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Research round-up: Cystic fibrosis

mercredi 29 juillet 2020 par Liam Drew
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02115-9Molecular pathways of inflammation, the cystic fibrosis microbiome and other highlights from clinical trials and laboratory studies.

Dinosaur retraction, Neanderthal pain and EU budget woe

mercredi 29 juillet 2020
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02204-9The latest science news, in brief.

The gender gap in cystic fibrosis

mercredi 29 juillet 2020 par Natalie Healey
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02110-0Despite advances in therapies for people with the genetic disease, women seem to have poorer outcomes.

Occupancy maps of 208 chromatin-associated proteins in one human cell type

mercredi 29 juillet 2020 par E. Christopher Partridge, Surya B. Chhetri, Jeremy W. Prokop, Ryne C. Ramaker, Camden S. Jansen, Say-Tar Goh, Mark Mackiewicz, Kimberly M. Newberry, Laurel A. Brandsmeier, Sarah K. Meadows, C. Luke Messer, Andrew A. Hardigan, Candice J. Coppola, Emma C. Dean, Shan Jiang, Daniel Savic, Ali Mortazavi, Barbara J. Wold, Richard M. Myers, Eric M. Mendenhall
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2023-4ChIP–seq and CETCh–seq data are used to analyse binding maps for 208 transcription factors and other chromatin-associated proteins in a single human cell type, providing a comprehensive catalogue of the transcription factor (...)

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

mercredi 29 juillet 2020 par Eliran Kadosh, Irit Snir-Alkalay, Avanthika Venkatachalam, Shahaf May, Audrey Lasry, Ela Elyada, Adar Zinger, Maya Shaham, Gitit Vaalani, Marco Mernberger, Thorsten Stiewe, Eli Pikarsky, Moshe Oren, Yinon Ben-Neriah
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2541-0In two mouse models of intestinal cancer, mutant p53 has an oncogenic effect in the distal gut but a tumour-suppressive effect in the proximal gut, and these opposing properties are determined by the gut (...)

Cystic fibrosis

mercredi 29 juillet 2020 par Herb Brody
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02105-xInnovative therapies are bringing hope to people with this inherited lung disorder.

Mechanisms of stretch-mediated skin expansion at single-cell resolution

mercredi 29 juillet 2020 par Mariaceleste Aragona, Alejandro Sifrim, Milan Malfait, Yura Song, Jens Van Herck, Sophie Dekoninck, Souhir Gargouri, Gaëlle Lapouge, Benjamin Swedlund, Christine Dubois, Pieter Baatsen, Katlijn Vints, Seungmin Han, Fadel Tissir, Thierry Voet, Benjamin D. Simons, Cédric Blanpain
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2555-7Single-cell analysis in a mouse model of skin stretching shows that stretching causes a transient expansion bias in a population of epidermal stem cells, which is associated with chromatin remodelling and changes in (...)

New class of molecule targets proteins outside cells for degradation

mercredi 29 juillet 2020 par Claire Whitworth, Alessio Ciulli
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02211-wMolecules have previously been made that induce protein destruction inside cells. A new class of molecule now induces the degradation of membrane and extracellular proteins — opening up avenues for drug (...)

The coronavirus pandemic has forced rapid changes in care protocols for cystic fibrosis

mercredi 29 juillet 2020 par Jane Davies
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02112-yLockdowns have accelerated the drive towards telemedicine for people with cystic fibrosis — but the system needs critical appraisal.

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

mercredi 29 juillet 2020 par Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu, Xiawei Wei
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2599-8A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

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