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RNA editing underlies genetic risk of common inflammatory diseases

mercredi 3 août 2022 par Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, Tao Sun, Gokul Ramaswami, Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05052-xcis-RNA editing quantitative trait loci, which are associated with immunogenic double-stranded RNAs, underlie genome-wide association study variants in common autoimmune and inflammatory (...)

Transformations of neural representations in a social behaviour network

mercredi 3 août 2022 par Bin Yang, Tomomi Karigo, David J. Anderson
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05057-6BNSTprEsr1 activity is required to gate the transition from appetitive to consummatory male social behaviours towards both sexes, by controlling sex- and behaviour-specific representations in VMHvl and MPOA, (...)

Long-sought mediator of vitamin K recycling discovered

mercredi 3 août 2022 par Nathan P. Ward, Gina M. DeNicola
Nature, Published online: 03 August 2022; doi:10.1038/d41586-022-02001-6The identity of the enzyme that enables vitamin K to combat the adverse side effects of a drug called warfarin has been long sought. Analysis of a type of cell death called ferroptosis has now unexpectedly solved the (...)

The challenge of unprecedented floods and droughts in risk management

mercredi 3 août 2022 par Heidi Kreibich, Anne F. Van Loon, Kai Schröter, Philip J. Ward, Maurizio Mazzoleni, Nivedita Sairam, Guta Wakbulcho Abeshu, Svetlana Agafonova, Amir AghaKouchak, Hafzullah Aksoy, Camila Alvarez-Garreton, Blanca Aznar, Laila Balkhi, Marlies H. Barendrecht, Sylvain Biancamaria, Liduin Bos-Burgering, Chris Bradley, Yus Budiyono, Wouter Buytaert, Lucinda Capewell, Hayley Carlson, Yonca Cavus, Anaïs Couasnon, Gemma Coxon, Ioannis Daliakopoulos, Marleen C. de Ruiter, Claire Delus, Mathilde Erfurt, Giuseppe Esposito, Didier François, Frédéric Frappart, Jim Freer, Natalia Frolova, Animesh K. Gain, Manolis Grillakis, Jordi Oriol Grima, Diego A. Guzmán, Laurie S. Huning, Monica Ionita, Maxim Kharlamov, Dao Nguyen Khoi, Natalie Kieboom, Maria Kireeva, Aristeidis Koutroulis, Waldo Lavado-Casimiro, Hong-Yi Li, María Carmen LLasat, David Macdonald, Johanna Mård, Hannah Mathew-Richards, Andrew McKenzie, Alfonso Mejia, Eduardo Mario Mendiondo, Marjolein Mens, Shifteh Mobini, Guilherme Samprogna Mohor, Viorica Nagavciuc, Thanh Ngo-Duc, Thi Thao Nguyen Huynh, Pham Thi Thao Nhi, Olga Petrucci, Hong Quan Nguyen, Pere Quintana-Seguí, Saman Razavi, Elena Ridolfi, Jannik Riegel, Md Shibly Sadik, Elisa Savelli, Alexey Sazonov, Sanjib Sharma, Johanna Sörensen, Felipe Augusto Arguello Souza, Kerstin Stahl, Max Steinhausen, Michael Stoelzle, Wiwiana Szalińska, Qiuhong Tang, Fuqiang Tian, Tamara Tokarczyk, Carolina Tovar, Thi Van Thu Tran, Marjolein H. J. Van Huijgevoort, Michelle T. H. van Vliet, Sergiy Vorogushyn, Thorsten Wagener, Yueling Wang, Doris E. Wendt, Elliot Wickham, Long Yang, Mauricio Zambrano-Bigiarini, Günter Blöschl, Giuliano Di Baldassarre
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-04917-5Unprecedented floods and droughts bring new challenges for risk reduction, as is clear from this analysis of the drivers of changing impacts in many cases worldwide, with implications for efficient governance and investment (...)

Highly efficient blue InGaN nanoscale light-emitting diodes

mercredi 3 août 2022 par Mihyang Sheen, Yunhyuk Ko, Dong-uk Kim, Jongil Kim, Jin-ho Byun, YongSeok Choi, Jonghoon Ha, Ki Young Yeon, Dohyung Kim, Jungwoon Jung, Jinyoung Choi, Ran Kim, Jewon Yoo, Inpyo Kim, Chanwoo Joo, Nami Hong, Joohee Lee, Sang Ho Jeon, Sang Ho Oh, Jaekwang Lee, Nari Ahn, Changhee Lee
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-04933-5Using a sol–gel passivation method, the fabrication of blue InGaN nanorod-LEDs with the highest external quantum efficiency value ever reported for LEDs in the nanoscale is (...)

Timescales for pluton growth, magma-chamber formation and super-eruptions

mercredi 3 août 2022 par M. E. van Zalinge, D. F. Mark, R. S. J. Sparks, M. M. Tremblay, C. B. Keller, F. J. Cooper, A. Rust
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-04921-9Analysis of inherited zircons and sanidines from Miocene ignimbrites in the Central Andes shows that plutons were emplaced for up to 4 million years prior to onset of volcanism and that disruption of plutonic rock occurs a (...)

Non-Hermitian morphing of topological modes

mercredi 3 août 2022 par Wei Wang, Xulong Wang, Guancong Ma
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-04929-1It is experimentally demonstrated that the non-Hermitian skin effect can convert localized topological modes into extended modes of unconventional shapes while preserving the topological characteristics, which presents (...)

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

mercredi 3 août 2022 par Rhythm Shukla, Francesca Lavore, Sourav Maity, Maik G. N. Derks, Chelsea R. Jones, Bram J. A. Vermeulen, Adéla Melcrová, Michael A. Morris, Lea Marie Becker, Xiaoqi Wang, Raj Kumar, João Medeiros-Silva, Roy A. M. van Beekveld, Alexandre M. J. J. Bonvin, Joseph H. Lorent, Moreno Lelli, James S. Nowick, Harold D. MacGillavry, Aaron J. Peoples, Amy L. Spoering, Losee L. Ling, Dallas E. Hughes, Wouter H. Roos, Eefjan Breukink, Kim Lewis, Markus Weingarth
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05019-yUsing a combination of methods, the mechanism of the antibiotic teixobactin is revealed.

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion

mercredi 3 août 2022 par Ju-Qiong Wang, Liang-Liang Li, Ao Hu, Gang Deng, Jian Wei, Yun-Feng Li, Yuan-Bin Liu, Xiao-Yi Lu, Zhi-Ping Qiu, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05006-3Inhibiting the asialoglycoprotein receptor ASGR1 increases cholesterol excretion to the bile and then faeces, providing a unique way to lower cholesterol, and therefore providing a safe and effective way to treat (...)

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

mercredi 3 août 2022 par Thomas G. Laughlin, Amar Deep, Amy M. Prichard, Christian Seitz, Yajie Gu, Eray Enustun, Sergey Suslov, Kanika Khanna, Erica A. Birkholz, Emily Armbruster, J. Andrew McCammon, Rommie E. Amaro, Joe Pogliano, Kevin D. Corbett, Elizabeth Villa
Nature, Published online: 03 August 2022; doi:10.1038/s41586-022-05013-4The nucleus-like compartment formed in bacteria during infection by jumbo phage 201phi2-1 is composed of the bacteriophage protein chimallin, which can self-assemble into closed compartments in (...)

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