong Guo, Shasha Jiao, Sufen Zhang, Han Wen, Lixin Ma, Sheng Ye, Shao Jian Zheng, Fan Yang, Shan Wu, Jiangtao Guo
Nature, Published online: 02 August 2022; doi:10.1038/s41586-022-05142-wStructures and mechanisms of the Arabidopsis auxin transporter PIN3

Balloon flotilla detects an earthquake from high in the sky

mardi 2 août 2022
Nature, Published online: 02 August 2022; doi:10.1038/d41586-022-02028-9Sensors on board balloons identified a 2021 quake from thousands of kilometres away, suggesting that they could do the same on other planets.

Escort proteins for cellular zinc ions

mardi 2 août 2022 par Wolfgang Maret
Nature, Published online: 02 August 2022; doi:10.1038/d41586-022-01988-2A metallochaperone protein that ensures that zinc ions are delivered to a crucial cellular enzyme has now been discovered. The finding underscores the subtleties of controlling cellular zinc allocation when the metal is (...)

How AlphaFold can realize AI’s full potential in structural biology

mardi 2 août 2022
Nature, Published online: 02 August 2022; doi:10.1038/d41586-022-02088-xTo make the most of artificial intelligence, data and software must be freely shared, and computational, theoretical and experimental researchers must work together (...)

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