Sur le Web

Nouveautés sur le Web

Articles les plus récents

Prolonged persistence of mutagenic DNA lesions in somatic cells

mercredi 15 janvier 2025 par Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori D. Kregar, Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb Parsy, Kate H. C. Gowers, Sam M. Janes, Stanley W. K. Ng, Matt Hoare, Anthony R. Green, George S. Vassiliou, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Iñigo Martincorena, Michael R. Stratton, Jyoti Nangalia, Tim H. H. Coorens, Peter J. Campbell

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08423-8Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational (...)

Nature

The human and non-human primate developmental GTEx projects

mercredi 15 janvier 2025 par Tim H. H. Coorens, Amy Guillaumet-Adkins, Rothem Kovner, Rebecca L. Linn, Victoria H. J. Roberts, Amrita Sule, Patrick M. Van Hoose, Thomas Bell, Thomas Blanchard, Raquel Hernandez, Rebecca Linn, Deanne Taylor, Melissa VonDran, Taha M. Ahooyi, Danette Beitra, Anas Bernieh, Meghan Delaney, Melissa Faith, Emmanouel Fattahi, Dana Footer, Michelle Gilbert, Simoné Guambaña, Sam Gulino, Jade Hanson, Emilie Hattrell, Casie Heinemann, Joseph Kreeb, Daniel Leino, Laurel Mcdevitt, Abigail Palmieri, Mary Pfeiffer, Gloria Pryhuber, Chrisopher Rossi, Immanuel Rasool, Russell Roberts, Ahmad Salehi, Emmitt A. Savannah, Kristen Stachowicz, David Stokes, Lawrence Suplee, Patrick Van Hoose, Benjamin J. Wilkins, Schawnte’ Williams-Taylor, Shiping Zhang, Kristin G. Ardlie, Gad Getz, Tuuli Lappalainen, Stephen B. Montgomery, François Aguet, Lisa Anderson, Brad Bernstein, Abhishek Choudhary, Laura Domenech, Elizabeth Gaskell, Matthew Johnson, Qiuyue Liu, Andrew R. Marderstein, Jared Nedzel, Joseph Okonda, Evin M. Padhi, MaryKate Rosano, Andrew J. C. Russell, Brady Walker, Nenad Sestan, Mark Gerstein, Aleksandar Milosavljevic, Beatrice Borsari, Hyesun Cho, Declan Clarke, Ashley Deveau, Timur Galeev, Kevin Gobeske, Irbaz Hameed, Anita Huttner, Matthew Jensen, Yunzhe Jiang, Jiaqi Li, Jia Liu, Yuting Liu, Jay Ma, Shrikant Mane, Ran Meng, Anandita Nadkarni, Pengyu Ni, Saejeong Park, Varduhi Petrosyan, Sirisha Pochareddy, Iva Salamon, Yan Xia, Chris Yates, Menglei Zhang, Hongyu Zhao, Donald F. Conrad, Guoping Feng, Fritzie Brady, Magalie Boucher, Lucia Carbone, Jenna Castro, Ricardo del Rosario, Madison Held, Jon Hennebold, Ariah Lacey, Anne Lewis, Ana Cristina Lima, Eisa Mahyari, Samantha Moore, Mariam Okhovat, Victoria Roberts, Samia Silva de Castro, Brady Wessel, Heather Zaniewski, Qiangge Zhang, Alexander Arguello, Jacob J. Baroch, Jyoti Dayal, Adam Felsenfeld, John V. Ilekis, Sheethal Jose, Nicole C. Lockhart, Daniel Miller, Mollie Minear, Melissa Parisi, Amanda Price, Erin Ramos, Sige Zou

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08244-9The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood with developmentally matched (...)

Nature

GZMK-expressing CD8⁺ T cells promote recurrent airway inflammatory diseases

mercredi 15 janvier 2025 par Feng Lan, Jizhou Li, Wenxuan Miao, Fei Sun, Su Duan, Yabing Song, Jiacheng Yao, Xiangdong Wang, Chengshuo Wang, Xin Liu, Jianbin Wang, Luo Zhang, Hai Qi

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08395-9Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing Granzyme K, a (...)

Nature

Massively parallel characterization of transcriptional regulatory elements

mercredi 15 janvier 2025 par Vikram Agarwal, Fumitaka Inoue, Max Schubach, Dmitry Penzar, Beth K. Martin, Pyaree Mohan Dash, Pia Keukeleire, Zicong Zhang, Ajuni Sohota, Jingjing Zhao, Ilias Georgakopoulos-Soares, William S. Noble, Galip Gürkan Yard?mc?, Ivan V. Kulakovskiy, Martin Kircher, Jay Shendure, Nadav Ahituv

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08430-9Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory (...)

Nature

Structural insights into RNA cleavage by PIWI Argonaute

mercredi 15 janvier 2025 par Zhiqing Li, Qikui Xu, Jing Zhong, Yan Zhang, Tianxiang Zhang, Xiaoze Ying, Xiaoli Lu, Xiaoyi Li, Li Wan, Junchao Xue, Jing Huang, Ying Zhen, Zhao Zhang, Jianping Wu, En-Zhi Shen

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08438-1After target binding, PIWI proteins undergo a conformational change from ‘open’ to ‘locked’, facilitating base pairing and enhancing target cleavage efficiency, providing insights into how dynamic conformational changes from (...)

Nature

Targeting FOXM1 condensates reduces breast tumour growth and metastasis

mercredi 15 janvier 2025 par Feng Xie, Xiaoxue Zhou, Yu Ran, Ran Li, Jing Zou, Shiyun Wan, Peng Su, Xuli Meng, Haiyan Yan, Huasong Lu, Heng Ru, Hai Hu, Zhengwei Mao, Bing Yang, Fangfang Zhou, Long Zhang

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08421-wThe transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and (...)

Nature

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer

mercredi 15 janvier 2025 par Masataka Amisaki, Abderezak Zebboudj, Hiroshi Yano, Siqi Linsey Zhang, George Payne, Adrienne Kaya Chandra, Rebecca Yu, Pablo Guasp, Zachary M. Sethna, Akihiro Ohmoto, Luis A. Rojas, Charlotte Cheng, Theresa Waters, Alexander Solovyov, Stephen Martis, Ashley S. Doane, Charlotte Reiche, Emmanuel M. Bruno, Martina Milighetti, Kevin Soares, Zagaa Odgerel, John Alec Moral, Julia N. Zhao, Mithat Gönen, Rui Gardner, Alexei V. Tumanov, Abdul G. Khan, Olivia Vergnolle, Elisabeth K. Nyakatura, Ivo C. Lorenz, Manuel Baca, Erin Patterson, Benjamin Greenbaum, David Artis, Taha Merghoub, Vinod P. Balachandran

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08426-5IL-33 induces tertiary lymphoid structures.

Nature

Long-lived entanglement of molecules in magic-wavelength optical tweezers

mercredi 15 janvier 2025 par Daniel K. Ruttley, Tom R. Hepworth, Alexander Guttridge, Simon L. Cornish

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08365-1By engineering an exceptionally controlled environment using rotationally magic optical tweezers, long-lived entanglement between pairs of molecules using detectable hertz-scale interactions can be (...)

Nature

De novo designed proteins neutralize lethal snake venom toxins

mercredi 15 janvier 2025 par Susana Vázquez Torres, Melisa Benard Valle, Stephen P. Mackessy, Stefanie K. Menzies, Nicholas R. Casewell, Shirin Ahmadi, Nick J. Burlet, Edin Muratspahi?, Isaac Sappington, Max D. Overath, Esperanza Rivera-de-Torre, Jann Ledergerber, Andreas H. Laustsen, Kim Boddum, Asim K. Bera, Alex Kang, Evans Brackenbrough, Iara A. Cardoso, Edouard P. Crittenden, Rebecca J. Edge, Justin Decarreau, Robert J. Ragotte, Arvind S. Pillai, Mohamad Abedi, Hannah L. Han, Stacey R. Gerben, Analisa Murray, Rebecca Skotheim, Lynda Stuart, Lance Stewart, Thomas J. A. Fryer, Timothy P. Jenkins, David Baker

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08393-xDeep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible antivenom (...)

Nature

Ensemble reactivations during brief rest drive fast learning of sequences

mercredi 15 janvier 2025 par Sandon Griffin, Preeya Khanna, Hoseok Choi, Katherina Thiesen, Lisa Novik, Robert J. Morecraft, Karunesh Ganguly

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08414-9In macaques, motor cortex activity associated with motor learning tasks is reactivated during brief breaks between learning blocks and predicts subsequent performance (...)

Nature