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New China virus: Five questions scientists are asking

mercredi 22 janvier 2020 par Ewen Callaway, David Cyranoski
Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00166-6Researchers are racing to find out more about the epidemiology and genetic sequence of the coronavirus spreading in Asia and beyond.

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

mercredi 22 janvier 2020 par Julia Bergild McBrien, Maud Mavigner, Lavinia Franchitti, S. Abigail Smith, Erick White, Gregory K. Tharp, Hasse Walum, Kathleen Busman-Suhay, Christian R. Aguilera-Sandoval, William O. Thayer, Rae Ann Spagnuolo, Martina Kovarova, Angela Wahl, Barbara Cervasi, David M. Margolis, Thomas H. Vanderford, Diane G. Carnathan, Mirko Paiardini, Jeffrey D. Lifson, John H. Lee, Jeffrey T. Safrit, Steven E. Bosinger, Jacob D. Estes, Cynthia A. Derdeyn, J. Victor Garcia, Deanna A. Kulpa, Ann Chahroudi, Guido Silvestri
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1946-0The interleukin-15 superagonist N-803, combined with the depletion of CD8+ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV-infected macaques and (...)

Glacial quakes reveal huge chunks falling off Antarctic ice mass

mercredi 22 janvier 2020
Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00163-9Calving events at Thwaites Glacier, which is shedding vast amounts of ice, are detected from up to 1,600 kilometres away.

Targeting of temperate phages drives loss of type I CRISPR–Cas systems

mercredi 22 janvier 2020 par Clare Rollie, Anne Chevallereau, Bridget N. J. Watson, Te-yuan Chyou, Olivier Fradet, Isobel McLeod, Peter C. Fineran, Chris M. Brown, Sylvain Gandon, Edze R. Westra
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1936-2CRISPR–Cas systems cannot eliminate temperate bacteriophages from bacterial populations and—in this context—the systems impose immunopathological costs on the host, creating selective pressures that may explain their patchy (...)

Podcast: How stress can cause grey hair, and the attitude needed to tackle climate change

mercredi 22 janvier 2020
Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00168-4Hear the latest science news, brought to you by Nick Howe and Benjamin Thompson.

Software searches out reproducibility issues in scientific papers

mercredi 22 janvier 2020 par Dalmeet Singh Chawla
Nature, Published online: 22 January 2020; doi:10.1038/d41586-020-00104-6Papers are getting more rigorous, but progress is slower than some researchers would like.

Ancient West African foragers in the context of African population history

mercredi 22 janvier 2020 par Mark Lipson, Isabelle Ribot, Swapan Mallick, Nadin Rohland, Iñigo Olalde, Nicole Adamski, Nasreen Broomandkhoshbacht, Ann Marie Lawson, Saioa López, Jonas Oppenheimer, Kristin Stewardson, Raymond Neba’ane Asombang, Hervé Bocherens, Neil Bradman, Brendan J. Culleton, Els Cornelissen, Isabelle Crevecoeur, Pierre de Maret, Forka Leypey Mathew Fomine, Philippe Lavachery, Christophe Mbida Mindzie, Rosine Orban, Elizabeth Sawchuk, Patrick Semal, Mark G. Thomas, Wim Van Neer, Krishna R. Veeramah, Douglas J. Kennett, Nick Patterson, Garrett Hellenthal, Carles Lalueza-Fox, Scott MacEachern, Mary E. Prendergast, David Reich
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1929-1Genome-wide ancestry profiles of four individuals, dating to 8,000 and 3,000 years before present, from the archaeological site of Shum Laka (Cameroon) shed light on the deep population history of sub-Saharan (...)

Giant virus diversity and host interactions through global metagenomics

mercredi 22 janvier 2020 par Frederik Schulz, Simon Roux, David Paez-Espino, Sean Jungbluth, David Walsh, Vincent J. Denef, Katherine D. McMahon, Konstantinos T. Konstantinidis, Emiley A. Eloe-Fadrosh, Nikos Kyrpides, Tanja Woyke
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1957-xGiant virus diversity and host interactions through global metagenomics

How the stress of fight or flight turns hair white

mercredi 22 janvier 2020 par Shayla A. Clark, Christopher D. Deppmann
Nature, Published online: 22 January 2020; doi:10.1038/d41586-019-03949-8Signalling from the sympathetic nervous system of mice when subjected to stress leads to the depletion of a stem-cell population in their hair follicles. This discovery sheds light on why stress turns hair prematurely (...)

Structure of the transcription coactivator SAGA

mercredi 22 janvier 2020 par Haibo Wang, Christian Dienemann, Alexandra Stützer, Henning Urlaub, Alan C. M. Cheung, Patrick Cramer
Nature, Published online: 22 January 2020; doi:10.1038/s41586-020-1933-5Structural studies on the yeast transcription coactivator complex SAGA (Spt–Ada–Gcn5–acetyltransferase) provide insights into the mechanism of initiation of regulated transcription by this multiprotein complex, which is (...)

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