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Neuronal vulnerability and multilineage diversity in multiple sclerosis

mercredi 17 juillet 2019 par Lucas Schirmer, Dmitry Velmeshev, Staffan Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, John H. Stockley, Adam Young, Maike Steindel, Brian Tung, Nitasha Goyal, Aparna Bhaduri, Simone Mayer, Jan Broder Engler, Omer A. Bayraktar, Robin J. M. Franklin, Maximilian Haeussler, Richard Reynolds, Dorothy P. Schafer, Manuel A. Friese, Lawrence R. Shiow, Arnold R. Kriegstein, David H. Rowitch
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1404-zSingle-cell RNA sequencing was used to construct a map of gene expression in lesions from brains of patients with multiple sclerosis, revealing distinct lineage- and region-specific transcriptomic changes associated with (...)

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

mercredi 17 juillet 2019 par Jaecheol Lee, Vittavat Termglinchan, Sebastian Diecke, Ilanit Itzhaki, Chi Keung Lam, Priyanka Garg, Edward Lau, Matthew Greenhaw, Timon Seeger, Haodi Wu, Joe Z. Zhang, Xingqi Chen, Isaac Perea Gil, Mohamed Ameen, Karim Sallam, June-Wha Rhee, Jared M. Churko, Rinkal Chaudhary, Tony Chour, Paul J. Wang, Michael P. Snyder, Howard Y. Chang, Ioannis Karakikes, Joseph C. Wu
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1406-xA disease model using cardiomyocytes derived from induced pluripotent stem cells of patients with mutated LMNA-related dilated cardiomyopathy reveals that the abnormal activation of the PDGF pathway is associated with the (...)

Visualizing electrostatic gating effects in two-dimensional heterostructures

mercredi 17 juillet 2019 par Paul V. Nguyen, Natalie C. Teutsch, Nathan P. Wilson, Joshua Kahn, Xue Xia, Abigail J. Graham, Viktor Kandyba, Alessio Giampietri, Alexei Barinov, Gabriel C. Constantinescu, Nelson Yeung, Nicholas D. M. Hine, Xiaodong Xu, David H. Cobden, Neil R. Wilson
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1402-1Changes in the electronic states of two-dimensional semiconductor devices resulting from electrical gating can be monitored directly using micrometre-scale angle-resolved photoemission (...)

Estimating and tracking the remaining carbon budget for stringent climate targets

mercredi 17 juillet 2019 par Joeri Rogelj, Piers M. Forster, Elmar Kriegler, Christopher J. Smith, Roland Séférian
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1368-zA method of tracking changes in estimates of the remaining carbon budget over time should help to reconcile differences between these estimates and clarify their usefulness for setting emission reduction (...)

Ebola spread, Turing honour and mosquito-eradication trial

mercredi 17 juillet 2019
Nature, Published online: 17 July 2019; doi:10.1038/d41586-019-02140-3The week in science: 12–18 July 2019.

Signatures of tunable superconductivity in a trilayer graphene moiré superlattice

mercredi 17 juillet 2019 par Guorui Chen, Aaron L. Sharpe, Patrick Gallagher, Ilan T. Rosen, Eli J. Fox, Lili Jiang, Bosai Lyu, Hongyuan Li, Kenji Watanabe, Takashi Taniguchi, Jeil Jung, Zhiwen Shi, David Goldhaber-Gordon, Yuanbo Zhang, Feng Wang
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1393-yBy varying the vertical displacement field in a trilayer graphene and hexagonal boron nitride moiré superlattice, transitions can be observed from the superconducting phase to Mott insulator and metallic (...)

A calmodulin-gated calcium channel links pathogen patterns to plant immunity

mercredi 17 juillet 2019 par Wang Tian, Congcong Hou, Zhijie Ren, Chao Wang, Fugeng Zhao, Douglas Dahlbeck, Songping Hu, Liying Zhang, Qi Niu, Legong Li, Brian J. Staskawicz, Sheng Luan
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1413-yThe cyclic nucleotide-gated channel proteins CNGC2 and CNGC4 form a calcium channel in Arabidopsis; this channel is blocked by calmodulin in the resting state but is phosphorylated and activated upon pathogen attack, (...)

Thermal conductance of single-molecule junctions

mercredi 17 juillet 2019 par Longji Cui, Sunghoon Hur, Zico Alaia Akbar, Jan C. Klöckner, Wonho Jeong, Fabian Pauly, Sung-Yeon Jang, Pramod Reddy, Edgar Meyhofer
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1420-zThermal conductance of single-molecule junctions

Correcting datasets leads to more homogeneous early-twentieth-century sea surface warming

mercredi 17 juillet 2019 par Duo Chan, Elizabeth C. Kent, David I. Berry, Peter Huybers
Nature, Published online: 17 July 2019; doi:10.1038/s41586-019-1349-2Correction of oddities in the historical record of sea surface temperatures reveals that some basin-wide climate variations were an artefact of systematic biases that stem, in part, from Japanese records being truncated to (...)

Corrections to ocean-temperature record resolve puzzling regional differences

mercredi 17 juillet 2019 par Zeke Hausfather
Nature, Published online: 17 July 2019; doi:10.1038/d41586-019-02147-wAn analysis of the record of sea surface temperature reveals that some climate variations that are thought to have occurred in the North Atlantic and the North Pacific oceans are an artefact of changes in measurement (...)

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