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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

mercredi 4 juin 2014 par Baris Bingol, Joy S. Tea, Lilian Phu, Mike Reichelt, Corey E. Bakalarski, Qinghua Song, Oded Foreman, Donald S. Kirkpatrick, Morgan Sheng
Cells maintain healthy mitochondria by degrading damaged mitochondria through mitophagy; defective mitophagy is linked to Parkinson’s disease. Here we report that USP30, a deubiquitinase localized to mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin (also known as PARK2) (...)

Cell biology: Balancing act

mercredi 4 juin 2014 par Alban Ordureau, J. Wade Harper
The enzyme parkin is known to promote disposal of organelles called mitochondria that have suffered damage. The identification of an enzyme that opposes parkin demonstrates how a delicate balance is maintained in the cell. See Article (...)

Population health: Immaturity in the gut microbial community

mercredi 4 juin 2014 par Elizabeth K. Costello, David A. Relman
Undernourished children fall behind not only on growth, but also on maturation of their intestinal bacterial communities, according to a study comparing acutely malnourished and healthy Bangladeshi children. See Letter p.417

Climate change: Fading winter fog threatens crops

mercredi 4 juin 2014
Climate change has reduced the amount of winter fog in California (pictured), possibly damaging the region's fruit and nut crops.Much of the fruit and nut production in the United States comes from the Central Valley of California. Dennis Baldocchi and Eric (...)

Winner takes all in science

mercredi 4 juin 2014 par Chris Woolston
Nature's roundup of the papers and issues gaining traction on social media.As competition grows among researchers for ever-shrinking science budgets, articles about inequalities in funding and new ways to finance labs have recently drawn a lot of clicks and comments.Many researchers (...)

Seven days: 30 May–5 June 2014

mercredi 4 juin 2014
The week in science: US proposes cleaning up power plants; retraction agreed in stem-cell controversy; and new statistics on the global rise in obesity.

Land models put to climate test

mercredi 4 juin 2014 par Jane Qiu
Study under way on Mongolian steppes aims to improve knowledge of warming effects on vegetation.

Federal boost for German science

mercredi 4 juin 2014 par Quirin Schiermeier
Agreement on changes to constitution pave way for university funding shake-up.

Solar energy: Springtime for the artificial leaf

mercredi 4 juin 2014 par Jessica Marshall
Researchers make headway in turning photons into fuel.

Alzheimer's disease: The forgetting gene

mercredi 4 juin 2014 par Laura Spinney
For decades, most researchers ignored the leading genetic risk factor for Alzheimer's disease. That is set to change.

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