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Japanese spacecraft probes asteroid’s guts for first time

mercredi 10 juillet 2019 par Davide Castelvecchi
Nature, Published online: 10 July 2019; doi:10.1038/d41586-019-02136-zHayabusa2 touched down on Ryugu to collect material from beneath the surface.

Planar perovskite solar cells with long-term stability using ionic liquid additives

mercredi 10 juillet 2019 par Sai Bai, Peimei Da, Cheng Li, Zhiping Wang, Zhongcheng Yuan, Fan Fu, Maciej Kawecki, Xianjie Liu, Nobuya Sakai, Jacob Tse-Wei Wang, Sven Huettner, Stephan Buecheler, Mats Fahlman, Feng Gao, Henry J. Snaith
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1357-2Addition of an ionic liquid, BMIMBF4, to metal halide perovskite solar cells improves their efficiency and long-term operation under accelerated aging conditions of high temperature and full-spectrum (...)

Comprehensive single-cell transcriptome lineages of a proto-vertebrate

mercredi 10 juillet 2019 par Chen Cao, Laurence A. Lemaire, Wei Wang, Peter H. Yoon, Yoolim A. Choi, Lance R. Parsons, John C. Matese, Michael Levine, Kai Chen
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1385-yComprehensive single-cell transcriptomes in the proto-vertebrate Ciona intestinalis identified provisional gene networks for 41 different neural subtypes, providing insights into the swimming circuit of tadpoles and the (...)

A human liver cell atlas reveals heterogeneity and epithelial progenitors

mercredi 10 juillet 2019 par Nadim Aizarani, Antonio Saviano, Sagar, Laurent Mailly, Sarah Durand, Josip S. Herman, Patrick Pessaux, Thomas F. Baumert, Dominic Grün
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1373-2Single-cell RNA sequencing of cells from healthy human liver, hepatocellular carcinoma and chimaeric mouse liver identifies subtypes of liver cells, epithelial progenitors and differences between healthy and diseased (...)

Polar ice chronicles a toxic metal’s surging production

mercredi 10 juillet 2019
Nature, Published online: 10 July 2019; doi:10.1038/d41586-019-02124-3Samples from the Arctic track rising and falling levels of lead over two millennia.

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

mercredi 10 juillet 2019 par Nalle Pentinmikko, Sharif Iqbal, Miyeko Mana, Simon Andersson, Armand B. Cognetta III, Radu M. Suciu, Jatin Roper, Kalle Luopajärvi, Eino Markelin, Swetha Gopalakrishnan, Olli-Pekka Smolander, Santiago Naranjo, Tuure Saarinen, Anne Juuti, Kirsi Pietiläinen, Petri Auvinen, Ari Ristimäki, Nitin Gupta, Tuomas Tammela, Tyler Jacks, David M. Sabatini, Benjamin F. Cravatt, Ömer H. Yilmaz, Pekka Katajisto
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1383-0Ageing-associated decline in intestinal stem cell function is mediated by increased Notum, a protein inhibitor of stemness-maintaining Wnt signalling, which is secreted by Paneth (...)

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

mercredi 10 juillet 2019 par Katja Faelber, Lea Dietrich, Jeffrey K. Noel, Florian Wollweber, Anna-Katharina Pfitzner, Alexander Mühleip, Ricardo Sánchez, Misha Kudryashev, Nicolas Chiaruttini, Hauke Lilie, Jeanette Schlegel, Eva Rosenbaum, Manuel Hessenberger, Claudia Matthaeus, Séverine Kunz, Alexander von der Malsburg, Frank Noé, Aurélien Roux, Martin van der Laan, Werner Kühlbrandt, Oliver Daumke
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1372-3Crystal and electron cryo-tomography structures of Mgm1 from Chaetomium thermophilum reveal that Mgm1 forms bent tetramers, which further assemble into helical filaments on both positively and negatively curved (...)

Tumour lineage shapes BRCA-mediated phenotypes

mercredi 10 juillet 2019 par Philip Jonsson, Chaitanya Bandlamudi, Michael L. Cheng, Preethi Srinivasan, Shweta S. Chavan, Noah D. Friedman, Ezra Y. Rosen, Allison L. Richards, Nancy Bouvier, S. Duygu Selcuklu, Craig M. Bielski, Wassim Abida, Diana Mandelker, Ozge Birsoy, Liying Zhang, Ahmet Zehir, Mark T. A. Donoghue, José Baselga, Kenneth Offit, Howard I. Scher, Eileen M. O’Reilly, Zsofia K. Stadler, Nikolaus Schultz, Nicholas D. Socci, Agnes Viale, Marc Ladanyi, Mark E. Robson, David M. Hyman, Michael F. Berger, David B. Solit, Barry S. Taylor
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1382-1Analysis of more than 17,000 tumours suggests that the contribution of germline and somatic mutations in the BRCA1 and BRCA2 genes to oncogenesis depends on tumour (...)

scSLAM-seq reveals core features of transcription dynamics in single cells

mercredi 10 juillet 2019 par Florian Erhard, Marisa A. P. Baptista, Tobias Krammer, Thomas Hennig, Marius Lange, Panagiota Arampatzi, Christopher S. Jürges, Fabian J. Theis, Antoine-Emmanuel Saliba, Lars Dölken
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1369-yA technique known as scSLAM-seq that combines single-cell RNA sequencing with metabolic RNA labelling and nucleoside conversion is used to study the onset of cytomegalovirus infection in single mouse (...)

Mechanisms of RALF peptide perception by a heterotypic receptor complex

mercredi 10 juillet 2019 par Yu Xiao, Martin Stegmann, Zhifu Han, Thomas A. DeFalco, Katarzyna Parys, Li Xu, Youssef Belkhadir, Cyril Zipfel, Jijie Chai
Nature, Published online: 10 July 2019; doi:10.1038/s41586-019-1409-7Mechanisms of RALF peptide perception by a heterotypic receptor complex

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