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Got flu? Promising drug shortens symptoms

mercredi 15 janvier 2025

Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00041-2Influenza viruses have not evolved resistance to suraxavir marboxil, which relieves cough, fever and other symptoms.

Nature

Author Correction: Evolution of immune genes is associated with the Black Death

mercredi 15 janvier 2025 par Jennifer Klunk, Tauras P. Vilgalys, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar, Luis B. Barreiro

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08522-6Author Correction: Evolution of immune genes is associated with the Black Death

Nature

Author Correction: An endosomal tether undergoes an entropic collapse to bring vesicles together

mercredi 15 janvier 2025 par David H. Murray, Marcus Jahnel, Janelle Lauer, Mario J. Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico D. Perini, Charles Ferguson, Andrei N. Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill, Marino Zerial

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08567-7Author Correction: An endosomal tether undergoes an entropic collapse to bring vesicles together

Nature

Engineered enzymes for enantioselective nucleophilic aromatic substitutions

mercredi 15 janvier 2025 par Thomas M. Lister, George W. Roberts, Euan J. Hossack, Fei Zhao, Ashleigh J. Burke, Linus O. Johannissen, Florence J. Hardy, Alexander A. V. Millman, David Leys, Igor Larrosa, Anthony P. Green

Nature, Published online: 15 January 2025; doi:10.1038/s41586-025-08611-0Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Nature

Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques

mercredi 15 janvier 2025 par Kyle Rosenke, Amanda Giffin, Franziska Kaiser, Ekaterina Altynova, Reshma Mukesh, Meaghan Flagg, Thomas Tipih, Kerry Goldin, Arthur Wickenhagen, Brandi N. Williamson, Shane Gallogly, Shanna S. Leventhal, Tessa Lutterman, Atsushi Okumura, Matthew C. Lewis, Kishore Kanakabandi, Craig Martens, Kwe C. Yinda, Deepashri Rao, Brian J. Smith, Carl Shaia, Greg Saturday, Patrick Hanley, Neeltje van Doremalen, Emmie de Wit, Vincent J. Munster, Heinz Feldmann

Nature, Published online: 15 January 2025; doi:10.1038/s41586-025-08609-8Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques

Nature

AI-designed antivenoms could help treat lethal snakebites

mercredi 15 janvier 2025 par Benjamin Thompson, Elizabeth Gibney

Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00134-yProteins made using machine learning successfully bind snake toxins — plus, Earth’s temperature breaks a significant climate threshold for the first time.

Nature

Episodic and associative memory from spatial scaffolds in the hippocampus

mercredi 15 janvier 2025 par Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri, Ila Fiete

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08392-yA neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the (...)

Nature

All-solid-state Li–S batteries with fast solid–solid sulfur reaction

mercredi 15 janvier 2025 par Huimin Song, Konrad Münch, Xu Liu, Kaier Shen, Ruizhuo Zhang, Timo Weintraut, Yuriy Yusim, Dequan Jiang, Xufeng Hong, Jiashen Meng, Yatao Liu, Mengxue He, Yitao Li, Philip Henkel, Torsten Brezesinski, Jürgen Janek, Quanquan Pang

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08298-9By using lithium thioborophosphate iodide glass-phase solid electrolytes in all-solid-state lithium–sulfur batteries, fast solid–solid sulfur redox reaction is demonstrated, leading to cells with ultrafast charging (...)

Nature

Continental influx and pervasive matrilocality in Iron Age Britain

mercredi 15 janvier 2025 par Lara M. Cassidy, Miles Russell, Martin Smith, Gabrielle Delbarre, Paul Cheetham, Harry Manley, Valeria Mattiangeli, Emily M. Breslin, Iseult Jackson, Maeve McCann, Harry Little, Ciarán G. O’Connor, Beth Heaslip, Daniel Lawson, Phillip Endicott, Daniel G. Bradley

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08409-6An analysis of ancient mitochondrial and nuclear DNA shows evidence of matrilocal communities in Iron Age Britain.

Nature

Targeting protein–ligand neosurfaces with a generalizable deep learning tool

mercredi 15 janvier 2025 par Anthony Marchand, Stephen Buckley, Arne Schneuing, Martin Pacesa, Maddalena Elia, Pablo Gainza, Evgenia Elizarova, Rebecca M. Neeser, Pao-Wan Lee, Luc Reymond, Yangyang Miao, Leo Scheller, Sandrine Georgeon, Joseph Schmidt, Philippe Schwaller, Sebastian J. Maerkl, Michael Bronstein, Bruno E. Correia

Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08435-4A computational deep learning approach is used to design synthetic proteins that target the neosurfaces formed by protein–ligand interactions, with applications in the development of new therapeutic modalities such as (...)

Nature