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Mutant clones in normal epithelium outcompete and eliminate emerging tumours

mercredi 13 octobre 2021 par B. Colom, A. Herms, M. W. J. Hall, S. C. Dentro, C. King, R. K. Sood, M. P. Alcolea, G. Piedrafita, D. Fernandez-Antoran, S. H. Ong, J. C. Fowler, K. T. Mahbubani, K. Saeb-Parsy, M. Gerstung, B. A. Hall, P. H. Jones
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03965-7The rarity of tumour formation despite the high proportion of cancer-driver mutations in epithelia is explained by the competitive fitness of tumour cells relative to that of surrounding mutant epithelial (...)

Day–night cloud asymmetry prevents early oceans on Venus but not on Earth

mercredi 13 octobre 2021 par Martin Turbet, Emeline Bolmont, Guillaume Chaverot, David Ehrenreich, Jérémy Leconte, Emmanuel Marcq
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03873-wGlobal climate model simulations of early Venus and Earth show that differences in the cloud regimes prevented ocean formation on Venus but not on Earth.

Oestrogen engages brain MC4R signalling to drive physical activity in female mice

mercredi 13 octobre 2021 par William C. Krause, Ruben Rodriguez, Bruno Gegenhuber, Navneet Matharu, Andreas N. Rodriguez, Adriana M. Padilla-Roger, Kenichi Toma, Candice B. Herber, Stephanie M. Correa, Xin Duan, Nadav Ahituv, Jessica Tollkuhn, Holly A. Ingraham
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-04010-3A subset of oestrogen-sensitive neurons integrate melanocortin and oestrogen signalling to rebalance energy allocation in female mice leading to reduced sedentary behaviour and decreasing obesity in oestrogen-depleted (...)

Observation of fractional edge excitations in nanographene spin chains

mercredi 13 octobre 2021 par Shantanu Mishra, Gonçalo Catarina, Fupeng Wu, Ricardo Ortiz, David Jacob, Kristjan Eimre, Ji Ma, Carlo A. Pignedoli, Xinliang Feng, Pascal Ruffieux, Joaquín Fernández-Rossier, Roman Fasel
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03842-3Using scanning tunnelling microscopy and spectroscopy, fractional edge excitations are observed in nanographene spin chains, enabling the potential to study strongly correlated phases in purely organic (...)

How electric acupuncture zaps inflammation in mice

mercredi 13 octobre 2021 par Benjamin Thompson, Shamini Bundell
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02806-xThe neurons behind acupuncture’s effect on inflammation, and how antibiotics affect gut bacteria.

Burnt seeds show people used tobacco 12,000 years ago

mercredi 13 octobre 2021 par Tosin Thompson
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02789-9The earliest evidence that Stone Age hunter-gatherers chewed or smoked the plant have been discovered among the remains of an ancient fire.

Opioid peptide signal in the brain makes mice hungrier for reward

mercredi 13 octobre 2021 par Lola Welsch, Brigitte L. Kieffer
Nature, Published online: 13 October 2021; doi:10.1038/d41586-021-02723-zRelease of opioid peptide in the brain leads food-deprived mice to eat more sugar than do mice that are well fed. This opioid signalling mechanism fine-tunes the reward value of food according to the animal’s (...)

Leprosy in wild chimpanzees

mercredi 13 octobre 2021 par Kimberley J. Hockings, Benjamin Mubemba, Charlotte Avanzi, Kamilla Pleh, Ariane Düx, Elena Bersacola, Joana Bessa, Marina Ramon, Sonja Metzger, Livia V. Patrono, Jenny E. Jaffe, Andrej Benjak, Camille Bonneaud, Philippe Busso, Emmanuel Couacy-Hymann, Moussa Gado, Sebastien Gagneux, Roch C. Johnson, Mamoudou Kodio, Joshua Lynton-Jenkins, Irina Morozova, Kerstin Mätz-Rensing, Aissa Regalla, Abílio R. Said, Verena J. Schuenemann, Samba O. Sow, John S. Spencer, Markus Ulrich, Hyacinthe Zoubi, Stewart T. Cole, Roman M. Wittig, Sebastien Calvignac-Spencer, Fabian H. Leendertz
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03968-4Monitoring of western chimpanzee populations in Guinea-Bissau and Côte d’Ivoire reveals the presence of rare and different genotypes of Mycobacterium leprae, suggesting greater circulation in wild animals than previously (...)

A bimodal burst energy distribution of a repeating fast radio burst source

mercredi 13 octobre 2021 par D. Li, P. Wang, W. W. Zhu, B. Zhang, X. X. Zhang, R. Duan, Y. K. Zhang, Y. Feng, N. Y. Tang, S. Chatterjee, J. M. Cordes, M. Cruces, S. Dai, V. Gajjar, G. Hobbs, C. Jin, M. Kramer, D. R. Lorimer, C. C. Miao, C. H. Niu, J. R. Niu, Z. C. Pan, L. Qian, L. Spitler, D. Werthimer, G. Q. Zhang, F. Y. Wang, X. Y. Xie, Y. L. Yue, L. Zhang, Q. J. Zhi, Y. Zhu
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03878-5For FRB 121102, 1,652 burst events are detected over 47 days, with a peak burst rate of 122 per hour, a bimodal burst rate energy distribution, and no periodicity or (...)

A Jovian analogue orbiting a white dwarf star

mercredi 13 octobre 2021 par J. W. Blackman, J. P. Beaulieu, D. P. Bennett, C. Danielski, C. Alard, A. A. Cole, A. Vandorou, C. Ranc, S. K. Terry, A. Bhattacharya, I. Bond, E. Bachelet, D. Veras, N. Koshimoto, V. Batista, J. B. Marquette
Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03869-6The authors show not only that planetary bodies around white dwarfs can survive but also that more than half of white dwarfs might have Jovian planetary (...)

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