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Pluripotency and the origin of animal multicellularity

mercredi 12 juin 2019 par Shunsuke Sogabe, William L. Hatleberg, Kevin M. Kocot, Tahsha E. Say, Daniel Stoupin, Kathrein E. Roper, Selene L. Fernandez-Valverde, Sandie M. Degnan, Bernard M. Degnan
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1290-4Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells (...)

Hydraulic control of mammalian embryo size and cell fate

mercredi 12 juin 2019 par Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor Mönke, Ryan J. Petrie, Martin Bergert, Alba Diz-Muñoz, L. Mahadevan, Takashi Hiiragi
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1309-xA mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their (...)

Migrant memory B cells secrete luminal antibody in the vagina

mercredi 12 juin 2019 par Ji Eun Oh, Norifumi Iijima, Eric Song, Peiwen Lu, Jonathan Klein, Ruoyi Jiang, Steven H. Kleinstein, Akiko Iwasaki
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1285-1In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary (...)

A licence to kill during inflammation

mercredi 12 juin 2019 par Kengo Nozaki, Edward A. Miao
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01764-9Inflammasomes are protein complexes that fight infection by driving inflammation or cell death. It now seems that the protein NEK7 provides a ‘licence’ for the formation of inflammasomes containing the protein (...)

How 11 experts spent 2 days trying to find consensus on climate and conflict

mercredi 12 juin 2019
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01830-2Expert elicitation draws on diverse specialists to synthesize conflicting views and evidence.

Daily briefing: An X-ray map of the Universe

mercredi 12 juin 2019 par Flora Graham
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01875-3Space telescope marks a “return to world-class science” for Russia, mouse lemurs might be the next big thing in genetics and an open-access publishing model in which journals compete for (...)

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis

mercredi 12 juin 2019 par Ting Su, Toshiaki Izawa, Matthias Thoms, Yui Yamashita, Jingdong Cheng, Otto Berninghausen, F. Ulrich Hartl, Toshifumi Inada, Walter Neupert, Roland Beckmann
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1307-zCryo-electron microscopy structures of the yeast 60S ribosomal subunit in complex with Vms1 provides insights into the roles of proteins in the ribosome-associated quality control (...)

Ozone mystery laid to rest

mercredi 12 juin 2019 par Mathew Evans
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01752-zMeasurements of atmospheric ozone levels taken during the nineteenth century cast doubt on the computational models used today to simulate the atmosphere. An independent proxy of past ozone levels offers (...)

Atypical behaviour and connectivity in SHANK3-mutant macaques

mercredi 12 juin 2019 par Yang Zhou, Jitendra Sharma, Qiong Ke, Rogier Landman, Jingli Yuan, Hong Chen, David S. Hayden, John W. Fisher III, Minqing Jiang, William Menegas, Tomomi Aida, Ting Yan, Ying Zou, Dongdong Xu, Shivangi Parmar, Julia B. Hyman, Adrian Fanucci-Kiss, Olivia Meisner, Dongqing Wang, Yan Huang, Yaqing Li, Yanyang Bai, Wenjing Ji, Xinqiang Lai, Weiqiang Li, Lihua Huang, Zhonghua Lu, Liping Wang, Sheeba A. Anteraper, Mriganka Sur, Huihui Zhou, Andy Peng Xiang, Robert Desimone, Guoping Feng, Shihua Yang
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1278-0The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid (...)

Atypical behaviour and connectivity in SHANK3-mutant macaques

mercredi 12 juin 2019 par Yang Zhou, Jitendra Sharma, Qiong Ke, Rogier Landman, Jingli Yuan, Hong Chen, David S. Hayden, John W. Fisher III, Minqing Jiang, William Menegas, Tomomi Aida, Ting Yan, Ying Zou, Dongdong Xu, Shivangi Parmar, Julia B. Hyman, Adrian Fanucci-Kiss, Olivia Meisner, Dongqing Wang, Yan Huang, Yaqing Li, Yanyang Bai, Wenjing Ji, Xinqiang Lai, Weiqiang Li, Lihua Huang, Zhonghua Lu, Liping Wang, Sheeba A. Anteraper, Mriganka Sur, Huihui Zhou, Andy Peng Xiang, Robert Desimone, Guoping Feng, Shihua Yang
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1278-0The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid (...)

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